期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 103, 期 1, 页码 69-75出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2012.08.001
关键词
Honeybee; Mushroom bodies; Olfactory conditioning; GABA; Glutamate; Picrotoxin
资金
- French Research Council (CNRS)
- University Paul Sabatier
In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning using a single-trial olfactory conditioning paradigm. The GABAergic antagonist picrotoxin (PTX) or the GluCI antagonist L-trans-pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) was injected alone or in combination into the a-lobes of MBs. PTX impaired early long-term olfactory memory when injected before conditioning or before testing. L-trans-PDC alone induced no significant effect on learning and memory but induced a less specific response to the conditioned odor. When injected before PTX, L-trans-PDC was able to modulate PTX effects. These results emphasize the role of MB GABA-gated chloride channels in consolidation processes and strongly support that GluCls are involved in the perception of the conditioned stimulus. (C) 2012 Elsevier Inc. All rights reserved.
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