Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Priscila Vazquez-Leon, Abraham Miranda-Paez, Hugo Sanchez-Castillo, Bruno A. Marichal-Cancino
Summary: KOR stimulation/blockade in D-PAG during alcohol withdrawal may induce anxiety-like behaviors and alter alcohol intake/preference, exerting greater effects on withdrawal animals compared to naive ones.
PHARMACOLOGICAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Priscila Vazquez-Leon, Abraham Miranda-Paez, Hugo Sanchez-Castillo, Bruno A. Marichal-Cancino
Summary: This study investigated the pharmacological effects of kappa-opioid receptor (KOR) stimulation/blockade in the periaqueductal gray matter (PAG) during alcohol withdrawal. The results showed that KOR stimulation increased anxiety-type behaviors and alcohol consumption/preference, while KOR blockade decreased immobility duration and increased exploration without affecting alcohol intake/preference. These findings suggest a possible pharmacologic hyperreactivity of KOR in PAG during alcohol withdrawal.
PHARMACOLOGICAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpen Wang
Summary: This study identified neural pathways involved in controlling depressive-like behaviors and acute withdrawal symptoms after morphine withdrawal. Furthermore, a new DBS treatment protocol was developed to reverse abnormal plasticity and alleviate withdrawal symptoms and depressive-like behaviors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Cell Biology
Leticia Yoshitome Queiroz, Igor Goncalves de Oliveira, Sabrina de Carvalho Cartagenes, Luanna Melo Pereira Fernandes, Savio Monteiro dos Santos, Wallax Augusto Silva Ferreira, Fernando Augusto Rodrigues Mello Junior, Leonardo Oliveira Bittencourt, Edson Bruno Campos Paiva, Rommel Mario Rodriguez Burbano, Edivaldo Herculano Correa de Oliveira, Marta Chagas Monteiro, Rafael Rodrigues Lima, Eneas Andrade Fontes-Junior, Cristiane do Socorro Ferraz Maia
Summary: This study investigates whether behavioral and cognitive changes induced by binge drinking during adolescence persist until mid and late adulthood. The results show that binge drinking in adolescence leads to anxiety, depression, and impaired short-term memory, and these changes continue to exist even after a long period of abstinence.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Neurosciences
Julie Bailly, Florence Allain, Eric Schwartz, Chloe Tirel, Charles Dupuy, Florence Petit, Marco A. Diana, Emmanuel Darcq, Brigitte L. Kieffer
Summary: This study found that the mu opioid receptor in the brain can promote aversive emotional states, and it is controlled by two different neural pathways (Hb-MOR/interpeduncular nucleus and Hb-MOR/dorsal raphe nucleus) that regulate despair and anxiety, respectively. These findings are important for understanding emotional balance and addiction mechanisms.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Beatriz Moreno-Santos, Camila Marchi-Coelho, Willian Costa-Ferreira, Carlos C. Crestani
Summary: This study demonstrates the presence of different angiotensinergic mechanisms within the MeA controlling behavioral responses in the forced swimming test and elevated plus-maze.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Neurosciences
Lihui Du, Liping Xiao, Chenglin Zou, Jinrong Huang
Summary: This study found that vanillin has an anti-anxiety effect in ethanol withdrawal syndrome, improving behavioral changes. In addition, vanillin treatment can normalize neurotransmitter levels and CRF/CRFR1 expression in ethanol withdrawal rats.
FOLIA NEUROPATHOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Diandra Araujo Luz, Sabrina de Carvalho Cartagenes, Cinthia Cristina Sousa de Menezes da Silveira, Bruno Goncalves Pinheiro, Kissila Marvia Matias Machado Ferraro, Luanna de Melo Pereira Fernandes, Eneas Andrade Fontes-Junior, Cristiane do Socorro Ferraz Maia
Summary: This review discusses the cellular and behavioral changes displayed by mercury and ethanol exposure during adolescence, focusing on emotional disorders. Research indicates that concomitant exposure to mercury and ethanol intensifies symptoms of depression, anxiety, and insomnia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Helena Hui Lin Ngui, Audrey Siew Foong Kow, Sally Lai, Chau Ling Tham, Yu-Cheng Ho, Ming Tatt Lee
Summary: Alcohol use is a social norm in many communities, but excessive consumption or abuse can have detrimental effects on health. This review highlights the impact of alcohol on brain structures and its link to mood disorders. It emphasizes the importance of managing this issue and the urgency to address it appropriately.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yan Yan, Bridget Truitt, Junyi Tao, Sean Michael Boyles, Danielle Antoine, William Hulme, Sabita Roy
Summary: The cycle of substance use disorder leading to dependence is a complex process involving multiple neurocircuitries and brain regions. This study focused on the amygdala, a core brain region involved in withdrawal, anxiety, and depressive-like behaviors, to examine the transcriptional changes in different cell types during substance use disorder. Using single-cell RNA sequencing, the researchers classified all cell types in the mouse amygdala and identified distinct gene expression changes in glial cells during dependence compared to naive or withdrawal state. The findings provide unique insights into the biological processes involved in substance use disorder and the alterations in the brain.
Article
Behavioral Sciences
Kairo Alan Albernaz-Mariano, Rimenez Rodrigues Souza, Azair Canto-de-Souza
Summary: This study investigated the one-trial tolerance (OTT) to benzodiazepines in animals exposed to the elevated plus-maze. It found that the mineralocorticoid receptors in the infralimbic subregion of the medial prefrontal cortex play an important role in the establishment of OTT.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Sukanya G. Gakare, Shejin S. Varghese, Paras P. Patni, Samruddhi A. Wagh, Rajesh R. Ugale
Summary: This study investigated the effects of glutamate transporter inhibitor, GluN2B-containing NMDAR antagonist, and intracellular calcium chelator in the lateral habenula on ethanol withdrawal symptoms. The results showed that inhibiting these factors could alleviate negative behaviors induced by ethanol withdrawal and reduce neuronal loss, suggesting a potential therapeutic approach for ethanol withdrawal symptoms.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)