Article
Behavioral Sciences
Joaquim Barbosa Leite Junior, Luiz Gustavo Soares Carvalho Crespo, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J. Carey, Marinete Pinheiro Carrera
Summary: In this study, it was found that the inhibition of dopamine neurons in the VTA by morphine is a significant factor in the rewarding effects of the drug. The use of apomorphine as a pretreatment was shown to reduce dopamine activity and prevent the locomotor hyperactivity induced by morphine. Moreover, apomorphine also inhibited the ERK activation in the VTA and nucleus accumbens, suggesting its involvement in the behavioral sensitization and conditioned effects of morphine.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Lina I. Skora, James J. A. Livermore, Zoltan Dienes, Anil K. Seth, Ryan B. Scott
Summary: The extent to which high-level, complex functions can proceed unconsciously has been a topic of considerable debate. This study focuses on instrumental conditioning and aims to examine the feasibility of instrumental conditioning in the unconscious domain. The results suggest that complex forms of learning may rely on conscious access.
Article
Neurosciences
Jessica Goedhoop, Tara Arbab, Ingo Willuhn
Summary: By comparing two different experimental paradigms, this study reveals that dopamine signals contain both reward-related and action-related information. The action component of dopamine release is characterized by sustained signals, which reflect the motivation for appetitive action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Wenqi Cai, Huan Ma, Yufeng Xun, Wenjuan Hou, Limin Wang, Xueni Zhang, Yufeng Ran, Wei Yuan, Qianqian Guo, Jing Zhang, Laifu Li, Yang Yang, Yitong Li, Zijian Lv, Zhixiong He, Rui Jia, Fadao Tai
Summary: Fathers in mammals with biparental care play a crucial role in the development of offspring's brain and behavior. Paternal behavior in virgin male ICR mice can be initiated by repeated pup exposure via sensitization, and the dopamine system may be involved in this process.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Marta de Oliveira Barreiros, Felipe Gomes Barbosa, Diego de Oliveira Dantas, Daniel de Matos Luna dos Santos, Sidarta Ribeiro, Giselle Cutrim de Oliveira Santos, Allan Kardec Barros
Summary: Studies using zebrafish in neuro-behavioural research are increasing, with computational methods being one of the most efficient ways to measure fish behavior. The automated system allows for conditioning and assessment of zebrafish behavior, providing greater stability in experiments and individual fish analysis.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Herve, Jean-Antoine Girault, Yuki Nakamura
Summary: The study indicates that chemogenetic inhibition of D1-neurons reduces both spontaneous and cocaine-induced locomotor activity, prevents sensitization induction, and blocks sensitized locomotion in a two-injection protocol of sensitization, but does not reverse established sensitization.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Lina Schonfeld, Emily J. Jaehne, Alexandra R. Ogden, Jereme G. Spiers, Samuel Hogarth, Maarten van den Buuse
Summary: Adolescent stress and chronic abuse of methamphetamine have been compared in terms of dopaminergic behavioral sensitization in adulthood. The study found that chronic adolescent treatment with corticosterone reduced meth-induced locomotor hyperactivity in adulthood, while chronic meth treatment in adolescence enhanced meth hyperlocomotion. BDNF does not appear to be involved in these effects of chronic corticosterone or chronic meth.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Jourdyn A. Lawrence, Ichiro Kawachi, Kellee White, Mary T. Bassett, David R. Williams
Summary: This study utilized instrumental variable analysis to examine the relationship between racial discrimination in institutional settings and blood pressure. The findings suggested that increased experiences of racial discrimination were associated with higher blood pressure levels, contributing to cardiovascular health disparities.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Behavioral Sciences
I Nahmoud, J. Ganay Vasquez, H. Cho, T. Dennis-Tiwary, E. Likhtik
Summary: Research indicates that high anxiety animals benefit from salient safety training to improve exploration and discrimination of new non-threatening stimuli.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
I-Mei Liao, Jin-Chung Chen
Summary: The study suggests that the mesolimbic D4 receptor does not play a crucial role in regulating behavioral sensitization induced by hyperdopaminergia, extending to the therapeutic effects of clozapine. Alternative molecular targets should be prioritized for future therapeutics targeting hyperdopaminergia-dependent neuropsychiatric disorders.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Experimental
L. Skora, M. R. Yeomans, H. S. Crombag, R. B. Scott
Summary: The study found that participants were unable to adjust their behavior to approach positive stimuli and avoid negative stimuli through unconscious instrumental conditioning in two experiments. This suggests that consciousness might be necessary for adaptive behavior where selective action is required.
Article
Pharmacology & Pharmacy
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study focused on the time-dependent neurochemical changes induced by amphetamine which revealed region and dose-dependent alterations in gene expression. Individual differences in neurotransmission and gene expression in brain pathways may influence behavioral sensitization to amphetamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Yang Lv, Man-yi Jing, Pei-yun Li, Tai-yun Zhao, Chong Pang, Guan-yi Lu, Zhi-yuan Wang, Ning Wu, Gang Hu, Rui Song, Jin Li
Summary: This study found that Aqp4-knockout mice exhibited attenuated heroin consumption and heroin-seeking behaviors. Additionally, these mice displayed diminished hyperactivity induced by morphine and heroin and subsequently showed dramatically inhibited morphine-induced behavioral sensitization. The attenuated response to opioids was accompanied by a decreased dopamine response in the Nucleus Accumbens and increased dopamine transporters in the striatum.
Article
Agriculture, Dairy & Animal Science
Elia Gatto, Maria Santaca, Ilaria Verza, Marco Dadda, Angelo Bisazza
Summary: Automated training devices are commonly used in warm-blood vertebrates for cognitive function studies, while manual training procedures are standard in fish and lower vertebrates, limiting cross-species comparison. Guppies trained with an automated device showed lower performance compared to traditionally-trained ones. Modifying the automated device did not significantly improve performance, suggesting limitations in small teleosts' ability to handle operant conditioning devices.
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)