Article
Clinical Neurology
Xinhua Yang, Jia Huang, Phillippa Harrision, Matthew E. Roser, Kai Tian, Dongfang Wang, Guangya Liu
Summary: Motivational anhedonia presents differently across psychiatric patients, with acute phase schizophrenia showing the most severe effects, bipolar mania resembling schizophrenia, and bipolar depression resembling unipolar depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Riqiang Yan, Xin-Ming Ma
Summary: The study found that Klotho (KL) is a glycosyl hydrolase and aging-suppressor gene. KL is regulated by estrogen and plays an important role in stress responsiveness, which is highly comorbid with depression and anxiety. The results showed that KL is regulated by estrogen in rat hippocampal neurons and is essential for synapse formation mediated by estrogen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Simone Cunningham, Raegan Mazurka, Katherine E. Wynne-Edwards, Roumen Milev, Diego A. Pizzagalli, Sidney Kennedy, Kate L. Harkness
Summary: The study found that in men, response to rewards is more positively associated with response to acute stress, and among individuals with depression, the response to rewards is more closely related to stress reactivity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Food Science & Technology
Nikoline Bach Hyldelund, Derek Victor Byrne, Raymond C. K. Chan, Barbara Vad Andersen
Summary: This research study explored the relationship between anhedonia, mental disorders, and pleasure from food. The findings showed that individuals with different levels of anhedonia have different perceptions of food pleasure.
Review
Psychology, Clinical
Xuan Wang, Yinghao Zhang, Jia Huang, Yi Wang, Yanzhe Niu, Simon S. Y. Lui, Li Hui, Raymond C. K. Chan
Summary: This systematic review and meta-analysis examined the brain dysfunction related to reward processing in individuals with schizophrenia spectrum disorders and risks. The results showed reduced functional activation across the spectrum, involving the striatum, orbital frontal cortex, cingulate cortex, and cerebellar areas.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Sugai Liang, Yue Wu, Li Hanxiaoran, Andrew J. Greenshaw, Tao Li
Summary: Anhedonia, a prominent symptom in psychiatric disorders such as major depressive disorder (MDD) and schizophrenia, is associated with deficits in neural reward and aversion functions. In MDD, anhedonia is characterized by impairments in anticipatory pleasure and integration of reward-related information, while in schizophrenia it is associated with neurocognitive deficits in representing the value of rewards. Dysregulation of frontostriatal, mesocortical, and mesolimbic circuits may underlie reward and aversion impairments in anhedonia. Dysfunction of the habenula, insula, amygdala, and anterior cingulate cortex contribute to blunted aversion processing in depression and relatively strong aversion in schizophrenia. Patients with schizophrenia show greater abnormal activation and extended functional coupling compared to those with depression. Understanding the neural mechanisms underlying anhedonia in psychiatric disorders can aid in developing targeted and efficacious treatment strategies.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Behavioral Sciences
Diana Fonseca-Rodrigues, Joana Goncalves, Ines Laranjeira, Armando Almeida, Filipa Pinto-Ribeiro
Summary: This study compared six commonly used sucrose preference test (SPT) protocols in male and female Wistar Han rats and found that water/food deprivation did not significantly affect sucrose intake and preference, increasing the duration of the test was associated with increased sucrose preference, and there were no sex-specific differences in the basal sucrose preference of Wistar Han rats. The results suggest the need for protocol standardization and recommend a protocol without food/water deprivation and a 12-hour duration for measuring anhedonia in rodents.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Lauren T. Catalano, Jonathan K. Wynn, Michael F. Green, James M. Gold
Summary: Diminished social motivation is a core feature of schizophrenia that may be associated with disturbances in social reward processing. This study found that individuals with schizophrenia showed reduced anticipation of social rewards compared to nonsocial rewards. However, both schizophrenia participants and healthy participants exhibited similar responses to social and nonsocial rewards. In addition, the anticipation of social rewards during a task was associated with more social approach behaviors in individuals with schizophrenia. These findings suggest intact social reward liking and impaired wanting in schizophrenia.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Roselinde H. Kaiser, Amelia D. Moser, Chiara Neilson, Elena C. Peterson, Jenna Jones, Christina M. Hough, Benjamin M. Rosenberg, Christina F. Sandman, Christopher D. Schneck, David J. Miklowitz, Naomi P. Friedman
Summary: Adolescence is a crucial period for both neurocognitive development and the increased prevalence of mood disorders. This cross-sectional study replicated the developmental patterns of neurocognition and examined whether mood symptoms influenced these developmental effects. The findings suggest that neurocognitive development is altered in adolescents with mood pathology and provide directions for future longitudinal studies.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Chloe C. Boyle, Julienne E. Bower, Naomi I. Eisenberger, Michael R. Irwin
Summary: Anhedonia, a common feature of depression, is characterized by impaired pleasurable response to reward, reduced reward motivation, and/or deficits in reward-related learning. Stress-induced inflammation may be a plausible mechanism for these reward deficits. This paper reviews evidence for the effects of stress and inflammation on reward function and highlights the need for further scientific inquiry to inform the development of precise interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Psychiatry
Angela Pisoni, Simon W. Davis, Moria Smoski
Summary: Anhedonia, the loss of pleasure or motivation, is a transdiagnostic symptom with implications for mental health. Research suggests increased anhedonia is associated with hyperactivity of the Salience Network in resting and negative stimuli contexts, and a lack of global engagement in positive stimuli contexts. Targeted treatments within the Triple Network Model of Psychopathology and future research directions are discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Danielle A. Swales, Serena Lozza-Fiacco, Elizabeth Helen Andersen, Jessica A. Cooper, Michael T. Treadway, Kai Xia, Crystal Edler Schiller, Susan S. Girdler, Gabriel S. Dichter
Summary: Perimenopausal women who are more sensitive to fluctuations in estradiol levels and have experienced recent life stress may benefit more from transdermal estradiol (TE2) treatment, as evidenced by an increase in reward seeking behaviors.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Neurosciences
Sophia C. Levis, Stephen V. Mahler, Tallie Z. Baram
Summary: Opioid use disorder (OUD) is not typically a singular psychiatric condition, with comorbid symptoms likely tied to various risk factors. Early life adversity may disrupt reward circuit development, potentially contributing to OUD and other comorbid neuropsychiatric disorders.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)