期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 90, 期 3, 页码 325-330出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.03.010
关键词
Parkinson's disease; histamine; receptor; turning behavior; rat
The role of histamine and its receptors in basal ganglia neurocircuitry was assessed in apomorphine-induced turning behavior. Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta and medial forebrain bundle were administered histaminergic agents, and apomorphine-induced turning behavior was tested on Days 7 and 14 post-lesion. Compared with saline-treated rats, histidine (500 mg/kg, i.p.), a precursor of histamine, increased turning behavior (p<0.05), while a-fluoromethylhistidine (alpha-FMH, 25 mu g, i.c.v.), an irreversible inhibitor of histidine decarboxylase, decreased turning behavior (p<0.05) but only on Day 14 post-lesion. Both the histamine H-1 receptor antagonist pyrilamine (10 and 50 mu g, i.c.v.) and the H-2 receptor antagonist cimetidine (10 and 50 mu g, i.c.v.) significantly decreased turning behavior on Days 7 and 14 post-lesion. The histamine H-3 receptor agonist immepip (10 mu g, i.c.v.) decreased turning behavior (p<0.05) on Day 14 post-lesion. The present findings indicate the complex interactions of histamine on basal ganglia function. (C) 2008 Elsevier Inc. All rights reserved.
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