Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Sema Oral, Gokhan Goktalay
Summary: By disrupting prepulse inhibition (PPI) modeling of schizophrenia, rats can be divided into different groups based on baseline PPI values, showing varying responses to pharmacological agents. Amphetamine disrupted PPI in both low and high inhibitory groups, while other agents only affected PPI levels in the high inhibitory group.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Nikolaos Pitsikas, Elli Zoupa, Achille Gravanis
Summary: The study demonstrated that BNN27 could alleviate non-spatial, spatial recognition, and discrete memory deficits induced by apomorphine in rats, independent of changes in locomotor activity. This suggests that BNN27 is effective in counteracting cognitive impairments caused by the D1/D2 receptor agonist, highlighting a functional interaction between BNN27 and the DAergic system that may be relevant for schizophrenia-like behavioral symptoms.
PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Hannah F. Waguespack, Rafael S. Maior, Carolina Campos-Rodriguez, Jessica T. Jacobs, Ludise Malkova, Patrick A. Forcelli
Summary: Sensorimotor gating is disrupted in neuropsychiatric disorders, and prepulse inhibition (PPI) is a form of sensorimotor gating that has been widely studied in rodents. However, recent research shows differences in the circuitry controlling PPI between rodents and macaques. While the nucleus accumbens is a key modulatory node for PPI in rodents, its role in primates has yet to be investigated. In this study, we found that quinpirole disrupts PPI in macaques when infused into the nucleus accumbens, unlike muscimol which had no effect.
Article
Psychiatry
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Eunjoon Kim
Summary: The lack of IRSp53 results in decreased PPI, and the hyperactive ACC-MDT pathway suppresses PPI.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mariana Acquarone, A. Poleto, A. F. Perozzo, P. F. R. Goncalves, R. Panizzutti, J. R. L. Menezes, G. A. Neves, Helene Santos Barbosa
Summary: Chronic infection with Toxoplasma gondii may induce behavioral changes associated with neuropsychiatric disorders and dysfunction in glutamatergic neurotransmission, but behavioral and cognitive aspects remain maintained in infected mice despite severe neural damage.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa
Summary: The study reanalyzed previously identified quantitative trait loci for prepulse inhibition (PPI) and identified a PPI-regulating Cdh23 variant, as well as a possible contribution of CDH23 to schizophrenia susceptibility.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychology, Multidisciplinary
Ole Asli, Marta F. Johansen, Ida Solhaug
Summary: Mindfulness practice was found to increase prepulse facilitation in the study, using a prepulse inhibition/facilitation paradigm to investigate the effect on automatic attention regulation processes. The brief mindfulness exercise was shown to have an impact on startle response modulation, specifically increasing preparation for upcoming stimuli.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
K. T. Sun, Jimmy W. Y. Lam, William C. S. Tai, Benson W. M. Lau, Benjamin K. Yee
Summary: The study found that in mouse experiments, trials showing a stronger prepulse response also exhibited a larger startle response to the subsequent pulse stimulus, indicating weaker PPI. Within-subjects and between-subjects analyses revealed contrasting relationships between the direct motor response to the prepulse and the inhibition of subsequent startle reaction induced by the same prepulse.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Plant Sciences
Noah A. Omeiza, Adewale G. Bakre, Halimat A. Abdulrahim, Happy Isibor, Precious U. Ezurike, Abimbola A. Sowunmi, Benneth Ben-Azu, Adegbuyi O. Aderibigbe
Summary: The study demonstrates the antipsychotic activity of Carpolobia lutea decoction in mice models of psychosis, preventing symptoms associated with schizophrenia. The most effective dose was found to be 800 mg/kg.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Psychiatry
Qijing Bo, Zhen Mao, Qing Tian, Ningbo Yang, Xianbin Li, Fang Dong, Fuchun Zhou, Liang Li, Chuanyue Wang
Summary: The study revealed that PSSPPI may serve as a promising objective approach to identify CHR individuals, who demonstrated lower PPI levels compared to healthy controls.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Behavioral Sciences
Heath W. Shelton, S. Prasad Gabbita, W. Drew Gill, Katherine C. Burgess, Wyatt S. Whicker, Russell W. Brown
Summary: The study evaluated a new immune modulator PD2024 targeting TNF-α to alleviate sensorimotor gating deficits and microglial activation in two different rodent models of schizophrenia. The results suggest that targeting brain TNF-α may be a viable pharmacological approach to treat neuroinflammation associated with schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
A. R. Deane, N. Potemkin, R. D. Ward
Summary: This study used the maternal immune activation rat model to investigate the role of MAPK in sensorimotor gating and adaptive learning deficits in schizophrenia. The findings showed a negative correlation between MAPK expression and PPI exclusively in MIA rats, suggesting a modulatory role for MAPK in sensorimotor gating pathology. Additionally, the correlation between MAPK and adaptive learning capacity observed in control rats was absent in rats exposed to MIA.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Isis Gil-Miravet, Alejandro Fuertes-Saiz, Ana Benito, Isabel Almodovar, Enrique Ochoa, Gonzalo Haro
Summary: This study evaluated the PPI and phenotype of patients with CRD and psychiatric disorders, finding differences in PPI between groups but overall indicating PPI as a non-specific endophenotype in certain mental disorders.
Article
Behavioral Sciences
Nurith Amitai, Susan Powell, Martin Weber, Neal R. Swerdlow, Jared W. Young
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2015)
Article
Neurosciences
Shih-Ching Lo, Yuanyuan Wang, Martin Weber, Jessica L. Larson, Kimberly Scearce-Levie, Morgan Sheng
JOURNAL OF NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Martin Weber, Tiffany Wu, William J. Meilandt, Sara L. Dominguez, Hilda O. Solanoy, Janice A. Maloney, Hai Ngu, Miriam Baca, Chung Kung, Lisa Lima, Timothy K. Earr, Daniel Fleck, Shannon D. Shields, William F. Forrest, Oded Foreman, Soren Warming, Ryan J. Watts, Kimberly Scearce-Levie
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Sara L. Dominguez, Ganapati V. Hegde, Jesse E. Hanson, Hong Xiang, Danielle Mandikian, C. Andrew Boswell, Cecilia Chiu, Yan Wu, Siao Ping Tsai, Daniel Fleck, Martin Weber, Hai Ngu, Kimberly Scearce-Levie, Erica L. Jackson
SCIENTIFIC REPORTS
(2018)
Article
Behavioral Sciences
Wei-li Chang, Mark A. Geyer, Mahalah R. Buell, Martin Weber, Neal R. Swerdlow
BEHAVIOURAL PHARMACOLOGY
(2010)
Article
Neurosciences
Wei-li Chang, Martin Weber, Michelle R. Breier, Richard L. Saint Marie, Samantha R. Hines, Neal R. Swerdlow
Article
Clinical Neurology
Martin Weber, Wei-Li Chang, Michelle R. Breier, Alex Yang, Mark J. Millan, Neal R. Swerdlow
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2010)
Article
Neurosciences
Jesse E. Hanson, Martin Weber, William J. Meilandt, Tiffany Wu, Tom Luu, Lunbin Deng, Mehrdad Shamloo, Morgan Sheng, Kimberly Scearce-Levie, Qiang Zhou
NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
R. L. Saint Marie, E. J. Miller, M. R. Breier, M. Weber, N. R. Swerdlow
Review
Behavioral Sciences
Nurith Amitai, Martin Weber, Neal R. Swerdlow, Richard F. Sharp, Michelle R. Breier, Adam L. Halberstadt, Jared W. Young
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2013)
Article
Behavioral Sciences
Neal R. Swerdlow, Samantha R. Hines, Sebastian D. Herrera, Martin Weber, Michelle R. Breier
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2013)
Article
Neurosciences
William J. Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Karpagam Srinivasan, Jose Imperio, Tiffany Wu, Martin Weber, Agatha J. Kruse, Kimberly L. Stark, Pamela Chan, Mandy Kwong, Zora Modrusan, Brad A. Friedman, Justin Elstrott, Oded Foreman, Amy Easton, Morgan Sheng, David Hansen
JOURNAL OF NEUROSCIENCE
(2020)
Article
Cell Biology
Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S. Khan, Jeffrey Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, T. Michael Gill, Kimberly Scearce-Levie, Jorge J. Palop
Article
Biochemistry & Molecular Biology
Alexandra M. Whiteley, Miguel A. Prado, Stefanie A. H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley
Summary: This study provides an unbiased and global analysis of Ubqln2's role in controlling the proteome composition, showing impacts on various physiological pathways and identifying specific proteins linked to UBQLN2 function. The research also reveals candidate client proteins whose degradation is promoted by UBQLN2 in disease models.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Martin Weber, Tiffany Wu, Jesse E. Hanson, Nazia M. Alam, Hilda Solanoy, Hai Ngu, Benjamin E. Lauffer, Han H. Lin, Sara L. Dominguez, Jens Reeder, Jennifer Tom, Pascal Steiner, Oded Foreman, Glen T. Prusky, Kimberly Scearce-Levie
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)