Article
Multidisciplinary Sciences
E. S. Grigoryeva, L. A. Tashireva, V. V. Alifanov, O. E. Savelieva, S. V. Vtorushin, M. V. Zavyalova, O. D. Bragina, E. Y. Garbukov, N. V. Cherdyntseva, E. L. Choinzonov, V. M. Perelmuter
Summary: Molecular subtype conversion in circulating tumor cells could be a promising tool for optimizing antitumor therapy in breast cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Danian Dai, Hongmei Wu, Hongkai Zhuang, Rong Chen, Cheng Long, Bo Chen
Summary: This study investigated the clinical and genetic characteristics of ER + / PR- breast cancer patients in China. Different PR statuses indicated diverse biological processes of ER + breast cancer and survival outcomes. Tailored treatment strategies may be needed for ER + / PR- patients.
Article
Health Care Sciences & Services
Mengwei Zhang, Min Yan, Huimin Lv, Limin Niu, Huiai Zeng
Summary: The study found that ER+/PR+ advanced breast cancer patients have better prognosis than ER+/PR- patients undergoing first-line endocrine therapy. Additionally, PR status is an independent predictor of treatment response in hormone receptor-positive HER2 negative patients.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Oncology
Francoise Beltjens, Damien Molly, Aurelie Bertaut, Corentin Richard, Isabelle Desmoulins, Catherine Loustalot, Celine Charon-Barra, Emilie Courcet, Anthony Bergeron, Sylvain Ladoire, Clementine Jankowski, Romain Boidot, Laurent Arnould
Summary: The study confirmed that ER-/PR+ breast cancers are an extremely rare but real subtype, morphologically and histologically similar to triple-negative tumors, with more aggressive phenotypes and differing responses to therapies and clinical outcomes. The likely involvement of SUZ12 in their biology offers potential for the development of new therapeutic alternatives.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Endocrinology & Metabolism
Sailaja Kamaraju, Amy M. Fowler, Elizabeth Weil, Kari B. Wisinski, Thu H. Truong, Martin Lehr, Lubna N. Chaudhary, Yee Chung Cheng, Christopher R. Chitambar, Hallgeir Rui, Douglas Yee, Carol Lange
Summary: Although metastatic breast cancer (MBC) is incurable, the prognosis has significantly improved with the approvals of multiple targeted and cytotoxic therapies. Current approved treatment options for hormone receptor-positive MBC include various endocrine therapies, CDK 4/6 inhibitors, mTOR inhibitors, and PI3 kinase inhibitors. Antiprogestins have shown potential in the treatment of MBC, particularly in patients developing endocrine resistance.
Article
Biotechnology & Applied Microbiology
Stuti Roy, Suryendu Saha, Debanil Dhar, Puja Chakraborty, Kumar Singha Roy, Chitranjan Mukherjee, Arnab Gupta, Samir Bhattacharyya, Anup Roy, Sanghamitra Sengupta, Susanta Roychoudhury, Somsubhra Nath
Summary: This study reveals the role of CUEDC2 in breast cancer, especially in endocrine resistance and mitotic progression. Upregulation of CUEDC2 renders ERα+ve tumors behave similarly to HR-ve tumors with an increase in aneuploidy. Furthermore, CUEDC2 is identified as a potential prognostic marker and therapeutic target in breast cancer management.
CANCER GENE THERAPY
(2022)
Article
Health Care Sciences & Services
Taobo Hu, Yan Chen, Yiqiang Liu, Danhua Zhang, Jiankang Pan, Mengping Long
Summary: The loss of PR expression in ER+/HER2- breast cancers indicates a worse prognosis and insensitivity to anti-estrogen therapy. Various PR expression statuses in these cancers can be indicative of molecular variation, particularly in relation to the activation of growth factor pathways.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Multidisciplinary Sciences
Miguel Tavares Pereira, Ali Kazemian, Hubert Rehrauer, Mariusz P. Kowalewski
Summary: This study investigates the transcriptome profile of canine uterine stromal cells during decidualization and examines the effects of antigestagens on decidualized cells. It reveals the importance of progesterone/progesterone receptor signaling for decidual cell function and identifies differentially expressed genes associated with decreased cell proliferation, adhesion, and vascular and immune modulation in the canine placenta.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Rosemary J. Huggins, Geoffrey L. Greene
Summary: The constitutively active ESR1 Y537S mutation is associated with increased physical interaction of ER alpha and PR, altered gene expression, and potential therapeutic targeting of IRS1 for restoring treatment sensitivity in breast cancers harboring ER alpha Y537S mutations.
Article
Biology
Alejandro La Greca, Nicolas Bellora, Francois Le Dily, Rodrigo Jara, Ana Silvina Nacht, Javier Quilez Oliete, Jose Luis Villanueva, Enrique Vidal, Gabriela Merino, Cristobal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo Vicent, Elmer Fernandez, Miguel Beato, Patricia Saragueta
Summary: Estrogen and progesterone play important roles in the development and transcriptional regulation of endometrial cancer. PAX2 is involved in fine-tuning the interplay between ERalpha and PR in transcriptional regulation, and the open chromatin state of specific regions is associated with regulated genes.
Article
Biochemistry & Molecular Biology
Roser Zaurin, Roberto Ferrari, Ana Silvina Nacht, Jose Carbonell, Francois Le Dily, Jofre Font-Mateu, Lara Isabel de Llobet Cucalon, Enrique Vidal, Antonios Lioutas, Miguel Beato, Guillermo P. Vicent
Summary: In T47D breast cancer cells, 50 pM progestin can activate cell cycle entry and the progesterone gene expression program. Highly accessible sites (HAs) are enriched in RAD21 and CTCF, but PR binding is the driving force for the most robust interactions with hormone-regulated genes, indicating their potential usefulness as targets for therapeutic intervention.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Maria Soares, Assuncao N. Correia, Mariana R. Batista, Jorge Correia, Fernando Ferreira
Summary: Benign feline mammary lesions are common in domestic cats, and the expression of estrogen receptors plays an important role in their development.
Review
Oncology
Juberiya M. Azeez, Thachapillil Ramakrishnan Susmi, Viji Remadevi, Vini Ravindran, Anjana Sasikumar Sujatha, Raveendran Nair Sobha Ayswarya, Sreeharshan Sreeja
Summary: Progesterone, an ovarian steroid hormone, plays a crucial role in regulating biological processes in various tissues. Understanding its role in diseases, particularly breast cancer, is a topic of debate due to conflicting evidence. Further research is needed to explore how progesterone affects breast cancer progression and its impact on different molecular pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
H. G. Ahmed, A. B. mohammed el Hag, K. K. Alanazi, H. M. Alkwai, A. M. Ahmed Abdrhman, A. O. Ahmed Hassan, I. A. Mohamed Ginawi, A. M. Elasbali, H. Sherfi
Summary: This study examined the expression of ER, PR, HER2, and E-cadherin tumor markers in Saudi patients with BC. The findings indicate a higher occurrence of triple-negative BC and HER2 positivity among Saudi women, which are associated with poorer treatment response and prognosis. Additionally, the low loss of E-cadherin suggests a lower invasive rate in Saudi BC patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Oncology
Carol A. Lange
Review
Biochemistry & Molecular Biology
Katherine A. Leehy, Thu H. Truong, Laura J. Mauro, Carol A. Lange
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Oncology
Thu H. Truong, Hsiangyu Hu, Nuri A. Temiz, Kyla M. Hagen, Brian J. Girard, Nicholas J. Brady, Kathryn L. Schwertfeger, Carol A. Lange, Julie H. Ostrander
MOLECULAR CANCER RESEARCH
(2018)
Article
Oncology
Tarah M. Regan Anderson, Shihong Ma, Carlos Perez Kerkvliet, Yan Peng, Taylor M. Helle, Raisa I. Krutilina, Ganesh V. Raj, John A. Cidlowski, Julie H. Ostrander, Kathryn L. Schwertfeger, Tiffany N. Seagroves, Carol A. Lange
MOLECULAR CANCER RESEARCH
(2018)
Article
Oncology
Neeraja Sathyamoorthy, Carol A. Lange
Review
Endocrinology & Metabolism
Amy R. Dwyer, Thu H Truong, Julie H. Ostrander, Carol A. Lange
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2020)
Editorial Material
Endocrinology & Metabolism
Carol A. Lange, Stephen R. Hammes
Summary: The Perspective provides advice for junior researchers in the field of endocrinology, emphasizing the importance of passion, integrity, and innovation in scientific research.
Article
Oncology
Lauryn R. Werner, Katelin A. Gibson, Merit L. Goodman, Dominika E. Helm, Katherine R. Walter, Sean M. Holloran, Gloria M. Trinca, Richard C. Hastings, Howard H. Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfredo A. Molinolo, Mary A. Markiewicz, Prabhakar Chalise, Margaret L. Axelrod, Justin M. Balko, Kent W. Hunter, Zachary C. Hartman, Carol A. Lange, Christy R. Hagan
Summary: Clinical studies have linked the use of progestins, synthetic progesterone, to an increased risk of breast cancer. However, the specific role of native progesterone signaling through the progesterone receptor in breast tumor formation remains poorly understood. Research suggests that progesterone can repress certain immune signaling pathways, potentially promoting tumor development in the mammary gland. This study investigated the effects of progesterone on immune cell populations in mouse mammary glands, as well as the impact of progesterone receptor overexpression on tumor formation and immune cell populations. The findings indicate that progesterone treatment and progesterone receptor overexpression are associated with inhibited immune responses, decreased immune cell populations, and an increased risk of mammary gland tumor development in mice.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Endocrinology & Metabolism
Laura J. Mauro, Angela Spartz, Julia R. Austin, Carol A. Lange
Summary: Ovarian cancer is a rare but lethal gynecologic cancer with difficulties in early detection. Progesterone, previously believed to have a protective role, is now being challenged in its singular function. This article integrates historical perspectives, new research findings, and critical interpretations to provide a broader understanding of the role of progesterone and nPR signaling in ovarian cancer.
Article
Oncology
Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves, Carol A. Lange
Summary: Research shows that in triple-negative breast cancer, the PTK6-driven signaling pathway mediates cell migration via RhoA and AhR signaling pathways, and plays a crucial role in lung metastasis.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Amy R. Dwyer, Thu H. Truong, Carlos Perez Kerkvliet, Kiran Paul, Peter Kabos, Carol A. Sartorius, Carol A. Lange
Summary: Phospho-PR-B collaborates with IRS-1 to promote the outgrowth of endocrine-resistant and stem-like breast cancer cells. Activation of p-PR can lead to tamoxifen insensitivity. Targeting the crosstalk between phospho-PR and IRS-1 may block the emergence of endocrine resistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Carlos Perez Kerkvliet, Amy R. Dwyer, Caroline H. Diep, Robert H. Oakley, Christopher Liddle, John A. Cidlowski, Carol A. Lange
BREAST CANCER RESEARCH
(2020)
Article
Endocrinology & Metabolism
Thu H. Truong, Amy R. Dwyer, Caroline H. Diep, Hsiangyu Hu, Kyla M. Hagen, Carol A. Lange
Review
Endocrinology & Metabolism
Thu H. Truong, Carol A. Lange
Article
Oncology
Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad, Matthew Goetz, Judy Boughey, Jann Sarkaria, Liewei Wang, James N. Ingle, Evanthia Galanis, Antonino B. D'Assoro
BREAST CANCER RESEARCH
(2018)