Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Article
Biochemistry & Molecular Biology
Mu Li, Xintong Zhang, Sixiang Chen, Hanhe Liu, Yuan-Wei Zhang
Summary: This study reveals a novel structural characteristic of the neurotransmitter sodium symporter (NSS) family, specifically in TuriSERT, and demonstrates the unique substrate binding site and 1:1 stoichiometry of sodium-substrate binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Rene Zeiss, Bernhard J. Connemann, Carlos Schoenfeldt-Lecuona, Maximilian Gahr
Summary: The study found that the categorization of the type of association between drug and event affects the results of quantitative signal detection. Causality assessment seems to play a major role in signal detection, particularly concerning rare, unknown, or clinically insignificant adverse drug reactions. Antidepressants appear to significantly increase the bleeding risk, even independent of antithrombotic comedication.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Osama Y. Alshogran, Laith N. Al-Eitan, Shoroq M. Altawalbeh, Hatem A. Aman
Summary: This study investigated the genetic association of dopamine D4 receptor and serotonin transporter genes with psychiatric symptom susceptibility among hemodialysis patients. The findings suggest that certain genetic polymorphisms may be linked to anxiety symptoms in this patient population.
Article
Psychiatry
Miriam A. Schiele, Jan Lipovsek, Pascal Schlosser, Michael Soutschek, Gerhard Schratt, Michael Zaudig, Goetz Berberich, Anna Koettgen, Katharina Domschke
Summary: Altered DNA methylation has been observed in several candidate genes in adult patients with OCD. In this study, an epigenome-wide association study was conducted for the first time in a sample of OCD patients of European ancestry, and significant quantitative trait methylation sites (QTMs) and suggestive hits were identified. These findings may provide valuable insights into the pathogenesis of OCD and potentially serve as peripheral epigenetic markers for OCD risk, informing targeted preventive and therapeutic efforts.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Mu Li, Qingyang Chen, Yuan-Wei Zhang
Summary: Conformational changes in the serotonin transporter (SERT) play a critical role in its transport mechanism. This study presents a cell-based method for studying conformational changes in SERT using fluorescent substrates and fluorescence imaging analysis. The results provide insights into the conformational mechanism of SERT and demonstrate the efficacy of the cell-based fluorometric method in studying monoamine transporters and therapeutic agents for psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alyssa M. West, Katherine M. Holleran, Sara R. Jones
Summary: The serotonin and kappa opioid receptor (KOR) systems play important roles in disorders of negative affect. In this study, the researchers investigated the effects of KOR activation and serotonin reuptake inhibition on serotonin transmission in the substantia nigra pars reticulata (SNr). They found that KOR activation reduced serotonin release and uptake, while serotonin reuptake inhibition increased serotonin release and slowed reuptake. The researchers also demonstrated that short-term activation of KOR altered serotonin responses to reuptake inhibition. These findings highlight the complex interactions between KORs and serotonin in regulating negative affect, and suggest that the KOR system may be a promising target for treating disorders such as anxiety and depression alongside traditional antidepressant treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Ghina Harika-Germaneau, Claire Lafay-Chebassier, Nicolas Langbour, Berangere Thirioux, Issa Wassouf, Xavier Noel, Nemat Jaafari, Armand Chatard
Summary: This study shows that the severity of symptoms interacts with the serotonin transporter gene in predicting the frequency of lifetime suicide attempts in patients with psychiatric disorders. Patients carrying the short allele of the gene are more likely to attempt suicide when their symptoms are severe, while no such relationship is found in patients carrying the long allele.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman
Summary: This study re-evaluated one of the most cited and disputed papers in gene-environment interaction literature, using a genome-wide polygenic indicator to examine the genetic determinants of stress sensitivity. The results supported the stress-diathesis perspective and validated the scientific contributions of the original paper.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Darrick K. Li, Shawn Y. Ong, Michelle L. Hughes, Kenneth W. Hung, Ritu Agarwal, Jamil Alexis, John Damianos, Shreyak Sharma, Jacqueline Pires, Michael Nanna, Loren Laine
Summary: Guidelines recommend against aspirin use for primary prevention of cardiovascular events in patients with a history of gastrointestinal bleeding. However, in hospitalized patients, the rate of aspirin discontinuation is low. Processes to ensure appropriate deprescription of aspirin are needed to improve guideline adherence.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Raymond W. Lam, Hee-Kit Wong, Ramruttun A. Kumarsing, Anna N. Chua, Roger C. Ho, Roger S. McIntyre, Cyrus S. Ho
Summary: This study aimed to investigate the effect of fluoxetine on bone microarchitecture and mechanical properties in a rodent model of depression. The results showed that fluoxetine did not significantly affect trabecular number compared to the control group, but had a significant reduction when compared to the group with depression induced by chronic mild stress (CMS). Fluoxetine also significantly increased the cross-sectional area, trabecular bone area, structural strength, and osteoblasts/bone area.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Gastroenterology & Hepatology
Craig C. Reed, Corey J. Ketchem, Talya L. Miller, Evan S. Dellon
Summary: This study aimed to investigate the prevalence of psychiatric diagnoses and medication use in nonesophageal EGID patients and assess their impact on clinical presentation. The results showed that psychiatric diagnoses were common in nonesophageal EGID patients, with approximately 7 in 10 adults and one-third of children diagnosed. Psychiatric illnesses may also influence age at clinical presentation and symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takafumi Hara, Emi Yoshigai, Takuto Ohashi, Toshiyuki Fukada
Summary: Zinc is a crucial trace element with important physiological functions in various cellular processes. It is involved in the immune response, skin health, and cardiovascular functions. Recent studies have highlighted the role of zinc as a signaling molecule in cardiovascular processes, emphasizing the need for a comprehensive understanding of its significance and potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Megan L. Koleske, Gregory McInnes, Julia E. H. Brown, Neil Thomas, Keino Hutchinson, Marcus Y. Chin, Antoine Koehl, Michelle R. Arkin, Avner Schlessinger, Renata C. Gallagher, Yun S. Song, Russ B. Altman, Kathleen M. Giacomini
Summary: This study investigated the impact of variants in the SLC22A5 gene on the function of the carnitine transporter protein OCTN2 and created a predictive model. The results showed that most variants reduced carnitine transport, with some severely impairing function by at least 80%. Additionally, the study identified a major mechanism causing the loss of OCTN2 function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Laura Siles, Sheila Ruiz-Nogales, Arnau Navines-Ferrer, Pilar Mendez-Vendrell, Esther Pomares
Summary: Inherited retinal dystrophies, such as Stargardt disease, lack effective treatment options. However, advances in genome editing technologies like CRISPR-Cas9 and human induced pluripotent stem cells have revolutionized disease modeling and personalized medicine. This study demonstrates precise correction of two pathogenic variants in ABCA4 genes in human induced pluripotent stem cells, providing a new avenue for developing gene and cell therapies for inherited retinal dystrophies.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Neurosciences
Wynne Q. Zhang, Corey M. Smolik, Priscilla A. Barba-Escobedo, Monica Gamez, Jesus J. Sanchez, Martin A. Javors, Lynette C. Daws, Georgianna G. Gould
Article
Neurosciences
Felix P. Mayer, Diethart Schmid, W. Anthony Owens, Georgianna G. Gould, Mia Apuschkin, Oliver Kudlacek, Isabella Salzer, Stefan Boehm, Peter Chiba, Piper H. Williams, Hsiao-Huei Wu, Ulrik Gether, Wouter Koek, Lynette C. Daws, Harald H. Sitte
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Marine & Freshwater Biology
Kristin A. Connors, Theodore W. Valenti, Kelly Lawless, James Sackerman, Emmanuel S. Onaivi, Bryan W. Brooks, Georgianna G. Gould
AQUATIC TOXICOLOGY
(2014)
Article
Engineering, Environmental
Theodore W. Valenti, Georgianna G. Gould, Jason P. Berninger, Kristin A. Connors, N. Bradley Keele, Krista N. Prosser, Bryan W. Brooks
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2012)
Article
Behavioral Sciences
P. A. Barba-Escobedo, G. G. Gould
GENES BRAIN AND BEHAVIOR
(2012)
Article
Biochemistry & Molecular Biology
Georgianna G. Gould, Julie G. Hensler, Teresa F. Burke, Robert H. Benno, Emmanuel S. Onaivi, Lynette C. Daws
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Neurosciences
Rebecca E. Horton, Deana M. Apple, W. Anthony Owens, Nicole L. Baganz, Sonia Cano, Nathan C. Mitchell, Melissa Vitela, Georgianna G. Gould, Wouter Koek, Lynette C. Daws
JOURNAL OF NEUROSCIENCE
(2013)
Review
Pharmacology & Pharmacy
Valentina R. Garbarino, T. Lee Gilman, Lynette C. Daws, Georgianna G. Gould
PHARMACOLOGICAL RESEARCH
(2019)
Article
Clinical Neurology
Georgianna G. Gould, Alexandre Seillier, Gabriela Weiss, Andrea Giuffrida, Teresa F. Burke, Julie G. Hensler, Crystal Rock, Amanda Tristan, Lance R. McMahon, Alexander Salazar, Jason C. O'Connor, Neera Satsangi, Rajiv K. Satsangi, Ting-Ting Gu, Keenan Treat, Corey Smolik, Stephen T. Schultz
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2012)
Article
Endocrinology & Metabolism
Georgianna G. Gould, Teresa F. Burke, Miguel D. Osorio, Corey M. Smolik, Wynne Q. Zhang, Emmanuel S. Onaivi, Ting-Ting Gu, Mauris N. DeSilva, Julie G. Hensler
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Pharmacology & Pharmacy
Nathan C. Mitchell, Georgianna G. Gould, Corey M. Smolik, Wouter Koek, Lynette C. Daws
FRONTIERS IN PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Valentina R. Garbarino, Taylor A. Santos, Anastassia R. Nelson, Wynne Q. Zhang, Corey M. Smolik, Martin A. Javors, Lynette C. Daws, Georgianna G. Gould
PHARMACOLOGICAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Nasriya A. Witt, Benita Lee, Kaylee Ghent, Wynne Q. Zhang, Alan L. Pehrson, Connie Sanchez, Georgianna G. Gould
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
T. Lee Gilman, W. Anthony Owens, Christina M. George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A. Bowman, Georgianna G. Gould, Glenn M. Toney, Lynette C. Daws
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Behavioral Sciences
Kayla R. Nygaard, Raylynn G. Swift, Rebecca M. Glick, Rachael E. Wagner, Susan E. Maloney, Georgianna G. Gould, Joseph D. Dougherty
Summary: Williams Syndrome leads to distinct behavioral phenotypes, such as learning deficits, anxiety, heightened phobias, and hypersociability. While some studies suggest a possible involvement of oxytocin dysregulation, experimental results did not confirm this hypothesis.
GENES BRAIN AND BEHAVIOR
(2022)