期刊
PHARMACOLOGY & THERAPEUTICS
卷 127, 期 3, 页码 271-282出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2010.04.003
关键词
Antidepressant; Glutamate; Serotonin; Sigma receptor; Signal transduction; Neuroplasticity; Neurogenesis
资金
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA011979, R01DA013978] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01 DA011979-01A2, R01 DA011979, R01 DA013978-01A1, R01 DA013978] Funding Source: Medline
Despite the widespread and devastating impact of depression on society, our current understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate, providing relief to only a subset of people suffering from depression. The search for more effective antidepressant drugs includes the investigation of new molecular targets. Among them, current data suggests that sigma receptors are involved in multiple processes effecting antidepressant-like actions in vivo and in vitro. This review summarizes accumulated evidence supporting a role for sigma receptors in antidepressant effects and provides a conceptual framework for delineating their potential roles over the course of antidepressant treatment. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据