Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Xinzou Fan, Panyin Shu, Ying Wang, Ning Ji, Dunfang Zhang
Summary: Neutrophils are the predominant immune cells in human peripheral circulation that play a crucial role in fighting infections, autoimmune diseases, and cancer. This review discusses the physiological roles of Th17 cells and neutrophils, their interactions, and their involvement in pathological processes. The study also provides a summary of drugs targeting IL-17A and their clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Review
Immunology
Hiroyuki Yoshitomi, Hideki Ueno
Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Yao Huang, Xin Ba, Liang Han, Hui Wang, Weiji Lin, Zhe Chen, Shenghao Tu
Summary: The interactions between T cells and B cells play a crucial role in antibody responses and the development of autoimmune diseases. A recent discovery of a distinct subset of T cells called peripheral helper T (Tph) cells in synovial fluid has shed light on their potential roles in autoimmune diseases. Tph cells express high levels of CXCL13, which drive the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately promoting the production of pathogenic autoantibodies. Further investigation of Tph cells may provide valuable insights into the pathogenesis of autoimmune diseases and identify novel therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Immunology
Matheus Braga, Fernanda Formaggi Lara-Armi, Janisleya Silva Ferreira Neves, Marco Antonio Rocha-Loures, Mariana de Souza Terron-Monich, Larissa Danielle Bahls-Pinto, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Ana Maria Sell, Jeane Eliete Laguila Visentainer
Summary: The IL10 -1082 A>G (rs1800896) genotype is associated with AS, with AS patients having higher levels of IL-10 in serum, and the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Cell Biology
Felix Ritzmann, Lars Peter Lunding, Robert Bals, Michael Wegmann, Christoph Beisswenger
Summary: IL-17 cytokines play an important role in chronic lung diseases, contributing to bacterial elimination but also potentially promoting disease progression.
Article
Multidisciplinary Sciences
Steven C. Wilson, Nathanael A. Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M. Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K. Christopher Garcia
Summary: The IL-17 family of cytokines and receptors play crucial roles in host defence and inflammatory diseases. The IL-25-IL-17RB-IL-17RA ternary complex is a C2-symmetric complex, where IL-25 interacts with IL-17RB and two 'wing-like' IL-17RA co-receptors to initiate signal transduction through a 'tip-to-tip' geometry.
Article
Infectious Diseases
Narjes Soleimanifar, Sara Assadiasl, Abdolrahman Rostamian, Alireza Abdollahi, Mohammadreza Salehi, Mohsen Abdolmaleki, Saeed Barzegari, Abolfazl Sobati, Maryam Sadr, Bahareh Mohebbi, Hanieh Mojtahedi, Mohammad Hossein Nicknam
Summary: This study found that the percentage of Th17 cells in COVID-19 patients with mucormycosis was significantly lower than in COVID-19 patients and healthy individuals, while the serum level of IL-17 in COVID-19 patients was significantly higher than that of healthy individuals. These findings suggest that low numbers of Th17 cells and insufficient levels of IL-17 may be predisposing factors for the development of mucormycosis during or after COVID-19 infection.
Review
Immunology
Kathryne E. Marks, Deepak A. Rao
Summary: Pathologic T cell-B cell interactions play a crucial role in autoimmune diseases. Tph cells, a unique subset of T cells, have been identified in autoantibody-associated diseases, providing both B cell help and the ability to migrate to inflamed peripheral tissues. Understanding and tracking Tph cells are crucial for studying the pathogenesis and therapeutic strategies of autoimmune diseases.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Jinling Huang, Hae-youn Lee, Xiaohong Zhao, Jinyi Han, Yang Su, Qinli Sun, Jing Shao, Jiwan Ge, Yuxi Zhao, Xue Bai, Yi He, Xinquan Wang, Xiaohu Wang, Chen Dong
Summary: The poorly understood member IL-17D in the IL-17 family plays a crucial role in maintaining intestinal homeostasis by regulating ILC3 function. Its deficiency leads to increased susceptibility to colitis, bacterial infection, and colon cancer. IL-17D binds CD93, a glycoprotein on mature ILC3s, and the IL-17D-CD93 axis is crucial in preserving intestinal health.
Article
Infectious Diseases
Gui-Ling Chen, Xiao-Feng Li, Xia-Hong Dai, Nan Li, Meng-Li Cheng, Zhen Huang, Jian Shen, Yu-Hua Ge, Zhen-Wei Shen, Yong-Qiang Deng, Shu-Yuan Yang, Hui Zhao, Na-Na Zhang, Yi-Fei Zhang, Ling Wei, Kai-Qi Wu, Meng-Fei Zhu, Cong-Gao Peng, Qi Jiang, Shou-Chun Cao, Yu-Hua Li, Dan-Hua Zhao, Xiao-Hong Wu, Ling Ni, Hua-Hao Shen, Chen Dong, Bo Ying, Guo-Ping Sheng, Cheng-Feng Qin, Hai-Nv Gao, Lan-Juan Li
Summary: This study evaluated the preliminary safety, tolerability, and immunogenicity of an mRNA vaccine (ARCoV) encoding the receptor-binding domain of the SARS-CoV-2 spike protein. The results showed that ARCoV was safe and well-tolerated at all doses and induced strong humoral and cellular immune responses. These findings support further clinical testing of ARCoV on a large scale.
Editorial Material
Medicine, General & Internal
Xin Wu, Huji Xu, Chen Dong
CHINESE MEDICAL JOURNAL
(2022)
Article
Biology
Han Feng, Xiaohong Zhao, Jenny Xie, Xue Bai, Weiwei Fu, Hairong Chen, Hong Tang, Xiaohu Wang, Chen Dong
Summary: This study systematically compared the transcriptomic profiles of Tfh cells from different types of immune responses and found differential induction of gene clusters corresponding to effector Th cells. It also discovered a subset of Tfh cells producing IFN-gamma in influenza virus infection, which had a unique developmental regulation. Selective ablation of these cells impaired immune response and control of infection.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Editorial Material
Biology
Xinyi Guo, Chen Dong
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Shanjuan Hong, Qing Yuan, Haizhui Xia, Yuan Dou, Tiantian Sun, Tian Xie, Zhiyin Zhang, Wei He, Chen Dong, Jian Lu, Li Guo, Ling Ni
Summary: This study established an ex vivo cultured tumor tissue model to evaluate the efficacy of a VISTA inhibitor in treating clear cell renal cell carcinoma (ccRCC). The results showed that all tested patients responded to the anti-VISTA antibody, while only a small fraction responded to the anti-PD-1 antibody. Co-blockade of VISTA and PD-1 had a synergistic effect in 20% of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinwei Liu, Jing Hao, Peng Wei, Xiaohong Zhao, Qiuyan Lan, Lu Ni, Yongzhen Chen, Xue Bai, Ling Ni, Chen Dong
Summary: In this study, the researchers found that SMAD4 plays a critical role in promoting CD8(+) T cell function in both tumor and infection models. SMAD4-mediated transcriptional regulation enhances CD8(+) T cell activation and cytotoxicity through the T cell receptor (TCR) signaling pathway. Furthermore, SMAD4 is directly phosphorylated by ERK following TCR activation.
Review
Allergy
Han Feng, Zixuan Zhao, Chen Dong
Summary: This article reviews the plasticity of T-FH cells in various types of immune responses and highlights their important implications in understanding and treating human diseases, particularly allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xinhui Ni, Yi Xu, Wang Wang, Baida Kong, Jian Ouyang, Jiwei Chen, Man Yan, Yawei Wu, Qi Chen, Xinxin Wang, Hongquan Li, Xiaoguang Gao, Hongquan Guo, Lian Cui, Zeyu Chen, Yuling Shi, Ronghui Zhu, Wei Li, Tieliu Shi, Lin-Fa Wang, Jinling Huang, Chen Dong, Yuping Lai
Summary: This study found that the RNA helicase DDX5 plays an important role in inflammatory skin disorders. DDX5 expression was downregulated in keratinocytes from patients with atopic dermatitis and psoriasis. Mice with keratinocyte-specific deletion of DDX5 were more susceptible to cutaneous inflammation. Inhibition of DDX5 led to pre-messenger RNA splicing events that favored the production of membrane-bound IL-36 receptor and selective amplification of IL-36R-mediated inflammatory responses and cutaneous inflammation.
Article
Multidisciplinary Sciences
Xinxin Chi, Wei Jin, Xiaohong Zhao, Tian Xie, Jing Shao, Xue Bai, Yu Jiang, Xiaohu Wang, Chen Dong
Summary: This study reveals the dual crucial functions of RORγt in effector T(H)17 cells, maintaining the T(H)17 cell program and constraining the conversion to T(H)2 cells. The loss of RORγt leads to closed chromatin configuration and inhibits Il4 transcription. These findings provide previously unidentified considerations in therapeutic targeting of RORγt.
Article
Immunology
Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong
Summary: Sun et al. discovered that STAT3, activated by IL-10 and IL-21, plays crucial roles in the terminal differentiation of effector CD8(+) T cells in cancer and acute infection. STAT3 enhances effector functions and survival of T-ex(term) cells in the tumor microenvironment, leading to improved tumor control. It transcriptionally promotes effector function-related genes and collaborates with BATF and IRF4 to mediate chromatin activation at effector gene loci.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Yuling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, Bowen Xie, Jinling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, Chen Dong
Summary: Yuling Li et al. found that BCL6 is selectively expressed in CCR6(+) ILC3 among the ILC family. BCL6 expression, induced by intestinal microbiota, restrains the effector function and plasticity of CCR6(+) ILC3.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Adithap Hansakon, Chumpol Ngamphiw, Sissades Tongsima, Pornpimon Angkasekwinai
Summary: Cryptococcal meningoencephalitis caused by Cryptococcus neoformans infection is the most common cause of death in HIV/AIDS patients. Macrophages play a key role in regulating immune responses to cryptococcal infection, but the mechanisms underlying macrophage responses to C. neoformans remain unclear.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Peerapong Kamjai, Sivaporn Hemvimol, Narisa Kengtrong Bordeerat, Potjanee Srimanote, Pornpimon Angkasekwinai
Summary: Coronavirus disease 2019 (COVID-19) is a highly contagious viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a challenge to global public health. The study assessed the ability of novel markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein to lymphocyte ratio (CLR), in screening and predicting types of oxygen therapy in COVID-19 patients. The results identified potential markers to differentiate the suitable management of oxygen therapy in COVID-19 patients for improving disease outcomes with limited respiratory support resources.
Article
Medicine, Research & Experimental
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihon Song, Xin Wang
Summary: Down syndrome is one of the critical risk factors for early-onset Alzheimer's disease, and the DS-related gene USP25 has been identified as a critical regulator of AD pathology, potentially serving as a pharmacological target for AD drug development.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
