Review
Biochemistry & Molecular Biology
Naina Mohamed Pakkir Maideen, Rajkapoor Balasubramanian, Sudha Muthusamy
Summary: This study reviewed the drug interactions of loop diuretics with other medications. Loop diuretics are associated with hypokalemia and ototoxicity and can interact pharmacodynamically with various drugs. Understanding these interactions is crucial for clinicians, pharmacists, and other healthcare providers.
CURRENT DRUG METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Athanasios Manolis, Manolis Kallistratos, Michael Doumas
Summary: Loop diuretics are recommended for heart failure patients by ESC to reduce hospitalizations and improve symptoms and exercise capacity. Torasemide is recommended for the first time in hypertensive patients by ESH guidelines. This review emphasizes the importance of torasemide in the management of arterial hypertension and heart failure.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Marco De Giovanni, Hanson Tam, Colin Valet, Ying Xu, Mark R. Looney, Jason G. Cyster
Summary: The G-protein-coupled receptor GPR35 is upregulated in activated neutrophils and plays a crucial role in their migration. The platelet-derived serotonin metabolite 5-HIAA acts as a ligand for GPR35 and promotes neutrophil recruitment to sites of inflammation via platelets and mast cells.
Article
Immunology
Tianyin Sun, Ruiqian Xie, Hongbin He, Qianqian Xie, Xueqin Zhao, Guijie Kang, Chen Cheng, Wenwei Yin, Jingjing Cong, Jing Li, Xuefu Wang
Summary: Kynurenic acid (KA) inhibits activation of the NLRP3 inflammasome through reducing calcium mobilization and mitochondrial damage, thus preventing inflammation and metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Graeme Milligan
Summary: Despite being poorly characterised, orphan G-protein-coupled receptor 35 (GPR35) has attracted significant interest as a therapeutic target. Differences in pharmacology between human and rodent orthologues of the receptor have restricted preclinical disease models, but recent developments in ligands, transgenic mouse models, and analysis of single-nucleotide polymorphisms (SNPs) have improved understanding and stimulated disease-targeted proof-of-concept studies. This opinion article provides new insights into the biology of GPR35 and discusses its therapeutic potential in various diseases.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xinheng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang
Summary: This study reports the cryo-electron microscopy structure of GPR35 coupled with G(13) and bound to the anti-allergic drug lodoxamide. The structure reveals a novel divalent cation coordination site and a unique ionic regulatory mode of GPR35, providing insights into its ligand binding promiscuity. Structural comparison with other G protein subtypes-coupled GPCRs highlights significant movements in the G alpha(13) subunit and the GPR35 TM6 helix.
Article
Cardiac & Cardiovascular Systems
Arti V. Virkud, Patricia P. Chang, Michele Jonsson Funk, Abhijit V. Kshirsagar, Jessie K. Edwards, Virginia Pate, Michael R. Kosorok, Emily W. Gower
Summary: This study compared the effects of prescribing different loop diuretics (torsemide, furosemide, and bumetanide) at the time of hospital discharge for heart failure patients. The results showed that torsemide had the lowest risk of all-cause mortality and combined outcomes, while bumetanide had a slightly higher risk compared to furosemide.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Review
Chemistry, Medicinal
Dong-Soon Im
Summary: GPR35, an orphan receptor, has been found to have 5-HIAA as a high potency ligand, and a transgenic knock-in mouse line with human ortholog of GPR35 has been developed for therapeutic experiments. This article reviews the recent advances and prospective therapeutic directions in GPR35 research.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Oncology
Jun Li, Gang Peng, Kuikui Zhu, Xiaohua Jie, Yingzhuo Xu, Xinrui Rao, Yunhong Xu, Yunshang Chen, Biyuan Xing, Gang Wu, Liangliang Shi
Summary: This study found that mast cells are poor prognostic factors associated with resistance to anti-PD-1 immunotherapy. The PD-1 antibody can activate PD-1(+) mast cells to release histamine and cytokines, thereby playing a negative role in the tumor microenvironment. Inhibition of mast cells may provide a new solution to improve the response rate of anti-PD-1 immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Jan Biegus, Robert Zymlinski, Jeffrey Testani, Marat Fudim, Zachary L. Cox, Mateusz Guzik, Gracjan Iwanek, Magdalena Hurkacz, Danuta Raj, Dominik Marciniak, Barbara Ponikowska, Piotr Ponikowski
Summary: The diuretic response is poorer in patients with chronic use of loop diuretics compared to those who are new users, and this is due to decreased tubular responsiveness rather than insufficient furosemide tubular delivery. The study found that furosemide naive patients had significantly better diuresis and natriuresis compared to chronic furosemide users. Although the urine furosemide delivery was similar in both groups, the tubular response to the delivered diuretic was significantly higher in furosemide naive patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Betuel Karayay, Heidi Olze, Agnieszka J. Szczepek
Summary: Our research group discovered resident mast cells in rodents' cochleae and found that adding cisplatin changed their number. We further observed that murine cochlear mast cells degranulate in response to cisplatin and that the mast cell stabilizer cromolyn inhibits this process. Additionally, cromolyn significantly prevented cisplatin-induced loss of auditory hair cells and spiral ganglion neurons, providing evidence for mast cell participation in cisplatin-induced damage to the inner ear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Tianshu Shi, Yong Shi, Hongliang Gao, Yuze Ma, Qianjin Wang, Siyu Shen, Xiaoyan Shao, Wang Gong, Xiang Chen, Jian Qin, Jing Wu, Qing Jiang, Bin Xue
Summary: The serum level of muscle-derived kynurenic acid (Kyna) is lower in postmenopausal osteoporosis (PMOP) model mice. Exercise and exogenous Kyna treatment can alleviate the effects of PMOP through the Gpr35 receptor.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Critical Care Medicine
Jean-Maxime Cote, Josee Bouchard, Patrick T. Murray, William Beaubien-Souligny
Summary: Continuous loop-diuretic infusion and combinations of loop diuretics with thiazide or carbonic anhydrase inhibitors significantly increased urine output, resulting in negative fluid balance and weight loss. Conversely, intravenous albumin administration was associated with fluid gain.
JOURNAL OF CRITICAL CARE
(2021)
Article
Biochemistry & Molecular Biology
Di Wang, Wenbao Wang, Xue Bing, Chenguang Xu, Jiahua Qiu, Jiangang Shen, Jinwen Huang, Junda Li, Pi Liu, Biao Xie
Summary: In this study, the researchers established a rat model of colitis and used 16S rRNA sequencing to explore the impact of GPR35-mediated KA sensing on gut microbiota homeostasis. The results showed that GPR35-mediated KA sensing is essential for maintaining gut barrier integrity and alleviating DSS-induced colitis. Additionally, specific bacterial taxa were identified as markers of colitis progression and outcome, regulated by GPR35-mediated KA sensing.