Article
Food Science & Technology
Wenya Jiao, Yaxin Sang, Xianghong Wang, Shuo Wang
Summary: This study explored the hypoglycemic mechanism of 6-shogaol from the perspective of glucose uptake, absorption transport, and protection of intestinal barrier function. The findings showed that 6-shogaol effectively inhibits the activity of alpha-glucosidase, reduces glucose uptake, down-regulates the expression of glucose transporters, and promotes the up-regulation of tight junction proteins, protecting the intestinal barrier function and promoting intestinal material absorption.
Article
Biochemistry & Molecular Biology
Yunqing Wang, Ganwarige Sumali N. Fernando, Natalia N. Sergeeva, Nikolaos Vagkidis, Victor Chechik, Thuy Do, Lisa J. Marshall, Christine Boesch
Summary: The present study compared the absorption and transport patterns of three main betalains, betanin, vulgaxanthin I, and indicaxanthin, in intestinal epithelial cells. The results showed that these compounds have different molecular effects on inflammatory and redox-related cell signaling. Betanin demonstrated a potent dose-dependent radical scavenging activity.
Article
Multidisciplinary Sciences
Irati Aiestaran-Zelaia, Maria Jesus Sanchez-Guisado, Marina Villar-Fernandez, Mikel Azkargorta, Lucia Fadon-Padilla, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Pedro Ramos-Cabrer, Antonella Spinazzola, Felix Elortza, Jesus Ruiz-Cabello, Ian J. Holt
Summary: 2-Deoxy-D-glucose (2DG) inhibits glycolysis, stimulates respiration, and restricts viral replication in cultured cells. In the murine heart, 2DG increases the respiratory chain proteome of mitochondria, enhancing oxidative capacity and potentially compensating for the energy deficit caused by glycolysis inhibition.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Matusorn Wongon, Nanteetip Limpeanchob
Summary: Oxyresveratrol and Puag Haad can inhibit glucose transporter 2 and sodium-dependent glucose transporter 1, potentially reducing postprandial hyperglycemic peaks in diabetics.
Article
Agriculture, Multidisciplinary
Mengman Zheng, Yi Guo, Wenyun Li, Min Wu, Mingjing Xu, Manman Shao, Gengsheng He, Yuwei Liu
Summary: This study aimed to investigate the impacts of different carrier oils (long chain triglycerides, medium chain triglycerides, and orange oil) on the micellization and cellular uptake of beta-carotene in O/W emulsions, focusing on the role of intestinal transporters. The results showed that medium chain triglyceride emulsion had a significantly higher cellular uptake rate of beta-carotene compared to the other emulsions, while the micellization rate was lower.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Veterinary Sciences
Yeon Chae, Taesik Yun, Yoonhoi Koo, Dohee Lee, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
Summary: This study used FDG-PET/CT to identify physiological FDG uptake in cats and compared it with dogs, revealing differences in brain and digestive system uptake. Understanding these differences can improve cancer diagnosis and glucose metabolism understanding in both cats and dogs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Eiichi Kotake-Nara, Shiro Komba, Megumi Hase
Summary: Vitamins D have various biological activities and there is concern about insufficient intake. The synthesis and evaluation of vitamins D-5 to D-7 showed similar uptake amounts in Caco-2 cells, while lysophosphatidylcholine enhanced absorption. The activated forms of vitamins D-4 to D-7 were predicted to have biological activities, supporting their potential as nutritional components.
Article
Environmental Sciences
Anna Mittag, Christian Hoera, Alexander Kaempfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei
Summary: The study found that zinc oxide nanoparticles of different sizes have cellular uptake and toxic effects on human intestinal cells, especially showing cytotoxicity at high concentrations, which can accelerate cell apoptosis and death.
Article
Biochemistry & Molecular Biology
Josefa Domenech, Mariana de Britto, Antonia Velazquez, Susana Pastor, Alba Hernandez, Ricard Marcos, Constanza Cortes
Summary: The study assessed the long-term effects of polystyrene nanoparticles on human intestinal cells, showing that PSNPs accumulated in cells over time and induced changes at the ultrastructural and molecular levels. However, minor effects were observed in genotoxicity-related biomarkers, indicating no DNA damage or oxidative stress after long-term exposure to PSNPs.
Article
Food Science & Technology
Da-wei Chen, Chun-meng Chen, Heng-xian Qu, Chen-yu Ren, Xian-tao Yan, Yu-jun Huang, Cheng-ran Guan, Chen-chen Zhang, Qi-ming Li, Rui-xia Gu
Summary: This study aimed to screen Lactobacillus strains with strong survivability and adhesion abilities, and investigate their impact on the absorption of SCFAs by epithelial cells. L. plantarum and L. fermentum strains demonstrated higher survival rates in the oro-gastrointestinal tract and enhanced SCFAs uptake by intestinal epithelial cells, suggesting their potential as probiotics for gut health.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandra Flory, Ann-Kathrin Benz, Jan Frank
Summary: This study investigated the uptake and time-dependent localization of curcumin in intestinal cells when administered as native or micellar formulation. The results showed that the uptake and localization of native and micellar curcumin in intestinal cells did not differ significantly, and the temporary co-localization with lysosomes was associated with cellular uptake.
Article
Biochemistry & Molecular Biology
Katharina Hill-Muendel, Donatus Nohr
Summary: Clinical data supporting the efficacy of pharmacological doses of ascorbic acid (AA) in killing cancer cells are still lacking. Inhibition of glycolysis may enhance the anticancer effect of AA by reducing the generation of pyruvate. Experimental results suggest that 2-DG enhances the cytotoxic effect of AA by increasing H2O2 concentration in glycolytic cancer cells, potentially due to lower pyruvate levels as a result of glycolysis inhibition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Zhaoguo Wang, Xiaorui Zhai, Jiayuan Fang, Hongyan Wu, Yunyun Cheng, Yuan Gao, Xi Chen, Shuo Zheng, Songcai Liu, Linlin Hao
Summary: This study extracted antler bone calcium (AB-Ca) and bioactive peptides (ABPs) from antler bones (Cervus elaphus) and found that the peptide-calcium chelate can significantly increase calcium transport. In a mouse model, the combination of AB-Ca and ABPs increased bone formation and inhibited bone resorption, which is beneficial for ameliorating senile osteoporosis.
Review
Pharmacology & Pharmacy
Zoufang Huang, Vivek P. Chavda, Lalitkumar K. Vora, Normi Gajjar, Vasso Apostolopoulos, Nirav Shah, Zhe-Sheng Chen
Summary: There is a lack of adequate treatment choices for COVID-19, and no established intervention has effectively reduced mortality rate. Recent studies have shown that 2-deoxy-D-glucose (2-DG) could aid in faster recovery and reduce the need for supplemental oxygen in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Hanne Vissenaekens, Guy Smagghe, Hanne Criel, Charlotte Grootaert, Katleen Raes, Andreja Rajkovic, Geert Goeminne, Nico Boon, Kristof De Schutter, John Van Camp
Summary: The study demonstrates that quercetin can partially restore mitochondrial dysfunction, especially FCCP-induced dysfunction, in intestinal cells by accumulating in the mitochondria.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Hematology
Pedro Goncalves, Jean-Marc Doisne, Toshiki Eri, Bruno Charbit, Vincent Bondet, Celine Posseme, Alba Llibre, Armanda Casrouge, Christelle Lenoir, Benedicte Neven, Darragh Duffy, Alain Fischer, James P. Di Santo
Summary: Both innate and adaptive lymphocytes play critical roles in mucosal defense. SCID patients receiving HSCT may have impaired lymphocyte regeneration. SCID patients with IL2RG/GC or JAK3 genetic defects exhibit defects in mucosal immunity and IgA production, leading to microbial dysbiosis. IVIG replacement therapy can partially restore these immune defects.
Article
Biochemistry & Molecular Biology
Claudia Silva, Nelson Andrade, Joao Tiago Guimaraes, Emilia Cardoso, Catarina Meireles, Vanessa Pinto, Joana Paiva, Fatima Martel
Summary: Type 2 diabetes is associated with an increased risk of breast cancer. Hyperinsulinemia, a characteristic of T2DM, promotes breast cancer by increasing glucose uptake through a PI3K and mTOR-dependent mechanism.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Reproductive Biology
Ligia Pinto-Ribeiro, Claudia Silva, Nelson Andrade, Fatima Martel
Summary: This study aimed to investigate the effects of oxidative stress on extravillous trophoblasts (EVTs) and the preventive effects of several antioxidant agents. The results showed that oxidative stress interferes with essential characteristics of EVT and may contribute to the development of pregnancy disorders. The efficacy of antioxidants is influenced by the nature of the oxidative stress induction model.
REPRODUCTIVE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicolas Serafini, Angelique Jarade, Laura Surace, Pedro Goncalves, Odile Sismeiro, Hugo Varet, Rachel Legendre, Jean-Yves Coppee, Olivier Disson, Scott K. Durum, Gad Frankel, James P. Di Santo
Summary: Group 3 innate lymphoid cells (ILC3s) in the intestine remain activated for months after exposure to Citrobacter rodentium, leading to enhanced immune response and defense capability. These trained ILC3s undergo metabolic changes and exhibit enhanced proliferative capacity and IL-22 production.
Article
Oncology
F. Carmo, C. Silva, F. Martel
Summary: Breast cancer, as the most incident cancer, can be effectively inhibited by targeting the uptake of glutamine, especially for triple-negative breast cancer, with xanthohumol, a polyphenol, showing promising potential as an inhibitor.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Food Science & Technology
Juliana A. Barreto Peixoto, Nelson Andrade, Susana Machado, Anabela S. G. Costa, Helder Puga, Maria Beatriz P. P. Oliveira, Fatima Martel, Rita C. Alves
Summary: This study investigates the possibility of recovering bioactive compounds from coffee silverskin using a sustainable extraction method and testing their effects on human intestinal cells. The results indicate that the Multi-frequency Multimode Modulated technology can be applied at an industrial level to obtain extracts with antidiabetic potential from silverskin.
Review
Pharmacology & Pharmacy
Joaquim S. Pinto, Fatima Martel
Summary: This systematic review examines the potential effects of cannabidiol on appetite and body weight. The results suggest that cannabidiol may have an anorexigenic effect and lead to a decrease in body weight. However, the included studies had some concerns regarding risk of bias. Further research is needed to clarify the potential mechanisms of cannabidiol on feeding and appetite.
CLINICAL DRUG INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Maria A. Vieira-Coelho, Fatima Martel
Summary: Fluoxetine, a commonly used antidepressant, has been found to modulate K+ channel activity in the kidneys of rats. In vivo studies showed that fluoxetine significantly reduced urinary K+ content and fractional renal excretion of K+. In vitro experiments demonstrated that fluoxetine inhibited K+ currents in kidney epithelial cells.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Silvia M. Torres, Francisca P. Carmo, Luis C. Monteiro, Claudia Silva, Nelson Andrade, Fatima Martel
Summary: Phenolic acids have been recognized as effective agents for chemoprevention and chemotherapy. This study aimed to investigate the impact of phenolic acids on glucose and glutamine uptake in breast cancer cells (MCF-7) and pancreatic cancer cells (AsPC-1). The results showed that certain phenolic acids affected the uptake of both 3H-glutamine and 3H-deoxy-D-glucose (3H-DG).
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Food Science & Technology
Iohanna Deckmann, Julio Santos-Terra, Fatima Martel, Jaqueline Vieira Carletti
Summary: This article reviews the effects of polyphenols intake during pregnancy on three common pregnancy-associated complications: preeclampsia, gestational diabetes, and fetal growth restriction. The analysis includes studies conducted in human, animal, and in vitro models, highlighting the protective effects of polyphenols. The review provides a critical analysis of the literature and a summary of evidence for future research and evaluation using polyphenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Ariana C. F. Santos, Fatima Martel, Carmen S. R. Freire, Barbara J. M. L. Ferreira
Summary: This article reviews different case studies targeting polymeric materials and their application in combating RNA viruses in different stages.
BIOENGINEERING-BASEL
(2022)
Review
Biotechnology & Applied Microbiology
Diogo Marinheiro, Fatima Martel, Barbara J. M. L. Ferreira, Ana L. L. Daniel-da-Silva
Summary: Diabetes mellitus, a global epidemic, is associated with serious health threats including cardiovascular diseases. Current treatments have limitations, driving the development of new effective formulations. Silica-based nanocarriers show potential for treating diabetes and regulating blood glucose concentration due to their tunable characteristics. This review discusses topics such as oral insulin administration, glucose-responsive devices, and innovative drug delivery routes.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Mafalda Couto, Nelson Andrade, Fernando Magro, Fatima Martel
Summary: Inflammatory bowel disease (IBD) is a chronic and life-threatening inflammatory disease of the gastrointestinal tract. Reduced absorption of bile salts and impaired utilization of butyrate in the inflamed mucosa are believed to be related to the pathophysiology of IBD. Pro-inflammatory cytokines TNF-a and IFN-? inhibit the uptake of 3H-TC by Caco-2 cells, and BT also shows an inhibitory effect on 3H-TC uptake and enhances the effect of IFN-?.
Article
Oncology
Mafalda R. Couto, Nelson Andrade, Fernando Magro, Fatima Martel
Summary: This study investigates the interaction between inflammatory bowel disease and colorectal cancer, finding that the presence of proinflammatory cytokines and bile acids inhibits the uptake of butyrate by Caco-2 cells, contributing to the link between these two diseases.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Maria Fonseca, Francisca Carmo, Fatima Martel
Summary: Atypical antipsychotics (AAPs) have beneficial effects in treating mental diseases, but they also have undesired metabolic side effects. These side effects are related to the actions of AAPs in metabolic organs and the central and peripheral nervous system. A better understanding of the molecular targets and mechanisms linking AAPs with metabolic syndrome is necessary to develop AAPs with less adverse effects.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)