期刊
TUMOR BIOLOGY
卷 36, 期 11, 页码 8697-8702出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3623-8
关键词
miR-503; Breast cancer; CCND1; Cell proliferation; Cell cycle
类别
资金
- Science and Technology Planning Project of Guangdong Province [2012B031800055]
- National Natural Science Foundation of China [31400858]
Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G(0)/G(1) cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.
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