Article
Chemistry, Multidisciplinary
Xiao-liang Dong, Bao-hui Yuan, Sheng-zhou Yu, He Liu, Xiao-hua Pan, Jia Sun, Li-long Pan
Summary: Long-term treatment with adriamycin (ADR) can lead to cardiac fibrosis, and PRMT5 plays a role in this process by activating cardiac fibroblasts and promoting ADR-induced cardiac fibrosis. PRMT5 may be a potential therapeutic target for ADR-caused cardiotoxicity.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Li-Fei Luo, Peng Guan, Lu-Yun Qin, Jian-Xin Wang, Na Wang, En-Sheng Ji
Summary: The study demonstrated that Astragaloside IV (AsIV) protected rats against adriamycin (ADR)-induced cardiomyopathy by suppressing oxidative stress and enhancing Nrf2 signaling pathway, indicating its potential as a protective agent in myocardial fibrosis induced by ADR.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Wenci Weng, Xuewen Yu, Yifan Dong, Taifen Wang, Mumin Shao, Huili Sun, Pengxun Han
Summary: Adriamycin is an effective antitumor drug, but it has various side effects, such as irreversible cardiotoxicity. The study investigated the effects of artemether on Adriamycin-induced cardiotoxicity and found that artemether could prevent cardiac atrophy and regulate the autophagy pathway. The findings suggest that artemether could be used as a therapeutic approach to prevent drug-induced heart diseases.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Yue Zhang, Zhiying Wang, Dingming Lan, Jingjing Zhao, Lexun Wang, Xiaoqi Shao, Dongwei Wang, Kaili Wu, Mengxian Sun, Xueying Huang, Meiling Yan, Haihai Liang, Xianglu Rong, Hongtao Diao, Jiao Guo
Summary: MiR-24-3p expression is downregulated in cardiac fibrosis and its forced expression can inhibit fibroblast proliferation and migration, as well as reduce collagen and alpha-SMA levels. MiR-24-3p can alleviate cardiac fibrosis by suppressing mitophagy and autophagic flux.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Analytical
Braulio C. L. B. Ferreira, Piumi Y. Liyanage, Roger M. Leblanc
Summary: Nanoparticle drug delivery systems are currently a focus of nanomedicine studies, particularly in oncology where quantification of drug administration level is crucial for dosage and quality control of treatments. The proposed analytical protocol using circular dichroism spectrometry provides a feasible pathway to improve nano drug quantification procedures for different anthracycline drugs.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Jose Miguel Osorio, Claudio Espinoza-Perez, Constanza Rimassa-Tare, Victor Machuca, Juan Ortega Bustos, Matias Vallejos, Hector Vargas, Guillermo Diaz-Araya
Summary: Cardiac fibroblasts play a central role in the development of cardiac fibrosis and can become senescent, leading to organ dysfunction. Early senescence in cardiac fibroblasts after myocardial infarction seems to be protective, but in non-infarcted models, it can be deleterious. New drugs called senolytics and senostatics have emerged as potential therapeutical strategies for treating aging-related cardiac pathologies, but more research is needed to determine their effectiveness in different pathological contexts and timings of intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pharmacology & Pharmacy
Yan Chen, Junteng Zhou, Zisong Wei, Yue Cheng, Geer Tian, Yue Quan, Qihang Kong, Wenchao Wu, Xiaojing Liu
Summary: Cardiac hypertrophy initially serves as an adaptive response to physiological and pathological stimuli. However, sustained hypertrophy leads to pathological cardiac hypertrophy, cardiac fibrosis, and ultimately heart failure. Recent studies have highlighted the importance of circRNA and its regulation of mRNA in the posttranscriptional regulation of cardiac hypertrophy. This study identifies differentially expressed circRNAs and explores their coexpression with mRNAs and miRNAs, providing potential targets for the treatment of pathological cardiac hypertrophy and fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Abolfazl Khajavi Rad, Samira Shahraki, Zohreh Naji Ebrahimi Yazd, Alireza Ebrahimzadeh Bideskan, Mahdiyeh Hedayati-Moghadam, Zahra Samadi Noshahr, Sara Hosseinian
Summary: The study showed that PM extract had a protective effect against ADR-induced renal fibrosis in rats by reducing the expression of fibrotic markers and interstitial fibrosis in kidney tissue.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kazuaki Maruyama, Kyoko Imanaka-Yoshida
Summary: Fibrosis is the excessive deposition of extracellular matrix (ECM) proteins in the interstitium, which is a pathological response to chronic inflammation. Although initially protective, excessive and continuous tissue damage and deposition lead to distorted organ structure and significant impact on cardiac function. This review summarizes the histologic features of cardiac fibrosis, the signaling factors that control it, the origin and characteristic markers of cardiac fibroblasts, and the growing importance of lymphatic vessels in improving cardiac fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Nikolaos G. Frangogiannis
Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.
CARDIOVASCULAR RESEARCH
(2021)
Review
Genetics & Heredity
Junjie Liu, Ximao Liu, Yucheng Luo, Fangze Huang, Yu Xie, Shaoyi Zheng, Bo Jia, Zezhou Xiao
Summary: Sphingolipids play a crucial role in tissue fibrosis, including cardiac fibrosis, and are important for the development of atrial fibrillation. Understanding the impact of sphingolipid levels on cardiac fibrosis can lead to innovative therapeutic strategies for addressing fibrosis and atrial fibrillation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jie Xu, Jinghuan Wang, Fen Long, Wen Zhong, Haibi Su, Zhenghua Su, Xinhua Liu
Summary: The upregulation of Dot1L activates cardiac fibroblasts to promote profibrotic gene expression, leading to cardiac fibrosis. Pharmacological targeting of Dot1L could be a promising therapeutic approach for the treatment of human cardiac fibrosis and other fibrotic diseases.
CELL AND BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Akito Eguchi, Ryan Coleman, Kenneth Gresham, Erhe Gao, Jessica Ibetti, J. Kurt Chuprun, Walter J. Koch
Summary: Pathological remodeling of the heart in chronic heart failure is linked to structural changes perpetuated by cardiac fibroblasts, with GRK5 playing a key role in regulating fibroblast activation and cardiac fibrosis. GRK5 inhibition shows potential beneficial effects in cardiac disease by preventing fibroblast activation and reducing fibrosis and hypertrophy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Physics, Multidisciplinary
Farhad Pashakhanloo, Alexander V. Panfilov
Summary: Cardiac fibrosis is a well-known arrhythmogenic condition that can lead to sudden cardiac death. The concept of minimal functional cluster accurately characterizes the path of reexcitation and quantitatively predicts the reentry probability. Fibrosis density and tissue excitability affect the probability of reentry.
PHYSICAL REVIEW LETTERS
(2021)