Article
Biochemistry & Molecular Biology
Nives Skorja Milic, Klemen Dolinar, Katarina Mis, Urska Matkovic, Marusa Bizjak, Mojca Pavlin, Matej Podbregar, Sergej Pirkmajer
Summary: Inhibition of pyruvate dehydrogenase kinase (PDK) by Dichloroacetate (DCA) can reduce the abundance of PDK isoenzymes in a cell-type-specific manner via both transcriptional and post-transcriptional mechanisms. The differential response of PDK isoenzymes to DCA in cancer cells and muscle cells highlights the importance of understanding the pharmacological effects of DCA in different cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Review
Biochemistry & Molecular Biology
Zhou Yang, Guang-li Yu, Xiao Zhu, Tian-hong Peng, Yun-cheng Lv
Summary: FTO mediates m(6)A demethylation to modulate lipid metabolism by affecting gene expression, leading to alterations in lipid synthesis, storage, and utilization.
Review
Medicine, Research & Experimental
Russel J. Reiter, Ramaswamy Sharma, Carmen Rodriguez, Vanesa Martin, Sergio Rosales-Corral, Debora Aparecida Pires de Campos Zuccari, Luiz Gustavo de Almeida Chuffa
Summary: This paper explores the relationship between endogenous melatonin and solid tumors, highlighting the potential of using melatonin to influence cancer cell metabolism. It suggests that solid tumors exhibit a healthier metabolic state at night, potentially reducing proliferation and invasiveness. The paper also proposes using melatonin in a time-sensitive treatment paradigm and combining it with traditional chemotherapy for improved outcomes in cancer treatment.
Article
Cell Biology
Jennifer Maurer, Xinjie Zhao, Martin Irmler, Anders Gudiksen, Nanna S. Pilmark, Qi Li, Thomas Goj, Johannes Beckers, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Andreas Peter, Rainer Lehmann, Henriette Pilegaard, Kristian Karstoft, Guowang Xu, Cora Weigert
Summary: Metformin treatment leads to lactate production and secretion, as well as reduced glucose consumption. It inhibits respiratory chain complex I and alters cellular redox state, decreasing pyruvate oxidation. These findings suggest that metformin induces dose-dependent lactate production in skeletal muscle by shifting the equilibrium of lactate dehydrogenase reaction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Dingbang Xie, Yunteng Xu, Yimin Zhang, Wanping Cai, Xin Lan, Hui Yan
Summary: Postmenopausal osteoporosis (PMOP) is characterized by an imbalance between bone formation and bone resorption. In this study, it was found that icariin (ICA) could alleviate PMOP by inhibiting pyruvate dehydrogenase kinase 1 (PDK1) in osteoclasts, indicating its potential for clinical use.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Sheng An, Yi Yao, Hongbin Hu, Junjie Wu, Jiaxin Li, Lulan Li, Jie Wu, Maomao Sun, Zhiya Deng, Yaoyuan Zhang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng
Summary: The increase of lactate is an independent risk factor for sepsis-induced acute kidney injury (SAKI). The downregulation of deacetylase Sirtuin 3 (SIRT3) leads to excessive lactate production and exacerbates renal injury. Through the regulation of lactate levels and mitochondrial protein Fis1 lactylation, the severity of SAKI can be alleviated.
CELL DEATH & DISEASE
(2023)
Editorial Material
Endocrinology & Metabolism
Philippe Icard, Luca Simula
Summary: We discuss the metabolism changes that occur during different phases of the cell cycle to support biosynthesis and replication in normal and cancer cells. We also highlight the role of several master regulators, including cyclin-cyclin-dependent kinases (cyc-CDK complexes) and E3 proteasome ligases, in modulating key metabolic enzymes for cell cycle progression.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Nicholas L. Arp, Gretchen L. Seim, James A. Votava, Jordyn Josephson, Jing Fan
Summary: This study revealed a new mechanism for BCKDC regulation and demonstrated the broad inhibitory effects of RNS on all alpha-ketoacid dehydrogenases. It has significant physiological implications for multiple cell types and elucidates the mechanistic connection between RNS-driven inhibitory modifications on the E2 and E3 subunits of alpha-ketoacid dehydrogenases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Qinfeng Li, Chao Li, Abdallah Elnwasany, Gaurav Sharma, Yu A. An, Guangyu Zhang, Waleed M. Elhelaly, Jun Lin, Yingchao Gong, Guihao Chen, Meihui Wang, Shangang Zhao, Chongshan Dai, Charles D. Smart, Juan Liu, Xiang Luo, Yingfeng Deng, Lin Tan, Shuang-Jie Lv, Shawn M. Davidson, Jason W. Locasale, Philip L. Lorenzi, Craig R. Malloy, Thomas G. Gillette, Matthew G. Vander Heiden, Philipp E. Scherer, Luke I. Szweda, Guosheng Fu, Zhao V. Wang
Summary: PKM1 plays a crucial role in maintaining a homeostatic response in the heart under hemodynamic stress, protecting against cardiac dysfunction and fibrosis caused by pressure overload. Furthermore, PKM1 is essential for enhancing glycolytic flux, mitochondrial respiration, and ATP production under pressure overload at a mechanistic level.
Article
Pharmacology & Pharmacy
Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
Summary: The present study reveals the therapeutic potential of celastrol in attenuating obesity and insulin resistance by improving glucose utilization and mitochondrial oxidative metabolism. Celastrol administration increased the activity of key enzymes and altered the levels of metabolites involved in glycolysis and TCA cycle. It also enhanced the activity of mitochondrial oxidative functions and promoted ATP production and mitochondrial biogenesis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Jae-Han Jeon, Themis Thoudam, Eun Jung Choi, Min-Ji Kim, Robert A. Harris, In-Kyu Lee
Summary: Good health relies on maintaining metabolic flexibility, which is influenced by the regulation of a large number of enzymes, particularly the pyruvate dehydrogenase complex (PDC) in carbohydrate metabolism. The flexibility in PDC regulation depends on the balance between pyruvate dehydrogenase kinases (PDKs) and pyruvate dehydrogenase phosphatases. Overexpression of PDK4 leading to PDC inactivation contributes to hyperglycemia and serious health issues like diabetes. Other diseases such as cancers, non-alcoholic fatty liver disease, and sepsis also show loss of regulatory flexibility in PDC.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Cell Biology
Penghua Fang, Yuqing She, Mei Yu, Wen Min, Wenbin Shang, Zhenwen Zhang
Summary: Obesity and type 2 diabetes contribute significantly to the burden of age-related metabolic diseases globally. Adipose-muscle crosstalk, primarily mediated by myokines and adipokines, plays a crucial role in regulating metabolic responses in skeletal muscle and adipose tissue. However, the detailed mechanisms of adipose-muscle crosstalk in age-related metabolic diseases remain unclear. This review highlights the importance of adipokines adiponectin and spexin, and myokines irisin and interleukin-6 (IL-6) in maintaining metabolic balance and proposes that exercise and dietary flavonoid consumption may modulate adipose-muscle crosstalk, leading to remission of age-related metabolic disorders.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Asen Georgiev, Cesare Granata, Michael Roden
Summary: Common metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease are associated with insulin resistance and mitochondrial dysfunction. Changes in mitochondrial features may reflect adaptation to a certain metabolic condition rather than abnormalities. Lifestyle modifications and drug treatments can help improve these metabolic diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tao Si, Xuejian Ning, Hongwei Zhao, Mingmin Zhang, Ping Huang, Zhengguo Hu, Liu Yang, Lizhu Lin
Summary: The study found that miR-9-5p promotes proliferation, invasion, and migration of HCC cells by regulating the expression of PDK4, enhancing mitochondrial activity and energy metabolism, while suppressing apoptosis, ultimately increasing tumorigenicity in mouse xenograft models. This suggests that miR-9-5p and PDK4 could be potential therapeutic targets for preventing recurrence and metastasis of HCC.
CANCER GENE THERAPY
(2021)
Article
Nanoscience & Nanotechnology
M. Gulrez Zariwala, Harshada Bendre, Anatoliy Markiv, Sebastien Farnaud, Derek Renshaw, Kevin M. G. Taylor, Satyanarayana Somavarapu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Biophysics
Hisham Al-Obaidi, Radoslaw M. Kowalczyk, Rachith Kalgudi, Mohammed Gulrez Zariwala
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Neurosciences
Leah Mursaleen, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala
JOURNAL OF PARKINSONS DISEASE
(2020)
Article
Engineering, Chemical
Nishay Patel, Mohammed Gulrez Zariwala, Hisham Al-Obaidi
Article
Biochemistry & Molecular Biology
Helena Tiekou Lorinczova, Owen Fitzsimons, Leah Mursaleen, Derek Renshaw, Gulshanara Begum, Mohammed Gulrez Zariwala
Article
Biochemistry & Molecular Biology
Leah Mursaleen, Brendon Noble, Stefanie Ho Yi Chan, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala
Article
Cell Biology
Voni Blesia, Vinood B. Patel, Hisham Al-Obaidi, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: Exposure to high levels of iron results in increased cellular iron accumulation, elevated oxidative stress levels, and impaired insulin secretion, leading to compromised viability of pancreatic beta-cells.
Article
Nutrition & Dietetics
Daniel R. Brown, Francesca Cappozzo, Dakota De Roeck, Mohammed Gulrez Zariwala, Sanjoy K. Deb
Summary: Mouth rinsing with a pink non-caloric, artificially sweetened solution can improve self-selected running speed, total distance covered, and feelings of pleasure during a 30 min running protocol.
FRONTIERS IN NUTRITION
(2021)
Article
Physiology
Sanjoy K. Deb, Eimear Dolan, Catherine Hambly, John R. Speakman, Olav Eftedal, Mohammed Gulrez Zariwala, Ingrid Eftedal
Summary: Commercial saturation divers exhibit high daily energy expenditure during diving operations, leading to a negative energy balance, potentially influenced by time spent underwater.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leah Mursaleen, Brendon Noble, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala
Summary: This study successfully incorporated HT and HT+DFO into P68+DQA nanocarriers, enabling enhanced protection against PD-related oxidative stress through BBB model delivery.
Article
Nutrition & Dietetics
Helena Tiekou Lorinczova, Gulshanara Begum, Lina Temouri, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: The aim of this study was to evaluate whether co-administration of ferrous sulphate and formulated curcumin could reduce systemic inflammation and gastrointestinal side-effects. The results showed that the combination of ferrous sulphate and curcumin can reduce inflammation-related markers in the plasma. This supplementation approach may be a more cost-effective and convenient alternative to current oral iron-related treatments, but further research is needed.
Article
Pharmacology & Pharmacy
Hisham Al-Obaidi, Ieva Petraityte, Thomas Hibbard, Mridul Majumder, Rachith Kalgudi, Mohammed Gulrez Zariwala
Summary: This study presents a novel approach to enhance the penetration and antifungal activity of the antifungal drug griseofulvin. The prepared nanosuspensions significantly suppressed fungal activity and showed improved solubility of the drug. The type of surfactant and milling conditions had varied effects on permeability and particle size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Leah Mursaleen, Stefanie Ho Yi Chan, Brendon Noble, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala
Summary: This study investigates the potential of nanocarrier delivery systems, specifically Pluronic(R) F68 (P68) and dequalinium (DQA) nanocarriers, to enhance the brain penetration and targeted delivery of curcumin, N-acetylcysteine (NAC), and/or deferoxamine (DFO). The results show that P68 + DQA nanocarriers significantly increase the passage of curcumin, NAC, and DFO across the blood-brain barrier (BBB) model. These nanocarriers also improve the protective effects of curcumin, NAC, and/or DFO against rotenone-induced toxicity and oxidative stress by targeting mitochondria. This study highlights the potential effectiveness of this nanocarrier strategy in utilizing the therapeutic benefits of these antioxidants.
Article
Chemistry, Applied
Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu
Summary: This study aims to develop dry powder formulations of azithromycin-loaded PLGA nanocomposite microparticles for pulmonary delivery to improve its low bioavailability. The addition of chitosan changed the neutral azithromycin formulation to positively-charged nanoparticles, but also increased the particle size. The dry powder formulations were able to deliver azithromycin to the deep lung regions, demonstrating the potential of using pulmonary drug delivery as an effective method to treat COVID-19.
JOURNAL OF MICROENCAPSULATION
(2023)
Review
Gastroenterology & Hepatology
Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B. Patel
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant global disease burden and a leading cause of mortality. The precise triggers for disease progression and the propagation to cirrhosis are still not fully understood. Treatment options have been explored, but an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)