Article
Plant Sciences
Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh
Summary: The study showed that Gintonin has anti-arthritic effects by inhibiting the expression of inflammatory mediators and preventing the nuclear translocation of NF-kappa B/p65. Additionally, it suppressed arthritis symptoms in a mice model of collagen-induced arthritis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Immunology
Mahmood Ahmad Khan, Gulam Rabbani, Monika Kumari, Mohd Jahir Khan
Summary: The objective of this study was to investigate the anti-inflammatory and anti-arthritic effects of ellagic acid (EA) in collagen-induced arthritis (CIA). The findings demonstrated that EA significantly reduced inflammation and oxidative stress, and inhibited the development of arthritis in rats. These results suggest that EA could serve as a potential new drug for the treatment of arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Plant Sciences
Mengjiali Wei, Jiayan Su, Qian Ma, Fang Zhang, Jing Wang, Liang Feng, Xiaobin Jia, Xiaobin Tan
Summary: Erteng Tongbi Decoction can significantly improve collagen-induced arthritis by modulating T cell differentiation and cytokines balance. It contains various active constituents.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Xingyue Zeng, Songsong Lu, Meng Li, Mohan Zheng, Tianci Liu, Rui Kang, Lijuan Xu, Qinzhu Xu, Ying Song, Chen Liu
Summary: This study found that follicular helper T cells and follicular regulatory T cells are increased and functionally enhanced in rheumatoid arthritis. After treatment with inflammatory factor-neutralizing antibodies, these cell subsets and functions return to normal.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bettina Sehnert, Sandy Pohle, Cornelia Heuberger, Rita Rzepka, Maximilian Seidl, Falk Nimmerjahn, Nina Chevalier, Jens Titze, Reinhard E. Voll
Summary: The study demonstrates that low salt diet can significantly decrease the severity of experimental arthritis, while high salt diet exacerbates inflammation. Additionally, low salt diet not only benefits humoral immunity but also helps regulate cellular immunity in experimental arthritis models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Fu-Tzu Pai, Cheng-You Lu, Chia-Hsin Lin, John Wang, Ming-Cheng Huang, Chuan-Teng Liu, Ying-Chyi Song, Cheng-Lung Ku, Hung-Rong Yen
Summary: The study demonstrated the potential antiarthritic effects of PCL by inhibiting inflammation and increasing MDSCs, suggesting that PCL may be a promising therapeutic herb for the treatment of rheumatoid arthritis.
Article
Engineering, Environmental
Simin Wang, Qixing Zhou, Yingze Tian, Xiangang Hu
Summary: This study demonstrates a close correlation between alterations in the pulmonary microbiota and pulmonary inflammation and oxidative stress caused by PM2.5 exposure. Transfer of the microbiota and antibiotic intervention can affect the severity of pulmonary inflammation and oxidative stress. These results reveal the important role of the pulmonary microbiota.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Biochemistry & Molecular Biology
Juan Liu, Yan Liu, Wenyou Pan, Yongsheng Li
Summary: The study investigated the anti-rheumatic effects of Ang-(1-7) in rat models with collagen-induced arthritis, finding that it improved arthritis symptoms by inhibiting oxidative stress, while Nox1 overexpression reversed this inhibitory effect.
Article
Biochemistry & Molecular Biology
Devin Amanda Simpkins, Polly Downton, Kathryn J. Gray, Suzanna H. Dickson, Robert J. Maidstone, Joanne E. Konkel, Matthew R. Hepworth, David W. Ray, David A. Bechtold, Julie Elizabeth Gibbs
Summary: The gut microbiota plays an important role in host health and immune system function. Rheumatoid arthritis, an autoimmune disease, is associated with imbalances in gut microbiota. The composition and metabolism of the microbiome exhibit daily oscillations, influenced by food intake timing and circadian clock function in the gut. Inflammatory arthritis leads to changes in circadian rhythmicity in the gut and microbiome, affecting gene expression, barrier integrity, and the composition of the microbiota. These findings highlight the impact of altered circadian rhythmicity on gut integrity and microbiome function during inflammatory diseases.
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bettina Sehnert, Veronica Valero-Esquitino, Georg Schett, Thomas Unger, Ulrike Muscha Steckelings, Reinhard Edmund Voll
Summary: The selective non-peptide AT(2)R agonist Compound 21 (C21) has therapeutic potential in collagen-induced arthritis by promoting the expansion of CD4(+) regulatory T cells and suppressing IL-17A production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rupali Choudhary, Diksha Saroch, Diljeet Kumar, Sobia Anjum, Nusrit Iqbal Andrabi, Tazeem Akram, Bhahwal Ali Shah, Sanket K. Shukla, Asha Bhagat, Gurleen Kour, Zabeer Ahmed
Summary: The study investigates the potential of combining BA-25 with the conventional drug MTX for its anti-inflammatory and anti-arthritic effects. The results demonstrate that the combination treatment effectively reduces inflammation and improves arthritis symptoms. Additionally, no significant toxic effects were observed in the mouse model with the combination therapy.