期刊
PHARMACOGNOSY MAGAZINE
卷 10, 期 37, 页码 S30-S36出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0973-1296.127337
关键词
Fritillaria thunbergii Miq.; Fourier transform infrared spectrometry; microwave digestion - ICP-AES; sulfur-fumigation
资金
- National Natural Science Foundation of China [81173546, 30940093, 81202918]
- Natural Science Foundation of Jiangsu Province, China [BK2009495]
- International Science and Technology Cooperation Project of Jiangsu Province, China [BZ2011053]
- Project of Science Technology Department of Zhejiang Province, China [2012D60SA1C0065, 2012D60SA1C0066]
- Open Project of National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine [2011ZYX2-001, 2011ZYX2-006]
- Chinese Medicine Research Program of Zhejiang Province, China [2008ZA002]
- Science Foundation of Zhejiang Chinese Medical University [2011ZY25, 7211093]
- Project of Science and Technology for Chinese Medicine of Zhejiang Province, China [2013KYB183]
- Project of Science Technology Department of Hangzhou, China [20130533B68]
- Fund of Zhejiang Modernization of Traditional Chinese Medicine Item [[2008]436, [2012]680]
Background: Sulfur-fumigation may induce chemical transformation of traditional Chinese medicines leading to harmful effects following patient ingestion. For quality control, it is urgently needed to develop a reliable and efficient method for sulfur-fumigation identification. Materials and Methods: The spectrochemical identification of non-fumigated and sulfur-fumigated Fritillaria thunbergii Miq. was carried out to evaluate inorganic elements and organic components. The concentrations of 12 elements, including Zn, Mn, Cu, Fe, Li, Mg, Sr, Pb, As, Cd, Hg, and S of samples were determined by microwave digestion-inductively coupled plasma atomic emission spectrometry (ICP-AES). Meanwhile, Fourier transform infrared spectrometry (FTIR) was used for the study of chemical group characteristic reactions after sulfur-fumigation. Results: The concentrations of Fe, Mg, Hg, and S elements showed significant differences between non-fumigated and sulfur-fumigated Fritillaria thunbergii Miq. The characteristic stretching vibrations of some groups in FTIR spectra, such as-OH,-S = O and-S-O, provided the identification basis for the discrimination of non-fumigated and sulfur-fumigated Fritillaria thunbergii Miq. Conclusion: The application of microwave digestion-ICP-AES was successfully used in combination with FTIR to authenticate and evaluate the quality of medicinal Fritillaria thunbergii Miq. Further applications of this technique should be explored.
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