Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Oncology
Duanyang Zhai, Tianfu Li, Runyi Ye, Jiong Bi, Xiaying Kuang, Yawei Shi, Nan Shao, Ying Lin
Summary: This study identified that the lncRNA LGALS8-AS1 is highly expressed in breast cancer and promotes the metastasis of breast cancer cells. LGALS8-AS1 upregulates SOX12 by sponging miR-125b-5p, thus activating the PI3K/AKT signaling pathway to facilitate breast cancer metastasis. The reciprocal regulatory loop of LGALS8-AS1/miR-125b-5p/SOX12 may serve as a potential therapeutic target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Genetics & Heredity
Liudmila V. Spirina, Irina V. Kovaleva, Svetlana Yu. Chizhevskaya, Anastasiya V. Chebodaeva, Nataliya V. Tarasenko
Summary: This study investigated the role of autophagy related genes and proteins in thyroid cancer through bioinformatics analysis and tissue sample detection. The results showed that miR-125b is involved in the regulation of autophagy and its expression is reduced in thyroid cancer patients compared to benign tumor patients. BRAFV600E mutations were associated with decreased hsa-miR-125b expression. The study suggests that autophagy related proteins play a significant role in cancer progression and non-coding RNA sequences are implicated in oncogenic processes. miR-125b may serve as a potential marker for thyroid cancer invasion, BRAV600E mutational status, and risk of recurrence.
Article
Biochemistry & Molecular Biology
Dong Suwei, Xiao Yanbin, Wang Jianqiang, Ma Xiang, Peng Zhuohui, Kang Jianping, Wang Yunqing, Li Zhen
Summary: The study reveals that the miR-5100/SPINK5/STAT3 axis promotes melanoma cell metastasis, while metformin can significantly inhibit this pathway and prevent melanoma metastasis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Oncology
Beatriz Sanchez-Sendra, Jose F. Gonzalez-Munoz, Silvia Perez-Deben, Carlos Monteagudo
Summary: This study found that BRAF mutations do not significantly affect the predictive ability of miR-125b, miR-200c, and miR-205. These three miRNAs can independently predict the clinical outcomes of patients with primary melanoma, regardless of BRAF mutational status.
Article
Cell Biology
Feng Ying Zhang, Xia Li, Ting Ting Huang, Mei Ling Xiang, Lin Lin Sun, Zhao Lan Sun
Summary: LINC00839 is highly expressed in nasopharyngeal carcinoma (NPC), and its attenuation can reduce the aggressive properties of NPC cells by directly sponging miR-454-3p and regulating c-Met expression.
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Article
Medicine, Research & Experimental
Yan Li, Juan Wang, Wenyu Chen, Xiaoping Chen, Jianhua Wang
Summary: This study revealed the crucial role of STAT4 in the metastasis and invasion of ovarian cancer, especially under hypoxic conditions. MiR-200a was identified as a direct regulator of STAT4, influencing the progression of EMT in ovarian cancer cells. These findings suggest a potential therapeutic target for the treatment of ovarian cancer.
Article
Oncology
Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma, Jinlong Wang
Summary: This study revealed that miR-106b-5p levels are elevated in melanoma tissues, and high expression of miR-106b-5p is an independent risk factor for overall survival in melanoma patients. Exosomal miR-106b-5p promotes melanocyte migration, invasion and metastasis by targeting EphA4 to activate the ERK pathway.Overall, melanoma cell-secreted exosomal miR-106b-5p could potentially serve as a diagnostic indicator and therapeutic target for melanoma patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marta Arumi-Planas, Francisco Javier Rodriguez-Baena, Francisco Cabello-Torres, Francisco Gracia, Cristina Lopez-Blau, M. Angela Nieto, Berta Sanchez-Laorden
Summary: Melanoma is a highly metastatic and therapy-resistant form of skin cancer. The tumour microenvironment, particularly fibroblasts, plays a crucial role in melanoma progression. This study reveals that Snail1, a transcription factor involved in epithelial-to-mesenchymal transition, is activated in the melanoma microenvironment. Targeting Snail1 in the tumour microenvironment decreases melanoma growth and lung metastatic burden, extending survival. Snail1 promotes melanoma growth by inducing an immunosuppressive microenvironment and reducing anti-tumour immunity.
Article
Oncology
Xiang Long, Ding-Guo Wang, Zhi-Bo Wu, Zhong-Min Liao, Jian-Jun Xu
Summary: This study investigated the potential role of SWT1-derived circRNAs in non-small-cell lung cancer (NSCLC) and found that circSWT1 promoted the invasion, migration, and epithelial-mesenchymal transition (EMT) of NSCLC. These findings suggest that circSWT1 could serve as a potential biomarker and therapeutic target for NSCLC.
Article
Cell Biology
Yang-Zhi Hu, Zhi-Li Hu, Tian-You Liao, Yuan Li, Yun-Long Pan
Summary: This study aimed to investigate the effects of lncRNA SND1-IT1, miR-124, and COL4A1 gene on TGF-beta 1-induced EMT in gastric cancer (GC). Through the analysis of tissue samples and experiments on HGC-27 cells, the results demonstrated that TGF-beta 1 can regulate cancer cell migration, invasion, and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Shiqi Jin, Yu Song, Li Zhou, Wei Jiang, Liping Qin, Yufeng Wang, Ruiqi Yu, Yuting Liu, Yujie Diao, Fan Zhang, Kaixuan Liu, Peishan Li, Huili Hu, Baichun Jiang, Wei Tang, Fan Yi, Yaoqin Gong, Guangyi Liu, Gongping Sun
Summary: Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease, and macrophage infiltration plays a critical role in its progression. This study reveals that myeloid deficiency of CUL4B alleviates diabetes-induced renal injury and fibrosis. The mechanism involves the CUL4B/miR-194-5p/ITGA9 axis, where CUL4B promotes migration and adhesion of macrophages by repressing miR-194-5p expression and increasing ITGA9 levels.
Article
Biochemistry & Molecular Biology
Dan-Feng Xue, Shu-Ting Pan, Gan Huang, Jia-Xuan Qiu
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Qingkun Jiang, Danfeng Xue, Yuqi Xin, Jiaxuan Qiu
Summary: This study aimed to develop and validate a competing risk nomogram for predicting cancer-specific death in buccal mucosa cancer (BMC) patients. By analyzing patient data, independent risk factors associated with cancer-specific death were identified, leading to the development of a prognostic nomogram with good prediction performance.
Article
Dentistry, Oral Surgery & Medicine
Wei He, Hai Zhang, Jiaxuan Qiu
Summary: This study demonstrated that pure magnesium induces rapid osteogenesis in rat mandibular alveolar bone, especially in the subperiosteal region. In vitro, higher magnesium ion concentrations enhance the osteogenic capacity of periosteum-derived cells (PDCs).
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Oncology
Fanzhe Shi, Danfeng Xue, Qingkun Jiang, Jiaxuan Qiu
Summary: The study demonstrated that GLA inhibits cell viability and growth in TSCC cells by inducing apoptosis and autophagy through ROS production, suggesting its potential therapeutic use in overcoming TSCC.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Oncology
Qun Zhou, Fangfei Ye, Jiaxuan Qiu, Siying Zhang, Qingkun Jiang, Danfeng Xue, Jialun Li
Summary: This study found that Dihydroartemisinin can inhibit the proliferation of tongue squamous cell carcinoma cells and induce apoptosis, as well as stimulate the production of reactive oxygen species and activate endoplasmic reticulum stress. However, the use of a reactive oxygen species inhibitor can alleviate the endoplasmic reticulum stress and apoptosis induced by Dihydroartemisinin.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kairui Chen, Chunyuan Luo, Jiaxuan Qiu, Qiang Zhang
Summary: This article reports a case of glandular odontogenic cyst (GOC) associated with odontoma, deepening the understanding of this rare jawbone cyst through diagnostic imaging and histopathological features.
JOURNAL OF MAXILLOFACIAL & ORAL SURGERY
(2022)
Article
Pharmacology & Pharmacy
Danfeng Xue, Xiongming Zhou, Jiaxuan Qiu
Summary: The study found that plumbagin has a greater inhibitory effect on drug-resistant cells compared to sensitive cells, inducing apoptosis and protective autophagy in TSCC cells. Mechanistically, plumbagin induces apoptosis and autophagy by generating reactive oxygen species to mediate JNK and AKT/mTOR pathways, and its growth inhibitory effect against drug-resistant TSCC was confirmed in vivo.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Oncology
Qingkun Jiang, Danfeng Xue, Fanzhe Shi, Jiaxuan Qiu
Summary: By analyzing gene sequencing and clinicopathological data, this study identified autophagy-related lncRNAs in patients with OSCC/OPSCC and established a signature that can serve as an independent prognostic indicator, promoting research on targeted diagnosis and treatment for these patients.