CYP2D6 and the severity of suicide attempts

Aim: Among people who die by suicide, an increased frequency of CYP2D6 active gene multiplication has been described. Therefore, the present study analyzed the relationship between the severity of the suicidal intent and CYP2D6 number of active genes among survivors. Materials & methods: A group of 342 individuals were evaluated with Beck Suicide Intent Scale within 24 h of the failed attempt. 'Severe' suicide attempters were classified as those scoring above percentile 75 in the objective circumstances section of the Suicide Intent Scale Scale. A group of 377 healthy controls were also genotyped. Results: A higher number of 'severe' suicide attempters carrying >= 2 active CYP2D6 genes as compared with the rest of the patients population (p < 0.01) or the healthy control group (p < 0.01) was found. Conclusion: Considering that 'severe' suicide attempters are more likely eventually to die by suicide, CYP2D6 genetic polymorphism might be of use as a biomarker of death by suicide, which is in agreement with previous findings. Original submitted: 17 July 2011; Revision submitted: 21 September 2011