Article
Multidisciplinary Sciences
Maarten Bak, Marjan Drukker, Shauna Cortenraad, Emma Vandenberk, Sinan Guloksuz
Summary: This meta-analysis found that antipsychotics are associated with body weight gain, regardless of psychiatric diagnosis.
Review
Psychiatry
Zeeshan Mansuri, Ramkrishna Makani, Chintan Trivedi, Mahwish Adnan, Ramu Vadukapuram, John Rafael, Ashutosh Lodhi, Abhishek Reddy
Summary: Metformin may have beneficial effects in treating weight gain in children treated with second-generation antipsychotics, with significant reductions in weight and BMI Z-score observed within 12-16 weeks. However, the use of metformin may increase the likelihood of nausea-vomiting and diarrhea as side effects.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Yiwen Zhu, Franca Centorrino, John W. Jackson, Garrett M. Fitzmaurice, Linda Valeri
Summary: The study utilized meta-analytic causal mediation analysis to combine evidence from multiple studies and enhance statistical power. Results indicate that positive symptoms play a significant mediating role in the treatment effect of negative symptoms, while weight gain may have beneficial mediating effects but could diminish at high doses with excessive metabolic side effects.
Article
Psychiatry
Maria S. Neumeier, Stephanie Homan, Stefan Vetter, Erich Seifritz, John M. Kane, Maximilian Huhn, Stefan Leucht, Philipp Homan
Summary: The variability in side effects of antipsychotic drugs is significant in the treatment of schizophrenia spectrum disorders, potentially leading to treatment nonadherence among patients. Research indicates marked differences in side effects among individual antipsychotic drugs, suggesting that personalized or stratified medicine allocation may benefit certain patient subgroups or individuals.
SCHIZOPHRENIA BULLETIN
(2021)
Review
Psychology, Multidisciplinary
Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, Maria J. Arranz, Rosa Catalan, Gesche Jurgens, Sanne Maartje Kloosterboer, Henrik Berg Rasmussen, Anjali Bhat, Haritz Irizar, Dora Koller, Renato Polimanti, Baihan Wang, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Elvira Bramon
Summary: The CYP2D6 genetic variation may influence weight gain in individuals taking antipsychotic medications, but further large-scale studies are needed to confirm the association.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Alqassem Y. Hakami, Razaz Felemban, Rami Ghazi Ahmad, Abdulrahman H. Al-Samadani, Hassan K. Salamatullah, Jamil M. Baljoon, Loay J. Alghamdi, Mostafa H. Ramadani Sindi, Mohamed Eldigire Ahmed
Summary: This study investigated the impact of antipsychotics use on weight gain and found that the concomitant use of metformin may significantly reduce the occurrence of AIWG.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Diana Z. Paderina, Anastasiia S. Boiko, Ivan V. Pozhidaev, Anna V. Bocharova, Irina A. Mednova, Olga Yu. Fedorenko, Elena G. Kornetova, Anton J. M. Loonen, Arkadiy V. Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study investigated the association of nine polymorphisms in serotonergic system genes with MetS in patients with schizophrenia. Results suggested that allelic variants of HTR2C genes may affect metabolic parameters, and MetS is too complex to be studied without dissecting it into individual components.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Psychiatry
Ita Fitzgerald, Laura J. Sahm, Amy Byrne, Jean O'Connell, Joie Ensor, Ciara Ni Dhubhlaing, Sarah O'Dwyer, Erin K. Crowley
Summary: This study systematically explored the impact of non-genetic prognostic factors on the variable prognosis of antipsychotic-induced weight gain (AIWG). The results showed that age, baseline BMI, and sex had nonsignificant effects on AIWG prognosis. However, the trend of early BMI increase was identified as the most clinically significant prognostic factor, which should be included in AIWG management guidance.
EUROPEAN PSYCHIATRY
(2023)
Review
Nutrition & Dietetics
Qiqi Ren, Kaifeng Li, Han Sun, Chengdong Zheng, Yalin Zhou, Ying Lyu, Wanyun Ye, Hanxu Shi, Wei Zhang, Yajun Xu, Shilong Jiang
Summary: The study found that there was no significant difference in growth between formula-fed and breastfed infants in the early stages of life. However, infants consuming formula with higher protein content grew faster at 2-3 months old. Furthermore, formula-fed infants showed faster growth compared to breastfed infants as time progressed.
Review
Endocrinology & Metabolism
Helene Speyer, Casper Westergaard, Nikolai Albert, Mette Karlsen, Anne Emilie Sturup, Merete Nordentoft, Jesper Krogh
Summary: The study found that reducing dosage, discontinuing medication, or switching to a partial agonist can lead to a small but significant weight loss of around 1.5 kg. The overall weight change from pre to post intervention was a reduction of 1.13 kg.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Manit Srisurapanont, Sirijit Suttajit, Surinporn Likhitsathian, Benchalak Maneeton, Narong Maneeton
Summary: This study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine, finding no significant differences in weight changes and all-cause dropout rates between the two treatments.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Christine N. Huynh, Janina Pearce, Le Kang, Francesco S. Celi
Summary: A systematic review and meta-analysis found that patients undergoing thyroidectomy may experience mild weight gain post-surgery, especially in younger individuals and those with hyperthyroidism as the indication for surgery. Studies on weight gain post-thyroidectomy pathophysiology and treatment modalities are warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Albert Martinez-Pinteno, Patricia Gasso, Llucia Prohens, Alex G. Segura, Mara Parellada, Jeronimo Saiz-Ruiz, Manuel J. Cuesta, Miguel Bernardo, Amalia Lafuente, Sergi Mas, Natalia Rodriguez
Summary: This study identified EP300 as a key gene involved in the metabolic abnormalities induced by antipsychotic drugs. Modulating EP300 levels may be beneficial in mitigating treatment side effects. However, further research is needed to determine the exact role of this gene in the mechanism of action of medications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Psychiatry
Stefan Leucht, Johannes Schneider-Thoma, Angelika Burschinski, Natalie Peter, Dongfang Wang, Shimeng Dong, Maximilian Huhn, Adriani Nikolakopoulou, Georgia Salanti, John M. Davis
Summary: Using network meta-analysis, we examined the long-term efficacy of antipsychotic drugs in acutely ill patients with schizophrenia. Olanzapine was found to be more efficacious than several other antipsychotic drugs in terms of overall symptoms. However, its impact on weight gain was higher compared to other antipsychotics. These findings highlight the need to consider the efficacy and side effect profile of olanzapine in clinical decision-making.
Review
Nutrition & Dietetics
Edmund Przegalinski, Kacper Witek, Karolina Wydra, Jolanta H. Kotlinska, Malgorzata Filip
Summary: Obesity is a significant health and economic issue, and the serotonin system, specifically the 5-HT2C receptors, plays a crucial role in regulating body weight. This review focuses on the use of 5-HT2C receptor agonists as antiobesity medications, such as fenfluramines, sibutramine, and lorcaserin, and discusses the potential of 5-HT2C receptor positive allosteric modulators as safer alternatives. More research is needed to determine the efficacy of these drugs in obesity prevention and treatment.
Article
Psychology, Clinical
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N. Frey, Faranak Farzan, Pierre Blier, Jane A. Foster, Sagar Parikh, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Gustavo Turecki, Valerie H. Taylor, Raymond W. Lam, Stephen C. Strother, Sidney H. Kennedy
Summary: Predicting treatment outcomes for major depressive disorder can be improved by combining clinical, neuroimaging, and molecular data. Early measurement during treatment can increase precision, but adding more features does not necessarily enhance prediction accuracy.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Rayyan Zuberi, Roseann S. Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Muller
Summary: In this study, the association between six ABCB1 single-nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes was investigated through a systematic review and meta-analysis. No significant association was found between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. However, a significant association between rs1128503 and treatment response was observed in the meta-analysis. These findings provide limited evidence for the implementation of ABCB1 genotyping to inform antidepressant treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Lindsay M. Melhuish Beaupre, Michael Wainberg, Clement C. Zai, Milos Milic, Daniel Felsky, Gregory Brown, Benjamin Goldstein, Shreejoy J. Tripathy, James L. Kennedy, Vanessa F. Goncalves
Summary: This study conducted genome-wide association studies on UK Biobank participants and found a bidirectional relationship between sleep disturbances and depression, as well as the involvement of mitochondria in sleep biology. The results suggest that common genetic variations and mitochondria may play a role in sleep characteristics among depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Xinyue Jiang, Alysha A. Sultan, Mikaela K. Dimick, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh, Benjamin Goldstein
Summary: This study found that the CACNA1C rs1006737 A allele is associated with resting-state functional connectivity (rsFC) in youth with bipolar disorder (BD) in regions relevant to emotion, executive function, and reward. Future task-based approaches are necessary to further understand the brain connectivity related to CACNA1C in BD.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Immunology
Debmalya Barh, Flavia Figueira Aburjaile, Thais Silva Tavares, Miguel Etcheverria da Silva, Gabriel Pissolati Mattos Bretz, Igor Fernando Martins Rocha, Annesha Dey, Renan Pedra de Souza, Aristoteles Goes-Neto, Servio Pontes Ribeiro, Khalid J. Alzahrani, Ahmad A. Alghamdi, Fuad M. Alzahrani, Ibrahim Faisal Halawani, Sandeep Tiwari, Alaa A. A. Aljabali, Kenneth Lundstrom, Vasco Azevedo, Nirmal Kumar Ganguly
Summary: In this study, a nutrigenomics approach was applied to investigate the association between dietary habits and COVID-19 severity and deaths. The results showed that distinct dietary habits of Indians, including increased consumption of certain food components and regular consumption of tea and turmeric, may contribute to the lower death rate from COVID-19 compared to western populations. These food components were found to suppress cytokine storm and various severity-related pathways of COVID-19.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Roberta Rayra Martins-Chaves, Marina Goncalves Diniz, Lucyene Miguita, Fernanda Aragao Felix, Fernanda Faria Rocha, Paula Luize Camargos Fonseca, Victor Emmanuel Viana Geddes, Diego Menezes, Rennan Garcias Moreira, Tatiana Liborio-Kimura, Jeconias Camara, Tassia Caroline da Costa Mendes, Helder Antonio Rebelo Pontes, Flavia Sirotheau Correa Pontes, Thayanne Oliveira de Freitas Goncalves, Thamyres Campos Fonseca, Aline Correa Abrahao, Mario Jose Romanach, Ana Paula Negreiros Nunes Alves, Karuza Maria Alves Pereira, Danyel Elias da Cruz Perez, Elaine Judite de Amorim Carvalho, Jean Nunes dos Santos, Flavia Calo de Aquino Xavier, Fernando Costa Giffoni, Alessandra Hubner de Souza, Carolina Cavalieri Gomes, Silvia Ferreira de Sousa, Felipe Paiva Fonseca, Renan Pedra de Souza, Renato Santana Aguiar, Ricardo Santiago Gomez
Summary: The omissions of the Brazilian Federal government in managing the COVID-19 crisis and their anti-science stance have caused severe consequences. The lack of mass-testing programs resulted in the rapid spread of SARS-CoV-2 throughout the Brazilian population. A study found that SARS-CoV-2 infection can be successfully identified through testing of oral tissue samples, suggesting its use for further research on SARS-CoV-2 patients and cautioning against using oral tissue samples as a tool for asymptomatic epidemiological surveillance.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Clinical Neurology
Parnian Puramat, Mikaela K. Dimick, Kody G. Kennedy, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh, Benjamin Goldstein
Summary: This study found that the APOE epsilon 4 gene is associated with neurostructural differences in individuals with bipolar disorder (BD) and controls, but the regional differences in neurostructures between the two groups were significant. This suggests that APOE epsilon 4 may have important implications for neurodevelopmental processes.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Kazunari Yoshida, Victoria S. Marshe, Samar S. M. Elsheikh, Malgorzata Maciukiewicz, Arun K. Tiwari, Eva J. Brandl, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Mueller
Summary: This study investigated the association between polygenic risk scores (PRS) for various psychiatric and metabolic traits and antipsychotic-induced weight gain (AIWG). The results showed nominal associations between PRSs for BMI, CAD, LDL-C, type 1 diabetes, and SCZ with AIWG. Although these associations became non-significant after multiple testing correction, these preliminary findings suggest that PRS analyses may help identify risk factors for AIWG and elucidate the underlying mechanisms.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Virology
Joice do Prado Silva, Aline Brito de Lima, Luige Biciati Alvim, Frederico Scott Varella Malta, Cristiane Pinheiro Toscano Brito Mendonca, Andre Henrique Barbosa de Carvalho, Jessica Silqueira Hickson Rios, Paula Luize Camargos Fonseca, Daniel Costa Queiroz, Luiza Campos Guerra de Araujo e Santos, Alessandro Clayton de Souza Ferreira, Renan Pedra de Souza, Renato Santana de Aguiar, Danielle Alves Gomes Zauli
Summary: The introduction of SARS-CoV-2 variants of concern (VOCs) in Brazil had significant impacts on the epidemiological and public health scenario. This study investigated the frequency, introduction, and dispersion of SARS-CoV-2 variants in 12 Brazilian capitals. Analysis showed that Omicron VOC replaced Delta VOC within approximately 3.5 weeks and had a lower viral load in infected patients. Clinical outcome analysis indicated that individuals infected with Omicron were less likely to require ventilatory support. These findings emphasize the importance of national surveillance programs and the faster spread of Omicron over Delta VOC in Brazil.
Article
Pharmacology & Pharmacy
Amanda Fonseca Medeiros, Caryne Margotto Bertollo, Adriano Max Moreira Reis, Monica Aparecida Costa, Edna Marilea Meireles Leite, Simony da Silva Goncalves, Mauro Henrique Nogueira Guimaraes de Abreu, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins
Summary: Antimicrobial resistance (AMR) is a major global challenge that is increasing and has negative impacts on morbidity, mortality, hospital stays and costs. Antimicrobial Stewardship Programs (ASP) are essential in promoting the rational use of antimicrobials, as AMR is mainly driven by their consumption.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Joao Locke Ferreira de Araujo, Victoria Frigerio Bonifacio, Lorena Medeiros Batista, Renata Eliane de avila, Renato Santana Aguiar, Luciana Bastos-Rodrigues, Renan Pedra de Souza
Summary: In this study involving 102 hospitalized Brazilian COVID-19 patients, three polymorphisms at the 3p21.31 locus (LZTFL1 rs10490770, CXCR6 rs2234355, and rs2234358) were found to be not associated with the need for mechanical ventilation and hospitalization length. However, the CXCR6 rs2234355 was found to be associated with mortality in the codominance model, with individuals carrying the A/A genotype having a higher risk of death compared to those carrying the A/G genotype.
CURRENT MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Emilio Itamar de Freitas Campos, Karina Braga Gomes, Daniel Dias Ribeiro, Marja Kaarina Puurunen, Aline deOliveira Magalhaes Mourao, Isadora Goncalves Ferreira, Manoel Otavio da Costa Rocha, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins
Summary: This study investigated the impact of polymorphisms in CYP2C9, VKORC1, MDR1, and APOE genes on the mean weekly warfarin maintenance dose in adults. The results showed that age, use of amiodarone, and specific genotypes were associated with a reduced warfarin dose.
Article
Psychiatry
Xinyue Jiang, Clement C. Zai, Kody G. Kennedy, Yi Zou, Yuliya S. Nikolova, Daniel Felsky, L. Trevor Young, Bradley J. Macintosh, Benjamin I. Goldstein
Summary: This study found a negative association between a polygenic risk score for bipolar disorder (BD-PRS) based on adult genetic data and grey matter structure and white matter integrity in youth. These findings may provide clues for identifying neuroimaging markers of bipolar disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Martin Zack, Daniela Lobo, Candice Biback, Tim Fang, Kelly Smart, Daniel Tatone, Aditi Kalia, Daniel Digiacomo, James L. Kennedy
Summary: This study aimed to investigate the effects of gambling-specific priming manipulations and the pharmacological basis on risk-taking in a Game of Dice Task (GDT). The results showed that both gambling and AMPH increased risk-taking, with a stronger effect observed in individuals with gambling disorder. The outcomes varied with pre-treatment, and cognitive inflexibility and symptom severity moderated the effects.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Xinyue Jiang, Clement C. Zai, Alysha A. Sultan, Mikaela K. Dimick, Yuliya S. Nikolova, Daniel Felsky, Bradley J. Macintosh, Benjamin I. Goldstein
Summary: This study found an association between BD-PRS based on adult genetic data and altered rsFC patterns of brain networks in youth. The use of BD-PRS in investigating genetically influenced neuroimaging markers of vulnerability to BD is supported, as these markers can be observed in youth with BD early in their illness and in healthy youth.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
