☆ 4.2 Article

CYP3A5 and ABCB1 genes and hypertension

PHARMACOGENOMICS (2009)

期刊

PHARMACOGENOMICS

卷 10, 期 3, 页码 477-487

出版社

FUTURE MEDICINE LTD

DOI: 10.2217/14622416.10.3.477

关键词

ABCB1; blood pressure; CYP3A5; dietary salt intake; gene-gene interaction; hypertension; renin-angiotensin system

类别

Pharmacology & Pharmacy

资金

Swiss National Foundation for Science [3200BO-111362/1, 3233BO-111361/1]

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Reagent

摘要

Hypertension is the first single modifiable cause of disease burden worldwide. Genes encoding proteins that are involved in the metabolism (CYP3A5) and transport (ABCB1) of drugs and hormones might contribute to blood pressure control in humans. Indeed, recent data have suggested that CYP3A5 and ABCB1 gene polymorphisms are associated with blood pressure in the rat as well as in humans. Interestingly, the effects of these genes on blood pressure appear to be modified by dietary salt intake. This review summarizes what is known regarding the relationships of the ABCB1 and CYP3A5 genes with blood pressure, and discusses the potential underlying mechanisms of the association. if the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans.

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Lotufo, Jose Eugenio Lozano, Iva Lukacevic Lovrencic, Janice L. Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Michala Lustigova, Edyta Luszczki, Guansheng Ma, Jun Ma, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Enguerran Macia, Luisa M. Macieira, Ahmed A. Madar, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna, Sofia K. Malyutina, Lynell V. Maniego, Yannis Manios, Jim I. Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Anie Marcil, Paula Margozzini, Staffan B. Marild, Mihalea Marinovic Glavic, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Luis P. Mascarenhas, Marija Matasin, Ellisiv B. Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matlosz, Tandi E. Matsha, Christina Mavrogianni, Jean Claude N. Mbanya, Anselmo J. Mc Donald Posso, Shelly R. McFarlane, Stephen T. McGarvey, Stela McLachlan, Rachael M. McLean, Scott B. McLean, Breige A. McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Christa Meisinger, Carlos Mendoza Montano, Ana Maria B. Menezes, Geetha R. Menon, Alibek Mereke, Indrapal I. Meshram, Andres Metspalu, Haakon E. Meyer, Jie Mi, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C. Miller, Claudia S. Minderico, G. K. Mini, J. Jaime Miranda, Mohammad Reza Mirjalili, Erkin Mirrakhimov, Marjeta Misigoj-Durakovic, Pietro A. Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K. Mohamed, Shukri F. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T. Mollehave, Denes Molnar, Amirabbas Momenan, Charles K. Mondo, Eric Monterrubio-Flores, Kotsedi Daniel K. Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos Andre Moura-dos-Santos, Malay K. Mridha, Kelias P. Msyamboza, Thet Thet Mu, Alfa J. Muhihi, Maria L. Muiesan, Martina Muller-Nurasyid, Neil Murphy, Jaakko Mursu, Kamarul Imran Musa, Sanja Music Milanovic, Vera Musil, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M. Naidu, Farid Najafi, Harunobu Nakamura, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Sameer Narake, Ndeye Coumba Ndiaye, William A. Neal, Azim Nejatizadeh, Ilona Nenko, Martin Neovius, Hannelore K. Neuhauser, Chung T. Nguyen, Nguyen D. Nguyen, Quang V. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martinez, Teemu J. Niiranen, Yury P. Nikitin, Toshiharu Ninomiya, Sania Nishtar, Marina A. Njelekela, Marianna Noale, Oscar A. Noboa, Ahmad Ali Noorbala, Teresa Norat, Maria Nordendahl, Borge G. Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Baltazar Nunes, Terence W. O'Neill, Dermot O'Reilly, Caleb Ochimana, Eiji Oda, Augustine N. Odili, Kyungwon Oh, Kumiko Ohara, Ryutaro Ohtsuka, Valerie Olie, Maria Teresa A. Olinto, Isabel O. Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M. Ono, Pedro Ordunez, Rui Ornelas, Pedro J. Ortiz, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Karina Mary de Paiva, Andrzej Pajak, Domenico Palli, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Dimitrios Papandreou, Soon-Woo Park, Suyeon Park, Winsome R. Parnell, Mahboubeh Parsaeian, Patrick Pasquet, Nikhil D. Patel, Halyna Pavlyshyn, Ivan Pecin, Mangesh S. Pednekar, Joao M. Pedro, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Karen G. D. A. Peres, Marco A. Peres, Annette Peters, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Rafael N. Pichardo, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubio, Ozren Polasek, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J. Price, Jacqueline F. Price, Rui Providencia, Soile E. Puhakka, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Daniel Queiroz, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Ellina M. Rakhimova, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A. Rangel Reina, Vayia Rarra, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M. Reganit, Valeria Regecova, Luis Revilla, Abbas Rezaianzadeh, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Tobias F. Rinke de Wit, Raphael M. Ritti-Dias, Cynthia Robitaille, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Ulla Roggenbuck, Rosalba Rojas-Martinez, Dora Romaguera, Elisabetta L. Romeo, Annika Rosengren, Joel G. R. Roy, Adolfo Rubinstein, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Iuliia A. Rusakova, Paola Russo, Marcin Rutkowski, Charumathi Sabanayagam, Hamideh Sabbaghi, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Olfa Saidi, Sibel Sakarya, Nader Saki, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmeron, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Susana Sans, Diana A. Santos, Ina S. Santos, Lelita C. Santos, Maria Paula Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Giselle Sarganas, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Herman Schargrodsky, Sabine Schipf, Carsten O. Schmidt, Peter Schnohr, Ben Schoettker, Sara Schramm, Constance Schultsz, Aletta E. Schutte, Sylvain Sebert, Aye Aye Sein, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Jennifer Servais, Svetlana A. Shalnova, Teresa Shamah-Levy, Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K. Sharma, Jonathan E. Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Majid Shirani, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Caroline Ramos de Moura Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjostrom, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Eugene Sobngwi, Stefan Soderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Thorkild I. A. Sorensen, Elin P. Sorgjerd, Maroje Soric, Charles Sossa Jerome, Aicha Soumare, Bente Sparboe-Nilsen, Karen Sparrenberger, Jan A. Staessen, Gregor Starc, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stoeckl, Tanja Stocks, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Machi Suka, Chien-An Sun, Johan Sundstrom, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G. Sy, Holly E. Syddall, Rene Charles Sylva, Moyses Szklo, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Julie Taylor, William R. Tebar, Grethe S. Tell, Tania Tello, Yih Chung Tham, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Mikael Thinggaard, Nihal Thomas, Barbara Thorand, Betina H. Thuesen, Erik J. Timmermans, Dwi H. Tjandrarini, Anne Tjonneland, Ulla Toft, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topor-Madry, Maria Jose Tormo, Michael J. Tornaritis, Maties Torrent, Laura Torres-Collado, Giota Touloumi, Pierre Traissac, Areti Triantafyllou, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Lechaba Tshepo, Shoichiro Tsugane, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Gilad Twig, Per Tynelius, Christophe Tzourio, Peter Ueda, Eunice Ugel, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Rob M. van Dam, Bert-Jan van den Born, Johan Van der Heyden, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Elisabeth M. van Zutphen, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Senthil K. Vasan, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Giovanni Veronesi, W. M. Monique Verschuren, Roosmarijn Verstraeten, Cesar G. Victora, Lucie Viet, Salvador Villalpando, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Ari Voutilainen, Alisha N. Wade, Janette Walton, Elvis O. A. Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Junior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Nicholas Wareham, Wenbin Wei, Aneta Weres, Bo Werner, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Rainford J. Wilks, Johann Willeit, Peter Willeit, Emmanuel A. Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A. Wong-McClure, Andrew Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Shouling Wu, Justyna Wyszynska, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Tabara Yasuharu, Xingwang Ye, Panayiotis K. Yiallouros, Moein Yoosefi, Akihiro Yoshihara, San-Lin You, Novie O. Younger-Coleman, Ahmad Faudzi Yusoff, Ahmad A. Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Maria Elisa Zapata, Ko Ko Zaw, Tomasz Zdrojewski, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Shiqi Zhen, Yingfeng Zheng, Bekbolat Zholdin, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Nada Zoghlami, Julio Zuniga Cisneros

Summary: Global prevalence of hypertension doubled from 1990 to 2019, with significant improvements in detection, treatment, and control rates. In 2019, 59% of women and 49% of men with hypertension were previously diagnosed, while treatment rates were 47% for women and 38% for men, with control rates at 23% for women and 18% for men. Disparities exist across countries, with some middle-income nations now outperforming high-income countries in hypertension management.

LANCET (2021)

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Article Multidisciplinary Sciences

Gut microbiota alterations in response to sleep length among African-origin adults

Na Fei, Candice Choo-Kang, Sirimon Reutrakul, Stephanie J. Crowley, Dale Rae, Kweku Bedu-Addo, Jacob Plange-Rhule, Terrence E. Forrester, Estelle Lambert, Pascal Bovet, Walter Riesen, Wolfgang Korte, Amy Luke, Brian T. Layden, Jack A. Gilbert, Lara R. Dugas

Summary: Sleep duration was found to be associated with changes in gut microbiota composition, with shorter and longer sleepers showing higher levels of certain taxonomic features. These findings suggest a potential link between disrupted sleep patterns and gut microbiota composition, which may have implications for chronic inflammation associated diseases. Further research is needed to confirm these results and explore the underlying mechanisms.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Daily energy expenditure through the human life course

Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. Camps, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Teresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman

Summary: Total daily energy expenditure increases with fat-free mass in a power-law manner, showing four distinct life stages. The expenditure remains stable in adulthood (20 to 60 years), even during pregnancy, but declines in older adults.

SCIENCE (2021)

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Article Medicine, General & Internal

Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs

Lili Yang, Huan Wang, Liu Yang, Min Zhao, Yajun Guo, Pascal Bovet, Bo Xi

Summary: This study used a large birth cohort in the USA to investigate the associations between maternal cigarette smoking and various subtypes of birth congenital anomalies. The results showed that smoking before or during pregnancy significantly increased the risk of several congenital anomalies, even with low cigarette consumption. Smoking cessation during pregnancy did not reduce the risk of birth congenital anomalies. These findings highlight the importance of implementing smoking cessation interventions before pregnancy.

BMC MEDICINE (2022)

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Article Pediatrics

Psychotropic Drug Prescription in Children and Adolescents: Approved Medications in European Countries and the United States

Michal Smogur, Alice Onesanu, Kerstin Jessica Plessen, Chin B. Eap, Nicolas Ansermot

Summary: This article provides a synthesis of approved psychotropic drugs for children and adolescents in selected countries, aiming to assist prescribers in making appropriate medication choices.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2022)

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Article Environmental Sciences

Association between short-term exposure to ambient PM1 and PM2.5 and forced vital capacity in Chinese children and adolescents

Han Wu, Yingxiu Zhang, Jing Wei, Pascal Bovet, Min Zhao, Wenhui Liu, Bo Xi

Summary: This study examines the association between short-term exposure to ambient PM1, PM1-2.5, and PM2.5 and forced vital capacity (FVC). The results show that exposure to PM1 and PM2.5 is associated with decreased FVC.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Psychiatry

CYP2C19 expression modulates affective functioning and hippocampal subiculum volume-a large single-center community-dwelling cohort study

Claire Grosu, Olga Trofimova, Mehdi Gholam-Rezaee, Marie-Pierre F. Strippoli, Ferath Kherif, Antoine Lutti, Martin Preisig, Bogdan Draganski, Chin B. Eap

Summary: This study provides evidence of an association between mood phenotype and CYP2C19 genotype, showing that poor metabolizers have better mood status and larger subiculum volume in the right hippocampus. However, no differences were found in total hippocampus volume between poor metabolizers and other metabolizers.

TRANSLATIONAL PSYCHIATRY (2022)

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Article Environmental Sciences

Short-term effects of exposure to ambient PM1, PM2.5, and PM10 on ischemic and hemorrhagic stroke incidence in Shandong Province, China

Han Wu, Bingyin Zhang, Jing Wei, Zilong Lu, Min Zhao, Wenhui Liu, Pascal Bovet, Xiaolei Guo, Bo Xi

Summary: Short-term exposure to ambient PM1, PM2.5, and PM10 is associated with increased risk of stroke incidence in China. PM1 has a stronger association and larger attributable fraction to stroke than PM2.5 and PM10. Clean air policies should focus on addressing the impact of PM1.

ENVIRONMENTAL RESEARCH (2022)

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Article Endocrinology & Metabolism

Body Composition Assessment by Dual-Energy X-Ray Absorptiometry: A Useful Tool for the Diagnosis of Lipedema

Giacomo Buso, Lucie Favre, Nathalie Vionnet, Elena Gonzalez-Rodriguez, Didier Hans, Jardena Jacqueline Puder, Celine Dubath, Chin-Bin Eap, Wassim Raffoul, Tinh-Hai Collet, Lucia Mazzolai

Summary: This study aimed to investigate regional body composition by DXA in patients with lipedema and healthy controls, and to determine cut-off values of FM indices for diagnosis and staging. The results showed significant differences in FM distribution indices between groups, with the leg FM/total FM ratio being a potentially useful indicator of lipedema.

OBESITY FACTS (2022)

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Article Public, Environmental & Occupational Health

Using the New Life's Essential 8 Metrics to Evaluate Trends in Cardiovascular Health Among US Adults From 2005 to 2018: Analysis of Serial Cross-sectional Studies

Cheng Li, Yanzhi Li, Min Zhao, Cheng Zhang, Pascal Bovet, Bo Xi

Summary: According to the LE8, overall cardiovascular health (CVH) did not change among US adults from 2005 to 2018, as well as three components (diet, physical activity, and blood pressure). However, metrics such as nicotine exposure, blood lipids, and sleep health improved, while BMI and blood glucose deteriorated over time.

JMIR PUBLIC HEALTH AND SURVEILLANCE (2023)

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Article Geriatrics & Gerontology

The state of diabetes treatment coverage in 55 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 680 102 adults

David Flood, Jacqueline A. Seiglie, Matthew Dunn, Scott Tschida, Michaela Theilmann, Maja E. Marcus, Garry Brian, Bolormaa Norov, Mary T. Mayige, Mongal Singh Gurung, Krishna K. Aryal, Demetre Labadarios, Maria Dorobantu, Bahendeka K. Silver, Pascal Bovet, Jutta M. Adelin Jorgensen, David Guwatudde, Corine Houehanou, Glennis Andall-Brereton, Sarah Quesnel-Crooks, Lela Sturua, Farshad Farzadfar, Sahar Saeedi Moghaddam, Rifat Atun, Sebastian Vollmer, Till W. Baernighausen, Justine Davies, Deborah J. Wexler, Pascal Geldsetzer, Peter Rohloff, Manuel Ramirez-Zea, Michele Heisler, Jennifer Manne-Goehler

Summary: Less than one in ten people with diabetes in LMICs receive coverage of guideline-based comprehensive diabetes treatment. It is urgent for global diabetes priorities to scale up the capacity of health systems to deliver treatment not only to lower glucose but also to address cardiovascular disease risk factors, such as hypertension and high cholesterol.

LANCET HEALTHY LONGEVITY (2021)

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