Review
Oncology
Celina Amaya, Elizabeth R. Smith, Xiang-Xi Xu
Summary: Taxane drugs, such as Taxol and Taxotere, are commonly used in chemotherapy for solid tumors. However, their major side effects, including neuropathy and alopecia, limit their efficacy. A recent laboratory finding suggests that low intensity ultrasound may be an effective solution to counter taxane cytotoxicity.
Article
Biotechnology & Applied Microbiology
Mei-Fang Zhang, Wen-Liang Xie, Cheng Chen, Chun-Xiu Li, Jian-He Xu
Summary: In this study, the taxane-10 beta-hydroxylase (T10 beta H) from Taxus cuspidata was expressed and engineered in Escherichia coli. Through protein engineering, the expression and activity of T10 beta H were improved. The de novo biosynthesis of T10OH was successfully achieved in E. coli.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Alessandra Spada, Jaber Emami, Jack A. Tuszynski, Afsaneh Lavasanifar
Summary: Albumin is an attractive carrier in nanomedicine due to its high biocompatibility, ability to interact with various drugs, and active targeting potential. It has a long serum half-life of around 19 days, promoting half-life extension and targeted drug delivery. The article emphasizes the importance of albumin as a drug delivery system and highlights its potential future trends in drug delivery.
MOLECULAR PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Fabian Schneider, Lu Pan, Moritz Ottenbruch, Tatjana List, Tanja Gaich
Summary: Taxane diterpenes, derived from slow-growing evergreen shrubs known as yews, are an important family of natural products with potent anticancer properties. Among them, the complex or cyclotaxane subfamily stands out for its challenging structure and potential as interesting compounds for cancer research. Efforts towards synthesizing these complex taxanes are limited and the deconvolution strategy offers a promising approach for accessing these intricate scaffolds.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Melecio A. Perea, Brian Wang, Benjamin C. Wyler, Jin Su Ham, Nicholas R. O'Connor, Shota Nagasawa, Yuto Kimura, Carolin Manske, Maximilian Scherubl, Johny M. Nguyen, Richmond Sarpong
Summary: Chemical synthesis of natural products is often inspired by the structure and function of the target molecule, and this paper presents a unified enantiospecific approach to diverse taxane cores using (S)-carvone as the starting material, which involves skeletal remodeling and C-C bond cleavage strategies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Environmental Sciences
Ines Klein, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of chemotherapy, affecting up to 60% of cancer patients. Paclitaxel induces neuropathy in gynecological and urological cancer patients, leading to cell death and affecting both central and peripheral nervous system cells. Symptoms include pain and numbness in hands and feet, with pathomechanisms involving axonal damage and disrupted axonal transport.
Article
Oncology
Ryutaro Onaga, Tomohiro Enokida, Kazue Ito, Yuri Ueda, Susumu Okano, Takao Fujisawa, Akihisa Wada, Masanobu Sato, Hideki Tanaka, Naohiro Takeshita, Nobukazu Tanaka, Yuta Hoshi, Makoto Tahara
Summary: This study retrospectively evaluated the efficacy of taxane and platinum in the treatment of salivary gland carcinoma. The results showed that the combination of docetaxel and cisplatin had better efficacy compared to paclitaxel and carboplatin, especially in patients with adenoid cystic carcinoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ting Jiang, Ya-Nan Cao, Jin-Bu Xu, Feng Gao, Ling-Li Zheng
Summary: A series of new paclitaxel-benzoxazoles hybrids were designed based on molecular docking and activity-structure relationship studies. Palladium-catalyzed reactions were used to synthesize the hybrids, and their antiproliferative activity against human cancer cell lines was evaluated. The results showed that the hybrids exhibited high anti-tumor activity.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Satoru Yonekura, Yuichiro Endo, Hiroko Fujii, Makiko Ishikawa, Gyohei Egawa, Kenji Kabashima
Summary: Cutaneous angiosarcoma (CAS) is a rare soft-tissue sarcoma of vascular endothelial origin. Chemoresistance often occurs in CAS, but switching from one taxane-based chemotherapy to another may still be effective. The overall median survival of CAS patients who switched taxane treatment was 22.7 months, compared to 29.0 months during the first taxane treatment.
JOURNAL OF DERMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zeeshan Ali, Muhammad Sajid, Suryyia Manzoor, Muhammad Mahboob Ahmad, Muhammad Imran Khan, Noureddine Elboughdiri, Muhammad Kashif, Abdallah Shanableh, Wajdi Rajhi, Wael Mersni, Emin Bayraktar, Sahbi Ben Salem
Summary: This study reports the synthesis of a novel fluorescence-active magnetic molecularly imprinted drug carrier for the targeted delivery of an anticancer drug. In vitro and in vivo studies showed that the drug carrier exhibited good biocompatibility and targeted delivery ability.
Review
Pharmacology & Pharmacy
Anees Ahmed Khalil, Abdur Rauf, Fahad A. A. Alhumaydhi, Abdullah S. M. Aljohani, Muhammad Sameem Javed, Muhammad Arslan Khan, Imtiaz Ali Khan, Mohamed A. A. El-Esawi, Sami Bawazeer, Abdelhakim Bouyahya, Maksim Rebezov, Mohammad Ali Shariati, Muthu Thiruvengadam
Summary: Plants are a rich source of anticancer secondary metabolites, with paclitaxel being one of the most widely used anticancer drugs. The complex biosynthesis pathway of paclitaxel has led to investigations into alternative sources such as plant cell culture and heterologous expression systems. Advances in genetic engineering, microbial fermentation engineering, and recombinant techniques have increased the production of paclitaxel. Additionally, innovative drug delivery formulations have been developed to improve the delivery of paclitaxel to tumor cells.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Gang Nan, Shu-Hua Zhao, Ting Wang, Dong Chao, Ruo-Fei Tian, Wen-Jing Wang, Xin Fu, Peng Lin, Ting Guo, Bin Wang, Xiu-Xuan Sun, Xi Chen, Zhi-Nan Chen, Shi-Jie Wang, Hong-Yong Cui
Summary: This study investigates the role and mechanisms of CD147 in paclitaxel resistance. It demonstrates that CD147 protects cancer cells from paclitaxel-induced apoptosis and interacts with the C-terminal tail of RanBP1 to regulate microtubule stability and dynamics as well as response to paclitaxel treatment. Targeting CD147 may be a potential strategy for preventing paclitaxel resistance.
Article
Chemistry, Organic
Shota Iiyama, Keisuke Fukaya, Yu Yamaguchi, Ami Watanabe, Hiroaki Yamamoto, Shota Mochizuki, Ryosuke Saio, Takashi Noguchi, Takeshi Oishi, Takaaki Sato, Noritaka Chida
Summary: The total synthesis of paclitaxel is achieved through a double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone, efficiently installing a bridgehead olefin and C-5/C-13 hydroxy groups in one step. Additionally, a novel Ag-promoted oxetane formation method is used to smoothly construct the tetracyclic framework of paclitaxel.
Article
Cell Biology
Ines Klein, Jorg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann, Carsten Mueller, Tim Hucho, Manuel Koch, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel, but the mechanisms of paclitaxel transport into neurons are not well understood. This study identified OATP1A1 and OATP1B2 as the primary neuronal transporters for paclitaxel and suggested that inhibiting these transporters may prevent paclitaxel-induced neuropathy.
Article
Multidisciplinary Sciences
Elizabeth A. Sigworth, Samuel M. Rubinstein, Sandip Chaugai, Donna R. Rivera, Philip D. Walker, Qingxia Chen, Jeremy L. Warner
Summary: This study conducted a systematic review and meta-analysis on docetaxel and paclitaxel, establishing their dose-toxicity equivalence. The findings provide guidance for oncologists in terms of treatment switching and dosing decisions, with the aim of reducing the risk of chemotherapy-induced peripheral neuropathy (CIPN) in patients.
Review
Pharmacology & Pharmacy
Laura B. Ramsey, Li Gong, Seung-Been Lee, Jonathan B. Wagner, Xujia Zhou, Katrin Sangkuhl, Solomon M. Adams, Robert J. Straka, Philip E. Empey, Erin C. Boone, Teri E. Klein, Mikko Niemi, Andrea Gaedigk
Summary: PharmVar provides star allele nomenclature for the SLCO1B1 gene, which plays an important role in drug transport and metabolism. The standardized nomenclature has been adopted by CPIC and incorporated into guidelines.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Roseann S. Gammal, Munir Pirmohamed, Andrew A. Somogyi, Sarah A. Morris, Christine M. Formea, Amanda L. Elchynski, Kazeem A. Oshikoya, Howard L. McLeod, Cyrine E. Haidar, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Mary Relling
Summary: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with the development of acute hemolytic anemia in the presence of oxidative stress. This guideline provides information on using G6PD genotype for diagnosing G6PD deficiency and categorizes medications based on their risk level in individuals with G6PD deficiency. High-risk medications should be avoided, medium-risk medications should be used with caution, and low-risk medications can be used without considering the G6PD phenotype.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Binglan Li, Katrin Sangkuhl, Karl Keat, Ryan M. M. Whaley, Mark Woon, Shefali Verma, Scott Dudek, Sony Tuteja, Anurag Verma, Michelle Whirl-Carrillo, Marylyn D. D. Ritchie, Teri E. E. Klein
Summary: Pharmacogenomics (PGx) investigates the genetic influence on drug response and is important for precision medicine. The challenge lies in interpreting PGx testing results for clinical decision support. PharmCAT has been designed to provide automatic interpretations of patient genetic data and generate reports with guideline recommendations. It has introduced new features, such as a VCF Preprocessor and functionalities for PGx research.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Chad A. Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl, J. Kevin Hicks, Jeffrey R. Strawn, Ajeet B. Singh, Gualberto Ruano, Daniel J. Mueller, Evangelia Eirini Tsermpini, Jacob T. Brown, Gillian C. Bell, J. Steven Leeder, Andrea Gaedigk, Stuart A. Scott, Teri E. Klein, Kelly E. Caudle, Jeffrey R. Bishop
Summary: Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacologic treatments for major depressive and anxiety disorders. Genetic variation in CYP2D6, CYP2C19, and CYP2B6 can affect the metabolism of these antidepressants, potentially impacting dosing, efficacy, and tolerability. The SLC6A4 and HTR2A genes have been studied for their relationship with efficacy and side effect profiles of these drugs. This guideline updates and expands on the role of genetic factors in antidepressant response and provides recommendations for using genotype results to guide prescribing decisions.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Akinyemi Oni-Orisan, Sony Tuteja, Glenda Hoffecker, D. Max Smith, Matteo Castrichini, Kristine R. Crews, William A. Murphy, Nam H. K. Nguyen, Yimei Huang, Christelle Lteif, Kevin A. Friede, Kelan Tantisira, Folefac Aminkeng, Deepak Voora, Larisa H. Cavallari, Michelle Whirl-Carrillo, Julio D. Duarte, Jasmine A. Luzum
Summary: Pharmacogenetics has the potential to improve clinical outcomes for cardiovascular diseases by reducing adverse drug effects and enhancing therapeutic efficacy. However, limited education, outdated recommendations, and misconceptions among healthcare providers hinder the implementation of cardiovascular pharmacogenetics. This tutorial aims to provide introductory education on the use of cardiovascular pharmacogenetics in clinical practice and promote a greater understanding among healthcare providers.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Genetics & Heredity
David T. Miller, Kristy Lee, Noura S. Abul-Husn, Laura M. Amendola, Kyle Brothers, Wendy K. Chung, Michael H. Gollob, Adam S. Gordon, Steven M. Harrison, Ray E. Hershberger, Teri E. Klein, C. Sue Richards, Douglas R. Stewart, C. L. Martin
Summary: “Disclaimer: This statement is a voluntary educational resource for medical professionals, aimed at providing quality medical services. It does not guarantee successful medical outcomes and clinicians should use their own professional judgment in determining the appropriateness of specific procedures or tests. The views expressed may not reflect those of authors' employers or affiliated institutions.”
GENETICS IN MEDICINE
(2023)
Review
Orthopedics
Samantha Williams, Chandler Ligas, Lawrence Oloff, Teri E. E. Klein
Summary: Tendinopathy of the foot and ankle remains a poorly understood clinical problem. This article reviewed genomic advances in understanding the disease and its potential application in risk stratification and development of preventative or therapeutic agents. The research identified genetic risk factors, such as collagen gene polymorphisms, associated with chronic tendinopathy. Changes in the extracellular matrix and cytokine expression were also observed, which contribute to the pathology of tendinopathy. By targeting the underlying epigenetic mediators, therapeutic interventions can be developed to minimize side effects.
FOOT & ANKLE SPECIALIST
(2023)
Article
Genetics & Heredity
Binglan Li, Katrin Sangkuhl, Ryan Whaley, Mark Woon, Karl Keat, Michelle Whirl-Carrillo, Marylyn D. Ritchie, Teri E. Klein
Summary: Pharmacogenomics is a crucial part of precision medicine. By analyzing genetic data from the UK Biobank, we estimated the pharmacogenomic frequencies in different biogeographic groups. The frequencies varied between each group. We also identified rare or seldom tested non-functional alleles that were previously overlooked. These estimated frequencies are disseminated through the Pharmacogenomics Knowledgebase, providing guidance for future research and clinical genetic testing.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Pharmacology & Pharmacy
Amy J. Turner, Charity Nofziger, Bronwyn E. Ramey, Reynold C. Ly, Chad A. Bousman, Jose A. G. Agundez, Katrin Sangkuhl, Michelle Whirl-Carrillo, Simone Vanoni, Henry M. Dunnenberger, Gualberto Ruano, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Ann M. Moyer, Andrea Gaedigk
Summary: The Pharmacogene Variation Consortium (PharmVar) provides nomenclature and a comprehensive summary for the highly polymorphic human CYP2D6 gene locus and its structural variation. Accurate prediction of a patient’s CYP2D6 phenotype requires testing for structural variants, including gene deletions, duplications, hybrid genes, and combinations thereof.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pathology
Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, Ron H. N. van Schaik, Michelle Whirl-Carrillo, Karen E. Weck
Summary: The Association for Molecular Pathology PGx Working Group provides recommendations for defining key attributes of pharmacogenetic alleles and minimum variant sets for clinical testing. Their goal is to promote standardization of PGx gene/allele testing across clinical laboratories.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Chad A. Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl, J. Kevin Hicks, Jeffrey R. Strawn, Ajeet B. Singh, Gualberto Ruano, Daniel J. Mueller, Evangelia Eirini Tsermpini, Jacob T. Brown, Gillian C. Bell, J. Steven Leeder, Andrea Gaedigk, Stuart A. Scott, Teri E. Klein, Kelly E. Caudle, Jeffrey R. Bishop
PHARMACOGENETICS AND GENOMICS
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
N. Gonzaludo, S. Kingan, J. Harting, P. Baybayan, T. Han, L. Arbiza, B. Li, K. Sangkuhl, M. Woon, R. Whaley, M. Whirl-Carrillo, Y. Yang, T. E. Klein, N. Hammond, S. A. Scott
PHARMACOGENETICS AND GENOMICS
(2023)
