Article
Neurosciences
Yue Li, Cuiping You, Zhenchuan Liu, Feng He, Fuchun Zhao, Xiaojie Song, Zhongxiang Xie, Shuai Wei, Yongfang Yang, Hongyan Wei, Fengyuan Che, Jixu Yu
Summary: This study found that CYP2C8 gene polymorphisms are associated with an increased risk of HICH and poor outcomes in the Han Chinese population.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Genetics & Heredity
Aleksandra Ekkert, Aleksandra Sliachtenko, Julija Grigaite, Birute Burnyte, Algirdas Utkus, Dalius Jatuzis
Summary: The etiology of ischemic stroke is multifactorial, and genetic causes play a significant role in early-onset stroke. Several stroke classification systems based on genetic information have been proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke. Genome-wide association studies and next generation sequencing are increasingly used. Some monogenic disorders cause well-known clinical manifestations, while polygenic disorders are more common. Current advances in human genetics provide opportunities for personalized prevention and novel treatment possibilities. Genetic risk scores and extended polygenic risk scores can contribute to better primary stroke prevention.
Article
Cardiac & Cardiovascular Systems
Nicholas A. Marston, Parth N. Patel, Frederick K. Kamanu, Francesco Nordio, Giorgio M. Melloni, Carolina Roselli, Yared Gurmu, Lu-Chen Weng, Marc P. Bonaca, Robert P. Giugliano, Benjamin M. Scirica, Michelle L. O'Donoghue, Christopher P. Cannon, Christopher D. Anderson, Deepak L. Bhatt, Philippe Gabriel Steg, Marc Cohen, Robert F. Storey, Peter Sever, Anthony C. Keech, Itamar Raz, Ofri Mosenzon, Elliott M. Antman, Eugene Braunwald, Patrick T. Ellinor, Steven A. Lubitz, Marc S. Sabatine, Christian T. Ruff
Summary: Genome-wide association studies have identified single-nucleotide polymorphisms associated with an increased risk of stroke. A genetic risk score (GRS) using 32 single-nucleotide polymorphisms was found to be a strong, independent predictor of ischemic stroke across a broad spectrum of subjects with cardiometabolic disease. In patients with atrial fibrillation and lower CHA(2)DS(2)-VASc scores, the GRS identified patients with a risk level comparable to those with higher scores.
Article
Clinical Neurology
Bengt Zoller, MirNabi Pirouzifard, Magnus P. Lindgren, Jan Sundquist, Kristina Sundquist
Summary: This study found that a family history of short sibling survival after IS is associated with mortality after IS for younger male subjects.
Article
Neurosciences
Minjie Shao, Youbing Mao, Qing Hong, Xinchun Jin, Haibo Cai, Xingyang Yi
Summary: To investigate the association of CYP metabolic pathway-related genetic polymorphisms with ischemic stroke susceptibility and carotid plaque stability in southeast China, a study was conducted in Wenling First People's Hospital. The results showed that the EPHX2 G860A polymorphism may reduce the susceptibility to ischemic stroke, while other CYP gene SNPs were not associated with stroke in this region. Additionally, the CYP3A5 polymorphism was found to be related to carotid plaque instability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Chemistry, Analytical
Xiangge Tian, Tao Liu, Mingyue Zhu, Jiao Peng, Jingnan Cui, Lei Feng, Xiaokui Huo, Jinsong Yuan, Xiaochi Ma
Summary: In this study, an endoplasmic reticulum (ER)-targeting near-infrared fluorescent probe ER-BnXPI was developed for monitoring CYP2J2 activity. The probe exhibited high selectivity and sensitivity towards CYP2J2 among various cytochrome P450 isoforms and effectively localized to the ER. Furthermore, the probe successfully imaged the variation behavior of CYP2J2 under the ER stress model in living cells and in different tumors, distinguishing tumor tissues from para-cancerous tissues. These findings suggest that ER-BnXPI could be a promising tool for studying the physiological function of CYP2J2 and may provide novel approaches for the diagnosis and therapy of CYP2J2-related vascular inflammation and cancer.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Robert Valencia, Wesam Bassiouni, Ahmed M. Darwesh, Raj Bapuji, John M. Seubert
Summary: Cytochrome P450s (CYPs) are a superfamily of monooxygenases with diverse biological roles. CYP2J2, highly expressed in the heart, plays a crucial role in metabolizing fatty acids to produce lipid mediators involved in cardiac homeostasis and protection. Understanding the function and impact of CYP2J2 in the heart is important for cardiac health and disease. This review examines the current knowledge on cardiac CYP2J2, including its role in cardioprotection, small molecule modulators, effects of CYP2J2 substrates, and implications of CYP2J2 polymorphisms and sexual dimorphism. Further research is needed to elucidate the clinical relevance of individual factors and identify the targets and activities of CYP2J2-derived metabolites.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Genetics & Heredity
Luyang Zhang, Weishi Liu, Wenxian Sun, Xin Wang, Mengke Tian, Lu-Lu Pei, Kai Liu, Jing Liang, Lue Zhou, Jie Lu, Mingming Ning, Ferdinando S. Buonanno, Yuming Xu, Bo Song
Summary: The bidirectional and multivariable Mendelian randomization studies demonstrated causal links between HF and IS, with HF affecting all causes of IS and LAS, and IS affecting HF, particularly CES. Further investigation with genetic information from other ancestries or etiologies of HF is needed to confirm these potential causal links.
FRONTIERS IN GENETICS
(2021)
Article
Clinical Neurology
Xiao-Dong Deng, Jian-Lin Ke, Tai-Yu Chen, Qin Gao, Zhuo-Lin Zhao, Wei Zhang, Huan Liu, Ming-Liang Xiang, Li-Zhen Wang, Ying Ma, Yun Liu
Summary: In this study, the ERCC1 rs3212986 polymorphism was found to be associated with susceptibility to ischemic stroke in a Chinese Han population. The A allele of rs3212986 was found to be related to increased risk of ischemic stroke. The altered expression of the ERCC1 gene caused by the rs3212986 polymorphism may be involved in the pathophysiological process of ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li, Shaoting Huang, Zhaochun Wu, Jiawen He, Shaofeng Chen, Fu Deng, Peiyi Zhu, Wangtao Zhong, Bin Zhao, Guoda Ma, You Li
Summary: This study evaluated the correlation between calgranulin gene variants and susceptibility to ischemic stroke in the Southern Chinese population. The results showed that certain calgranulin gene variants were associated with an increased or decreased risk of stroke. Additionally, specific haplotypes were also linked to an increased risk of stroke. Furthermore, the gene variants were associated with stroke subtypes and clinical characteristics.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ruixia Zhu, Tongling Xiao, Qianwen Wang, Yating Zhao, Xu Liu
Summary: The study revealed a significant association between MEG3 rs4081134 AA genotype and the risk of stroke recurrence, particularly for patients with large-artery atherosclerotic stroke, especially in elderly individuals, non-smokers, non-drinkers, and hypertensive patients. The findings suggest that MEG3 rs4081134 may serve as a useful biomarker and potential therapeutic target in the recurrence of ischemic stroke. Further research is needed to validate the results and explore the underlying molecular mechanisms.
METABOLIC BRAIN DISEASE
(2021)
Review
Cardiac & Cardiovascular Systems
Johanna Ernst, Hannelore Ehrenreich, Karin Weissenborn, Gerrit M. Grosse
Summary: In this study, researchers identified the genetic variants associated with cryptogenic strokes by screening relevant research. However, the associations were limited to a few polymorphisms. Future studies should address the limitation of low granularity in clinical data to advance the promising approach of elucidating stroke causes at the genetic level.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Daria Mochly-Rosen, Che-Hong Chen, Yung-Po Liaw
Summary: This study found that Taiwanese adults with ALDH7A1 rs12514417 TG + GG genotype and alcohol consumption of at least 150 ml/week have a higher risk of ischemic stroke. The interaction between age, BMI, ALDH7A1 genotype, and alcohol consumption may play an important role in the occurrence of stroke.
NUTRITION & METABOLISM
(2022)
Article
Clinical Neurology
Malin Dorvall, Annie Pedersen, Jan P. Dumanski, Martin Soderholm, Arne G. Lindgren, Tara M. Stanne, Christina Jern
Summary: This study found an association between mosaic loss of chromosome Y (LOY) in male patients and poor outcome after ischemic stroke, which remained significant in patients not receiving recanalization therapy. Further studies on LOY and other somatic genetic alterations in larger stroke cohorts are needed.
Article
Behavioral Sciences
Fan Cheng, Xiao-Min Si, Gong-Li Yang, Lan Zhou
Summary: This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.
BRAIN AND BEHAVIOR
(2021)
Article
Cardiac & Cardiovascular Systems
Wu He, Gang Yuan, Yu Han, Yongcui Yan, Gen Li, Chengcheng Zhao, Jingshan Shen, Xiangrui Jiang, Chen Chen, Li Ni, Dao Wen Wang
Summary: Long-term continuous use of glimepiride is associated with better survival, fewer hospitalizations and emergency visits for heart failure, and fewer hospitalizations for acute myocardial infarction or stroke. High-dose glimepiride has greater cardiovascular protective advantages than low-dose glimepiride. The cardiovascular protective effect of glimepiride may be related to the increase in epoxyeicosatrienoic acid levels through soluble epoxide hydrolase inhibition.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.
Review
Biology
Xiang Nie, Jiahui Fan, Dao Wen Wang
Summary: Cardiac fibrosis is a significant issue in cardiovascular diseases, with molecular mechanisms involving TGF-beta signaling, extracellular matrix synthesis and degradation, and non-coding RNAs. Long noncoding RNAs play a crucial role in myocardial fibrosis and can regulate fibrosis by affecting miRNA expression, TGF-beta signaling, and ECM synthesis. Understanding these mechanisms can guide the development of novel therapeutic strategies to prevent or reverse cardiac fibrosis.
Article
Biochemistry & Molecular Biology
Jiali Nie, Yu Han, Zhiyuan Jin, Weijian Hang, Hongyang Shu, Zheng Wen, Li Ni, Dao Wen Wang
Summary: Editing MYBPC3 gene using CRISPR/Cas9 system in vivo can rescue the phenotype of rats with hypertrophic cardiomyopathy. The editing corrected some mutations, restored MYBPC3 protein expression, and normalized the HCM phenotype.
Article
Cardiac & Cardiovascular Systems
Chen Chen, Wu He, Dao Wen Wang
Summary: In November 2019, Wuhan became the epicenter of the COVID-19 outbreak caused by the novel SARS-CoV-2 infection. The emergence of new strains and mutations of the virus posed a serious global health threat. COVID-19-associated cardiac injury, ranging from mild cases to fulminant myocarditis, is not uncommon, and the overactivated immune response and inflammatory storm play a crucial role in its pathogenesis. Early identification and diagnosis are crucial for the treatment of COVID-19-associated myocarditis.
Article
Oncology
Hong Yang, Rui Li, Fei Ma, Yujian Liu, Xingwei He, Qiao Yang, Dao Wen Wang, Hesong Zeng, Hong Wang
Summary: This study aimed to explore and determine whether echocardiographic phenotype provides value for further risk stratification and guiding treatment in AL patients with heart failure. The results showed that right ventricular wall thickness (RVT), relative wall thickness (RWT), and left ventricular ejection fraction (LVEF) < 50% were independently associated with survival. Survival was significantly reduced in the presence of RVT >= 6.5 mm or LVEF < 50%. Echocardiographic phenotype has incremental value beyond rMayo staging for predicting survival and guiding treatment in AL patients with heart failure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jiang He, Nanxiang Ouyang, Xiaofan Guo, Guozhe Sun, Zhao Li, Jianjun Mu, Dao Wen Wang, Lixia Qiao, Liying Xing, Guocheng Ren, Chunxia Zhao, Ruihai Yang, Zuyi Yuan, Chang Wang, Chuning Shi, Songyue Liu, Wei Miao, Guangxiao Li, Chung-Shiuan Chen, Yingxian Sun
Summary: This study tested the effectiveness of a non-physician community health-care provider-led intervention for hypertension. The results showed that this intervention can effectively reduce the risk of cardiovascular disease and death.
Review
Biology
Wu He, Ling Zhou, Ke Xu, Huihui Li, James Jiqi Wang, Chen Chen, DaoWen Wang
Summary: Myocarditis is an inflammatory cardiac disease that causes the destruction of myocardial cells, infiltration of inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis is expanding with the emergence of new pathogens and drugs. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis is gaining attention. Immunopathological processes play a significant role in the development and prognosis of myocarditis. Excessive immune activation can cause severe myocardial injury, while chronic inflammation can result in cardiac remodelling and dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis remains controversial, and immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and provides new perspectives on immunomodulatory therapies.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Summary: Intensive glycemic control is insufficient for reducing the risk of heart failure in patients with diabetes mellitus. MiR-320 and CD36 mutually enhance each other's expression, forming a positive feedback loop that sustains a hyperlipidemic state in the heart.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, Research & Experimental
Rong Xie, Jiahui Fan, Jianpei Wen, Kunying Jin, Jiabing Zhan, Shuai Yuan, Yuyan Tang, Xiang Nie, Zheng Wen, Huaping Li, Chen Chen, Dao Wen Wang
Summary: Diabetes can directly cause cardiac injury, leading to cardiomyopathy. In this study, the protective role of ZNF593-AS in diabetic cardiomyopathy was identified. ZNF593-AS attenuated cardiomyocyte apoptosis and inflammation by suppressing the phosphorylation and activation of IRF3, suggesting that ZNF593-AS may be a potential therapeutic target for diabetic cardiomyopathy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Jiaqi Dai, Tao Wang, Ke Xu, Yang Sun, Zongzhe Li, Peng Chen, Hong Wang, Dongyang Wu, Yanghui Chen, Lei Xiao, Hao Liu, Haoran Wei, Rui Li, Liyuan Peng, Ting Yu, Yan Wang, Zhongsheng Sun, Dao Wen Wang
Summary: Previous studies have identified differences in symptom severity and prognosis among patients with hypertrophic cardiomyopathy (HCM), suggesting the presence of potential HCM subtypes. In this study, consensus clustering was performed on echocardiography features of 793 HCM patients to identify potential subtypes. Machine learning modeling and interactome network detection techniques were used to explore the relationship between phenotype and genotype based on whole-exome sequencing data. Two subtypes were identified: subtype 2 characterized by stable course with asymmetric septal hypertrophy, and subtype 1 characterized by aggressive progression and left ventricular systolic dysfunction. Machine learning modeling based on personal whole-exome data accurately predicted subtype propensities using 46 genes with high mutation burden. Another cohort replicated the findings, showing increased left ventricular end-diastolic diameter and reduced ejection fraction in patients predicted as subtype 1. Echocardiography and genetic screening for the 46 genes can be used to classify HCM into two subtypes with distinct clinical outcomes.
FRONTIERS OF MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Zuowen He, Xin Xu, Qu Zhao, Hu Ding, Dao Wen Wang
Summary: This article summarizes the characteristics, etiology, diagnosis, and treatment of vasospastic angina (VSA), with a focus on the role of inflammation. It provides new insights into the understanding of VSA.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Huihui Li, Mingzhi Zhang, Quanyi Zhao, Wanqing Zhao, Yan Zhuang, Jin Wang, Weijian Hang, Zheng Wen, Li Wang, Chen Chen, Dao Wen Wang
Summary: This study reveals the pathogenesis of fulminant myocarditis (FM) and suggests potential therapeutic strategies. Healthy cardiomyocytes lose their function and differentiate into pro-angiogenic and pro-inflammatory cells in FM. Neutrophils, after migrating to the heart, continuously attract peripheral neutrophils via specific signals, resulting in their acute accumulation in the heart. Moreover, neutrophils can amplify the inflammatory response by recruiting and activating pro-inflammatory cells. Blockade of the self-recruiting loop of neutrophils substantially alleviates FM in mice.
Article
Cardiac & Cardiovascular Systems
Mei-Yan Dai, Yong-Cui Yan, Lu-Yun Wang, Chun-Xia Zhao, Dao-Wen Wang, Jian-Gang Jiang
Summary: Retrospective analysis of 150 patients with fulminant myocarditis revealed marked ECG abnormalities, including significantly decreased QRS amplitudes and various arrhythmias, which can serve as preliminary clues for the diagnosis of this condition.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yanru Zhao, Huaping Li, Hengzhi Du, Zhongwei Yin, Mengying He, Jiahui Fan, Xiang Nie, Yang Sun, Huiying Hou, Beibei Dai, Xudong Zhang, Yuanyuan Cai, Kunying Jin, Nan Ding, Zheng Wen, Jiang Chang, Chen Chen, Dao Wen Wang
Summary: This study found that KSHV infection is a risk factor for dilated cardiomyopathy, and the KSHV-encoded miRNA kshv-miR-K12-1-5p may be involved in the development of heart disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)