Article
Biochemistry & Molecular Biology
Ummie Umaiera Mohd. Johan, Raja Noor Zaliha Raja Abd Rahman, Nor Hafizah Ahmad Kamarudin, Wahhida Latip, Mohd Shukuri Mohamad Ali
Summary: This study characterized a new carboxylesterase, EstD9, from the thermophilic bacterium Anoxybacillus geothermalis D9. EstD9 showed excellent catalytic performance and stability, making it a suitable catalyst for industrial bioprocesses under harsh conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biophysics
Ummie Umaiera Mohd Johan, Raja Noor Zaliha Raja Abd Rahman, Nor Hafizah Ahmad Kamarudin, Mohd Shukuri Mohamad Ali
Summary: Carboxylesterases are important esterases that catalyze the cleavage of ester linkages. They are widely distributed in nature and play crucial roles in various industries. Investigating their mechanisms and structural engineering is of increasing interest for the advancement of enzymology field.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Yasuhiro Uno, Takahiro Mikami, Yasuko Tsukazaki, Yasuharu Nakanishi, Norie Murayama, Shinichi Ikushiro, Hideshi Tsusaki, Hiroshi Yamazaki
Summary: In cynomolgus and rhesus macaques, genetic variants in UGT1A1/6/9 genes were identified, including unique variants specific to each species. The study suggests that these variants, such as UGT1A1G69R, may affect the glucuronidation of drugs mediated by UGT1A1 in these macaque species.
Review
Medicine, General & Internal
Ivana Budic, Tatjana Jevtovic Stoimenov, Dimitrije Pavlovic, Vesna Marjanovic, Ivona Djordjevic, Marija Stevic, Dusica Simic
Summary: Individual variability in response to anesthesia drugs is common and influenced by genetic and environmental factors. Propofol, the most common intravenous anesthetic, can be affected by genetic factors such as gene polymorphisms. However, there is a need for further research on multiple pathways to understand the individual differences in propofol pharmacokinetics and pharmacodynamics.
FRONTIERS IN MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jianxing Chen, Huidong Wang, Jing Li, Shuqin Liu, Benke Li, Yujiang Sun, Huaidong Wang, Dugarjaviin Manglai
Summary: The origins, domestication, and genetic structure of Chinese Mongolian horses (CMH) have not been well studied. In this research, the genetic structure and relationships of CMH, Sanhe horses, and Thoroughbred were investigated using creatine kinase (muscle isoenzyme; CKM) variations. Significant genetic differences were observed between Thoroughbred and Chinese horse populations, while minor differences were found among Chinese horse populations in terms of CKM intron sequences. This suggests different domestication histories, breeding measures, and origins for these horse populations.
ANIMAL BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Sumbal Rasheed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran, Mohammed A. Assiri
Summary: Krupple-Like family of transcription factor-14 (KLF14) is a crucial gene involved in various biological functions and pathological mechanisms. It controls the expression of multiple genes and influences lipid metabolism, glucose regulation, insulin sensitivity, as well as cell apoptosis, proliferation, and differentiation. KLF14 has also been used as an epigenetic biomarker for estimating chronological age. Genetic variations in KLF14, especially in adipose tissues, are associated with dyslipidemia, insulin resistance, and glucose intolerance. The prevalence of these genetic polymorphisms varies among different populations due to ethnic differences and epigenetic modifications, and they can be influenced by environmental and physiological factors such as diet, age, gender, and obesity.
Article
Genetics & Heredity
Jaroslav A. Hubacek, Lucie Dlouha, Vera Adamkova, Dana Dlouha, Lukas Pacal, Katerina Kankova, David Galuska, Vera Lanska, Jiri Veleba, Terezie Pelikanova
Summary: This study demonstrates that genetic risk scores (GRS) can be significant predictors of type 2 diabetes mellitus (T2DM) development and its complications. By considering possible ethnic or population-specific differences, GRS can help quantify the individual's genetic risk.
Article
Genetics & Heredity
Muhammad Ahmad Yahaya, Hussein Shimelis, Baloua Nebie, Chris Ochieng Ojiewo, Abhishek Rathore, Roma Das
Summary: This study assessed the genetic diversity and population structure of 200 sorghum accessions using diversity arrays technology (DArT)-derived single nucleotide polymorphism (SNP) markers. The results showed a high level of genetic diversity among the accessions, which will be useful for enhancing sorghum breeding programs in West Africa by developing new gene pools and novel genotypes. Several distantly related sorghum accessions were identified, indicating the wide genetic diversity within the crop.
Article
Rheumatology
Gudny Ella Thorlacius, Lina Hultin-Rosenberg, Johanna K. Sandling, Matteo Bianchi, Juliana Imgenberg-Kreuz, Pascal Pucholt, Elke Theander, Marika Kvarnstrom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Daniel Hammenfors, Kathrine Skarstein, Malin V. Jonsson, Eva Baecklund, Lara A. Aqrawi, Janicke Liaaen Jensen, Oyvind Palm, Andrew P. Morris, Jennifer R. S. Meadows, Solbritt Rantapaa-Dahlqvist, Thomas Mandl, Per Eriksson, Lars Lind, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Lars Ronnblom, Marie Wahren-Herlenius, Gunnel Nordmark
Summary: The clinical presentation of primary Sjogren's syndrome (pSS) varies widely. A multicentre study identified two patient subgroups based on the presence of SSA/SSB antibodies and genetic markers in the HLA region, with strong association signals found in HLA-DQA1 locus for the antibody-positive subgroup. Replication confirmed the association with MHC class I and II variants, indicating distinct clinical manifestations in pSS subgroups.
Article
Medicine, Research & Experimental
Xinwen Wang, Lucy Her, Jingcheng Xiao, Jian Shi, Audrey H. Wu, Barry E. Bleske, Hao-Jie Zhu
Summary: The CES1 G143E variant significantly impairs trandolapril activation in the human liver under in vitro conditions, but has only a modest impact on the PK and PD of trandolapril in healthy human subjects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Kang-Rae Kim, Sang Ki Kim, Mu-Sung Sung, Jeong-Nam Yu
Summary: This study investigated the genetic diversity and structure of the Korean endemic aucha perch (Coreoperca herzi) using mitochondrial DNA data. The results showed significant genetic differentiation among different water systems and confirmed the origin of a translocated population. This study provides basic data for the conservation of C. herzi.
Review
Chemistry, Medicinal
Yeo-Jung Kwon, Sangyun Shin, Young-Jin Chun
Summary: Human cytochrome P450 enzymes of the CYP1 family are critical in the metabolism of various substrates related to cancer pathogenesis and the pathogenesis of several human diseases, particularly in the activation and inactivation of therapeutic drugs. Their role in diseases and drug metabolism has attracted significant interest in the scientific community for the development of novel therapeutic strategies.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Zahid Nabi Sheikh, Vikas Sharma, Rafiq Ahmad Shah, Shilpa Raina, Maha Aljabri, Javid Iqbal Mir, Naser AlKenani, Khalid Rehman Hakeem
Summary: Genomic characterization of 50 phenotypically variable apricot accessions using SSR markers revealed genetic variability and associations among accessions. The results showed an average number of alleles per locus of 3.89, effective number of alleles per locus of 1.882, and polymorphic information content values ranging from 0.464 to 0.104.
Article
Plant Sciences
Naoko Emura, Tomoaki Muranaka, Takaya Iwasaki, Mie N. Honjo, Atsushi J. Nagano, Yuji Isagi, Hiroshi Kudoh
Summary: The study on S. taccada plant reveals that fruit morphology can strongly influence genetic structure. Beach populations bridge the heterogeneous landscapes by producing two different fruit types, while elevated sites rely on bird dispersal of the pulp morph to achieve genetic dispersal. The differences in fruit morphology lead to contrasting patterns of gene flow.
Article
Biochemistry & Molecular Biology
Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod, Yijing He
Summary: The study demonstrates that propranolol pretreatment can enhance the propagation and therapeutic efficacy of T1012G virus in gastric cancer by regulating the STAT3-PKR signaling cascade, even in the presence of type I interferons.
CELL AND BIOSCIENCE
(2021)
Article
Genetics & Heredity
Farida S. Akhtari, Adrian J. Green, George W. Small, Tammy M. Havener, John S. House, Kyle R. Roell, David M. Reif, Howard L. McLeod, Timothy Wiltshire, Alison A. Motsinger-Reif
Summary: Cancer patients show a wide range of inter-individual variability in response and toxicity to anticancer drugs, largely influenced by genetic variation. By conducting a genome-wide association study, the NQO1 gene was identified to be associated with the dose-response of multiple anticancer drug treatments, including new associations with additional treatments. Baseline gene expression of NQO1 was found to be positively correlated with response for the majority of the treatments surveyed.
Article
Pharmacology & Pharmacy
Mai Nagaoka, Tatsuki Fukami, Fumiya Kisui, Takuya Yamada, Yoshiyuki Sakai, Kiyomichi Tashiro, Takuo Ogiso, Keigo Konishi, Shiori Honda, Keiya Hirosawa, Masataka Nakano, Miki Nakajima
Summary: This study demonstrated the significance of AADAC in ketoconazole-induced toxicity through experiments on Aadac knockout mice, showing that AADAC deficiency exacerbates liver injury and steroidogenesis inhibition caused by ketoconazole. The findings suggest that the hydrolysis of ketoconazole by AADAC can mitigate ketoconazole-induced toxicities.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Julia C. F. Quintanilha, Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, Flora Mulkey, Jai N. Patel, Daniel L. Hertz, Elizabeth Claire Dees, Howard L. McLeod, Monica Bertagnolli, Hope Rugo, Hedy L. Kindler, William Kevin Kelly, Mark J. Ratain, Deanna L. Kroetz, Kouros Owzar, Bryan P. Schneider, Danyu Lin, Federico Innocenti
Summary: A genome-wide association study (GWAS) meta-analysis was conducted in European ancestry bevacizumab-treated patients, identifying significant SNPs associated with hypertension and proteinuria, providing new markers for predicting toxicities induced by bevacizumab.
BRITISH JOURNAL OF CANCER
(2022)
Correction
Oncology
Julia C. F. Quintanilha, Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, Flora Mulkey, Jai N. Patel, Daniel L. Hertz, Elizabeth Claire Dees, Howard L. McLeod, Monica Bertagnolli, Hope Rugo, Hedy L. Kindler, William Kevin Kelly, Mark J. Ratain, Deanna L. Kroetz, Kouros Owzar, Bryan P. Schneider, Danyu Lin, Federico Innocenti
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Emma C. Hulshof, Mirjam de With, Femke M. de Man, Geert-Jan Creemers, Birgit A. L. M. Deiman, Jesse J. Swen, Saskia Houterman, Stijn L. W. Koolen, Sander Bins, Anna M. J. Thijs, Marjan M. J. Laven, Anke M. Hovels, Saskia A. C. Luelmo, Danny Houtsma, Katerina Shulman, Howard L. McLeod, Ron H. N. van Schaik, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Hans Gelderblom, Maarten J. Deenen
Summary: This study aimed to determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. The results showed that UGT1A1 genotype-guided dosing significantly reduces the incidence of febrile neutropenia in UGT1A1 PM patients treated with irinotecan, results in a therapeutically effective systemic drug exposure, and is cost-saving.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Daryl Pritchard, Jai N. Patel, Lindsay E. Stephens, Howard L. McLeod
Summary: This report compares PGx information in the FDA Table of Pharmacogenetic Associations with CPIC guidelines and finds significant differences between the two sources, including the drugs listed and gene-drug associations. FDA and CPIC have different perspectives and criteria when evaluating PGx associations and clinical validity, leading to divergent information in their respective sources.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Genetics & Heredity
Wei Li, Jielin Wan, Cuiyu Chen, Chengfang Zhou, Ping Liao, Qian Hu, Jiali Hu, Yang Wang, Yu Zhang, Cong Peng, Yuanfei Huang, Weihua Huang, Wei Zhang, Howard L. Mcleod, Yijing He
Summary: Preclinical and early clinical studies have shown that propranolol, a beta-adrenergic receptor blocker, can exert antitumor activity through cell signaling and immune function pathways. The inhibition of beta(2)-AR signaling selectively suppresses cell viability and inhibits xenograft growth, while propranolol can activate CD8(+) T cells in the tumor microenvironment. However, selective beta(1) or beta(2)-AR blockers have no significant effect on the tumor immune microenvironment. Therefore, the antitumor activity of propranolol is predominantly dependent on cell signaling rather than the activation of CD8(+) T cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Pharmacology & Pharmacy
Roseann S. Gammal, Munir Pirmohamed, Andrew A. Somogyi, Sarah A. Morris, Christine M. Formea, Amanda L. Elchynski, Kazeem A. Oshikoya, Howard L. McLeod, Cyrine E. Haidar, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Mary Relling
Summary: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with the development of acute hemolytic anemia in the presence of oxidative stress. This guideline provides information on using G6PD genotype for diagnosing G6PD deficiency and categorizes medications based on their risk level in individuals with G6PD deficiency. High-risk medications should be avoided, medium-risk medications should be used with caution, and low-risk medications can be used without considering the G6PD phenotype.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yang Wang, Fan Xiao, Yi Zhao, Chen-Xue Mao, Lu-Lu Yu, Lei-Yun Wang, Qi Xiao, Rong Liu, Xi Li, Howard L. McLeod, Bi-Wen Hu, Yu-Ling Huang, Qiao-Li Lv, Xiao-Xue Xie, Wei-Hua Huang, Wei Zhang, Cheng-Xian Guo, Jin-Gao Li, Ji-Ye Yin
Summary: This study identified novel risk loci for skin toxicity and dysphagia in nasopharyngeal carcinoma patients receiving radiotherapy, including rs6711678, rs4848597, rs4848598, rs2091255, and rs584547. Prediction models integrating genetic and clinical factors were also established.
Article
Andrology
Qian Hu, Jiali Hu, Cuiyu Chen, Yang Wang, Yu Zhang, Jielin Wan, Ouyang Jing, Hanying Yi, Shiyu Wang, Weihua Huang, Jie Liu, Wei Zhang, Howard L. McLeod, Ran Xu, Yijing He
Summary: The study found that propranolol can inhibit the growth of bladder cancer cells and induce apoptosis. It also inhibits bladder cancer growth in a mouse model. Propranolol also activates systemic antitumor immune response.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Oncology
Dongya Shen, Jia Luo, Ling Chen, Wenjuan Ma, Xiaoyuan Mao, Yu Zhang, Juyan Zheng, Yang Wang, Jielin Wan, Shiyu Wang, Jing Ouyang, Hanying Yi, Dongbo Liu, Weihua Huang, Wei Zhang, Zhaoqian Liu, Howard L. McLeod, Yijing He
Summary: In cancer cells, the PARP-1 and PARP2 proteins regulate DNA repair pathways to protect against therapy-induced DNA damage and cell death. Combining PARP inhibitors (PARPis) with radiotherapy has been effective in clinical trials, but the mechanisms underlying their action are still unclear. This study reveals that the activation of cyclic GMP-AMP synthase (cGAS) signaling by ionizing radiation (IR)-induced DNA damage leads to regulated cell death, known as ferroptosis, and an anti-tumor immune response. Additionally, a widely used PARPi called niraparib enhances cGAS-mediated ferroptosis and immune activation. The depletion of cGAS expression compromises IR-induced ferroptosis and reverses the infiltration of CD8(+) T cells in colorectal cancer models. High expression of cGAS, ATF3, and PTGS2, as well as a high density of CD8(+) T cells, is associated with a significantly higher disease-free survival rate in patients with rectal cancer after standard radiotherapy.
Article
Health Care Sciences & Services
Nephi A. Walton, Brent Hafen, Sara Graceffo, Nykole Sutherland, Melanie Emmerson, Rachel Palmquist, Christine M. Formea, Maricel Purcell, Bret Heale, Matthew A. Brown, Christopher J. Danford, Sumathi I. Rachamadugu, Thomas N. Person, Katherine A. Shortt, G. Bryce Christensen, Jared M. Evans, Sharanya Raghunath, Christopher P. Johnson, Stacey Knight, Viet T. Le, Jeffrey L. Anderson, Margaret Van Meter, Teresa Reading, Derrick S. Haslem, Ivy C. Hansen, Betsey Batcher, Tyler Barker, Travis J. Sheffield, Bhaskara Yandava, David P. Taylor, Pallavi Ranade-Kharkar, Christopher C. Giauque, Kenneth R. Eyring, Jesse W. Breinholt, Mickey R. Miller, Payton R. Carter, Jason L. Gillman, Andrew W. Gunn, Kirk U. Knowlton, Joshua L. Bonkowsky, Kari Stefansson, Lincoln D. Nadauld, Howard L. McLeod
Summary: The clinical use of genomic analysis has rapidly expanded, leading to increased availability and utility of genomic information in clinical care. Developing an infrastructure utilizing informatics tools and clinical processes is critical in facilitating the use of whole genome sequencing data for population health management. It is important to address domain-specific challenges and scale such a system to multiple clinical domains, supported by informatics tools and complementary to existing clinical processes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Correction
Pharmacology & Pharmacy
Daryl Pritchard, Jai N. Patel, Lindsay E. Stephens, Howard L. McLeod
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Health Care Sciences & Services
Neil T. Mason, Jason M. Burkett, Ryan S. Nelson, Julio M. Pow-Sang, Robert A. Gatenby, Timothy Kubal, John W. Peabody, G. Douglas Letson, Howard L. McLeod, Jingsong Zhang
Summary: Adaptive abiraterone therapy, based on mathematical modeling of tumor subpopulations, has been shown to extend time to disease progression and reduce costs compared to standard continuous abiraterone therapy in patients with metastatic CRPC. The study suggests that precision medicine strategies, like adaptive abiraterone treatment, can improve outcomes and reduce costs without the need for new drug discovery.
AMERICAN HEALTH AND DRUG BENEFITS
(2021)