Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Critical Care Medicine
Fahad H. Alahmadi, Andrew J. Simpson, Cristina Gomez, Magnus Ericsson, John-Olof Thorngren, Craig E. Wheelock, Dominic E. Shaw, Louise J. Fleming, Graham Roberts, John Riley, Stewart Bates, Ana R. Sousa, Richard Knowles, Aruna T. Bansal, Julie Corfield, Ioannis Pandis, Kai Sun, Per S. Bakke, Massimo Caruso, Pascal Chanez, Barbro Dahlen, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Florian Singer, Scott Wagers, Ian M. Adcock, Ratko Djukanovic, Kian Fan Chung, Peter J. Sterk, Sven-Erik Dahlen, Stephen J. Fowler
Summary: Low adherence is a common issue in severe asthma patients, whether measured directly or self-reported. There is poor agreement between the two methods, suggesting a disassociation between self-assessment of medication adherence and actual oral corticosteroid use, indicating that each approach may provide complementary information in clinical practice.
Article
Pediatrics
Louise Mandrup Bach, Sune Rubak, Adam Holm-Weber, Julie Prahl, Mette Hermansen, Kirsten Skamstrup Hansen, Bo Chawes
Summary: This study aimed to determine the risk factors for non-adherence to asthma treatment in preschool children. The study found that 75% of children under 6 years old diagnosed with asthma were not adherent to their medication. Increasing adherence was associated with co-existing allergies and experiencing loss of control events, while lower adherence was associated with atopic predisposition.
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Constanca Monteiro, Tiago Maricoto, Filipe Prazeres, Pedro Augusto Simoes, Jose Augusto Simoes
Summary: This study reviewed global literature to identify the main determinants of adherence to inhaled therapy for asthma and COPD. The study found that older age, good disease knowledge/literacy, obesity, good cognitive performance, higher income, being employed, and using multiple drugs/inhalers were significant determinants of adherence. However, the overall strength of the evidence was only low to moderate.
RESPIRATORY MEDICINE
(2022)
Review
Pediatrics
Christina J. Pearce, Amy H. Y. Chan, Tracy Jackson, Louise Fleming, Holly Foot, Andy Bush, Rob Horne
Summary: Adherence interventions in children with asthma vary in effectiveness. Effective intervention studies are more likely to be of high quality, tailored to individual perceptual and practical adherence barriers, and utilize multiple behavior change techniques.
PEDIATRIC PULMONOLOGY
(2022)
Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Letter
Allergy
Pinja Ilmarinen, Iida Vahatalo, Leena E. Tuomisto, Onni Niemela, Hannu Kankaanranta
Summary: The long-term adherence to inhaled corticosteroids was 75% or higher in phenotypes with the worst outcome, but did not vary significantly among clusters. Poor outcomes in the most severe phenotypes were not associated with poor adherence to inhaled corticosteroid medication.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Ye Sun, Sunit Jariwala, Marina Reznik
Summary: This study aimed to assess adherence rates to daily inhaled corticosteroids (ICS) using electronic monitoring devices (EMDs) in an inner-city, minority population in the Bronx, NY. The results showed that the adherence to ICS measured by EMDs was low, and self-reported adherence was highly overestimated.
Article
Respiratory System
Carlyne M. Averell, Francois Laliberte, Guillaume Germain, Mei Sheng Duh, Matthew D. Rousculp, Sean D. MacKnight, David J. Slade
Summary: This study highlights the importance of adherence to inhaled corticosteroid/long-acting beta 2 agonist treatment in asthma patients. Adherent patients had lower rates of overall and severe exacerbations, reduced rescue medication use, and lower healthcare resource utilization and costs. The findings emphasize the short-term clinical and economic benefits of medication adherence in asthma management.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Review
Immunology
Wenli Shang, Guizuo Wang, Yan Wang, Dong Han
Summary: This study aimed to evaluate the safety of long-term use of ICS in patients with asthma through a systematic review and meta-analysis. The results showed that, apart from mild local adverse events, the long-term use of ICS was safe for patients with asthma.
CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Arnaud Bourdin, Alberto A. Papi, Jonathan Corren, J. Christian Virchow, Megan S. Rice, Yamo Deniz, Michel Djandji, Paul Rowe, Ian D. Pavord
Summary: Dupilumab significantly reduced severe exacerbations and improved lung function and asthma control in patients with type 2-high asthma on high-dose ICS at baseline.
Article
Allergy
Ahmed Edris, Emmely W. de Roos, Michael J. McGeachie, Katia M. C. Verhamme, Guy G. Brusselle, Kelan G. Tantisira, Carlos Iribarren, Meng Lu, Ann Chen Wu, Bruno H. Stricker, Lies Lahousse
Summary: Genetic variants in CRHR1 and TBXT genes were found to be associated with poor and improved ICS response in adults with asthma, respectively. These associations may indicate specific endotypes that could potentially predict exacerbation risk and response to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Chemistry, Multidisciplinary
Elzbieta Dembowska, Aleksandra Jaron, Karolina Skoczek-Szlosser, Ewa Gabrysz-Trybek, Joanna Bladowska, Grzegorz Trybek
Summary: Asthma, a common allergic disease, affects both general health and oral health. This study observed the oral health status of 120 adult patients aged 18 to 71, finding significantly deeper pockets in the lateral segments of the dentition in all study groups, especially in the bronchial-only group. However, there was no significant worsening of periodontal status in asthma patients treated with inhalation, regardless of baseline periodontal status. The history of asthma and the use of inhaled corticosteroids (ICS) have an impact on patients' periodontal status.
APPLIED SCIENCES-BASEL
(2022)
Article
Allergy
Katsunori Masaki, Jun Miyata, Takashi Kamatani, Takae Tanosaki, Takao Mochimaru, Hiroki Kabata, Yusuke Suzuki, Koichiro Asano, Tomoko Betsuyaku, Koichi Fukunaga
Summary: This study investigated the characteristics of patients with moderate to severe asthma who showed poor adherence to inhaled corticosteroid therapy in order to identify barriers to optimal treatment. The study found that age at diagnosis is an independent risk factor for predicting poor adherence among adults with moderate to severe asthma.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Respiratory System
Catharina C. Moor, Judith C. Oppenheimer, Gizal Nakshbandi, Joachim G. J. V. Aerts, Paul Brinkman, Anke-Hilse Maitland-van der Zee, Marlies S. Wijsenbeek
Summary: Exhaled breath analysis using eNose technology shows promising results in accurately distinguishing between ILD patients and healthy controls, as well as different ILD subgroups. This noninvasive diagnostic tool could potentially be a novel biomarker for timely diagnosis in the future.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Allergy
Mahmoud I. Abdel-Aziz, Nazanin Zounemat Kermani, Anne H. Neerincx, Susanne J. H. Vijverberg, Yike Guo, Peter Howarth, Sven-Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Aletta D. Kraneveld, Anke H. van der Zee, Kian Fan Chung, Ian M. Adcock
Article
Pharmacology & Pharmacy
Paola Nicoletti, Harshad Devarbhavi, Ashish Goel, Radha Venkatesan, Chundamannil E. Eapen, Jane Grove, Samreen Zafer, Einar Bjornsson, M. Isabel Lucena, Raul J. Andrade, Munir Pirmohamed, Mia Wadelius, Dominique Larrey, Anke-Hilse Maitland-van der Zee, Luisa Ibanez, Paul B. Watkins, Ann K. Daly, Guruprasad P. Aithal
Summary: HLA genotype has a small impact on TB drug-related DILI while the role of NAT2 gene is complex. NAT2*5 frequency is lower, and NAT2*6 and NAT2*7 are more common in cases, with homozygotes for NAT2*6 and/or NAT2*7 enriched among cases.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Renate Kos, Paul Brinkman, Anne H. Neerincx, Tamara Paff, Marije G. Gerritsen, Ariana Lammers, Aletta D. Kraneveld, Harry G. M. Heijerman, Hettie M. Janssens, Jane C. Davies, Christof J. Majoor, Els J. Weersink, Peter J. Sterk, Eric G. Haarman, Lieuwe D. Bos, Anke H. Maitland-van der Zee
Summary: Targeted analysis of volatile organic compounds in exhaled breath can non-invasively identify patients with Pseudomonas aeruginosa in cystic fibrosis, with high accuracy. This provides a new approach for simplifying the diagnosis and monitoring of respiratory infections.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Dominic Fenn, Mahmoud Abdel-Aziz, Paul Brinkman, Renate Kos, Anne H. Neerincx, Josje Altenburg, E. Weersink, Eric G. Haarman, Suzanne W. J. Terheggen-Lagro, Anke H. Maitland-van der Zee, Lieuwe D. J. Bos
Summary: Culture-independent analysis of cough swabs provides an inaccurate diagnosis of lower respiratory tract colonisation and should not be used as a diagnostic test in patients with CF.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Letter
Allergy
Niels Rutjes, Ivo van den Bongaardt, Simone Hashimoto, Peter Sterk, Wim Van Aalderen, Suzanne Terheggen-Lagro, Paul Brinkman, Anke-Hilse Maitland - van der Zee, Marc van der Schee, Eric Haarman
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Letter
Allergy
Abena S. Amoah, Maria Prins, Elisabeth H. D. Bel, Wytske J. Fokkens, Aeilko H. Zwinderman, Maria Yazdanbakhsh, Anke H. Maitland-van der Zee, Ronald van Ree
Review
Health Care Sciences & Services
Somayeh Bazdar, Anastasia K. A. L. Kwee, Laura Houweling, Yolanda de Wit-van Wijck, Firdaus A. A. Mohamed Hoesein, George S. Downward, Esther J. Nossent, Anke H. Maitland-van der Zee
Summary: Long COVID refers to the persistence of COVID-19 symptoms after the initial infection, and it is associated with lung damage. This systematic review focuses on lung imaging and its findings in patients with long COVID. The study identified 31 articles that reported imaging findings of 342 long COVID patients, with computed tomography (CT) being the most common modality used. Various types of lung abnormalities were observed, but a significant proportion of patients had normal CT findings. Further research is needed to understand the role of lung and organ damage in long COVID.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Feiko J. M. de Jong, Thijs T. Wingelaar, Paul Brinkman, Pieter-Jan A. M. van Ooij, Anke H. van der Zee, Markus W. Hollmann, Rob A. van Hulst
Summary: The study assessed whether VOCs in exhaled breath after COMEX-30 treatment are early markers of hyperoxic stress and/or POT. Results showed that the identified VOCs are associated with inflammatory responses or pulmonary diseases and most subjects reported pulmonary symptoms reflecting early-stage POT. Therefore, these VOCs are likely markers of POT, not just indicators of hyperbaric hyperoxic exposure.
Article
Biochemistry & Molecular Biology
Mario Martin-Almeida, Javier Perez-Garcia, Esther Herrera-Luis, Carlos Rosa-Baez, Mario Gorenjak, Anne H. Neerincx, Olaia Sardon-Prado, Antoaneta A. Toncheva, Susanne Harner, Christine Wolff, Susanne Brandstetter, Elisa Valletta, Mahmoud Abdel-Aziz, Simone Hashimoto, Vojko Berce, Paula Corcuera-Elosegui, Javier Korta-Murua, Heike Buntrock-Doepke, Susanne J. H. Vijverberg, Joris C. Verster, Nikki Kerssemakers, Anna M. Hedman, Catarina Almqvist, Jesus Villar, Aletta D. Kraneveld, Uros Potocnik, Michael Kabesch, Anke H. Maitland-van der Zee, Maria Pino-Yanes
Summary: Asthma is a common chronic disease in children, but the influence of DNA methylation on bronchodilator drug response and fractional exhaled nitric oxide is understudied. In this study, we identified DNA methylation markers associated with fractional exhaled nitric oxide in blood samples and bronchodilator drug response in pediatric asthma patients.
Article
Allergy
Korneliusz Golebski, Rik Johannes Leonardus van Der Lans, Danielle van Egmond, Esther de Groot, Hergen Spits, Anke-Hilse Maitland-van Der Zee, Cornelis Maria van Drunen, Wytske Johanna Fokkens, Sietze Reitsma
Article
Health Care Sciences & Services
Nadia Baalbaki, Jelle M. Blankestijn, Mahmoud I. Abdel-Aziz, Jan de Backer, Somayeh Bazdar, Ines Beekers, Rosanne J. H. C. G. Beijers, Joop P. van den Bergh, Lizan D. Bloemsma, Harm Jan Bogaard, Job J. M. H. van Bragt, Vera van den Brink, Jean Paul Charbonnier, Merel E. B. Cornelissen, Yennece Dagelet, Elin Haf Davies, Anne M. van der Does, George S. Downward, Cornelis M. van Drunen, Debbie Gach, J. J. Miranda Geelhoed, Jorrit Glastra, Kornel Golebski, Irene H. Heijink, Judith C. S. Holtjer, Sebastiaan Holverda, Laura Houweling, John J. L. Jacobs, Renee Jonker, Renate Kos, Ramon C. J. Langen, Ivo van der Lee, Asabi Leliveld, Firdaus A. A. Mohamed Hoesein, Anne H. Neerincx, Lieke Noij, Johan Olsson, Marianne van de Pol, Simon D. Pouwels, Emiel Rolink, Michael Rutgers, Havva Sahin, Daphne Schaminee, Annemie M. W. J. Schols, Lisanne Schuurman, Gitte Slingers, Olie Smeenk, Brigitte Sondermeijer, Paul J. Skipp, Marisca Tamarit, Inge Verkouter, Roel Vermeulen, Rianne de Vries, Els J. M. Weersink, Marco van de Werken, Yolanda de Wit-van Wijck, Stewart Young, Esther J. Nossent, Anke H. van der Zee
Summary: The P4O2 COVID-19 study aims to identify long COVID patients at risk for developing chronic lung disease and to find personalized therapeutic strategies. The study showed persistent symptoms and abnormalities in post-COVID patients, with the most commonly reported symptoms being respiratory and neurological symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Respiratory System
Elisangela Santos-Valente, Heike Buntrock-Dopke, Rola Abou Taam, Stefania Arasi, Arzu Bakirtas, Jaime Lozano Blasco, Klaus Bonnelykke, Mihai Craiu, Renato Cutrera, Antoine Deschildre, Basil Elnazir, Louise Fleming, Urs Frey, Monika Gappa, Antonio Nieto Garcia, Kirsten Skamstrup Hansen, Laurence Hanssens, Karina Jahnz-Rozyk, Milos Jesenak, Sebastian Kerzel, Matthias Kopp, Gerard H. Koppelman, Uros Krivec, Kenneth A. MacLeod, Mika Makela, Erik Melen, Gyorgyi Mezei, Alexander Moeller, Andre Moreira, Petr Pohunek, Predrag Minic, Niels W. P. Rutjes, Patrick Sammut, Nicolaus Schwerk, Zsolt Szepfalusi, Mirjana Turkalj, Iren Tzotcheva, Alexandru Ulmeanu, Stijn Verhulst, Paraskevi Xepapadaki, Jakob Niggel, Susanne Vijverberg, Anke H. Maitland-van der Zee, Uros Potocnik, Susanne M. Reinartz, Cornelis M. van Drunen, Michael Kabesch
Summary: The survey on biological therapy of childhood asthma in Europe revealed substantial differences in management across countries, indicating a need for further studies on biomarkers supporting selection of biologicals, criteria to assess therapy response, and how/when to end therapy in stable patients.
Article
Medicine, General & Internal
Charles F. Hayfron-Benjamin, Charlotte Mosterd, Anke H. Maitland-van der Zee, Daniel H. van Raalte, Albert G. B. Amoah, Charles Agyemang, Bert-Jan van den Born
Summary: This study found unequal associations between inflammatory biomarkers and vascular dysfunction in different ethnic groups, providing valuable insights for future research.