Article
Clinical Neurology
Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Compared to adolescents with antidepressant-responsive depression, those with antidepressant-resistant depression have a higher risk of developing type 2 diabetes mellitus. Clinicians should closely monitor risk factors related to type 2 diabetes in high-risk populations, especially in adolescents with antidepressant-resistant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Chi-Shin Wu, Le-Yin Hsu, Yi-Jiun Pan, Shi-Heng Wang
Summary: This nationwide retrospective cohort study found that regular antidepressant use was associated with lower risk of advanced diabetic complications and mortality in patients with depression and diabetes mellitus, compared to poor adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Kayla Teopiz, Bing Cao, Yena Lee, Hartej Gill, Roger Ho, Kangguang Lin, Nelson B. Rodrigues, Michelle Iacobucci, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: The study revealed that insulin resistance affects the efficacy of the antidepressant vortioxetine in patients with Major Depressive Disorder. Higher baseline insulin resistance predicted decreased early improvements in depressive symptoms and worsening cognitive function and functional impairment at the end of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Jay A. Brieler, Joanne Salas, Elizabeth Keegan-Garrett, Jeffrey F. Scherrer
Summary: This study investigated the association between acute phase antidepressant medication treatment and glycemic control in patients with type 2 diabetes. The results showed that acute phase treatment was significantly associated with achieving glycemic control within 36 months, but not beyond 36 months. There was no association between acute vs. less than acute phase treatment and glycemic control.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Masa Cater, Sabine M. Hoelter
Summary: Diabetes is strongly linked to neurodegenerative disorders, especially Alzheimer's disease, and insulin resistance has been proven to be connected to cognitive decline and dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rosanne J. J. Turner, Karin Hagoort, Rosa J. J. Meijer, Femke Coenen, Floortje E. E. Scheepers
Summary: Currently, it is challenging to choose the right antidepressant for individual patients. In this study, we used retrospective Bayesian network analysis and natural language processing to identify patterns in patient characteristics, treatment choices, and outcomes. We collected data from adult patients treated with antidepressants at two mental healthcare facilities in the Netherlands between 2014 and 2020. By analyzing clinical notes, we extracted outcome measures such as antidepressant continuation, prescription duration, and treatment outcome topics. Our findings revealed dependencies between treatment choices, patient characteristics, and outcomes. Tightly intertwined with treatment outcomes and prescription duration were the use of antipsychotics and benzodiazepines. Tricyclic antidepressant prescription and depressive disorder were significant predictors for antidepressant continuation. This study offers a feasible approach for pattern discovery in psychiatry data, and further research should explore the potential translation of these patterns into clinical decision support tools.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Wanxu Guo, Xiaoxiao Yao, Ranji Cui, Wei Yang, Lei Wang
Summary: This review outlines the antidepressant effect and mechanism of action of Paeoniflorin (PF), including increasing monoamine neurotransmitter levels, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating brain-derived neurotrophic factor (BDNF) levels. The potential application of PF in the treatment of depression is discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Maria Lucia da Silva Cordeiro, Veronica Giuliani de Queiroz Aquino Martins, Ariana Pereira da Silva, Hugo Alexandre Oliveira Rocha, Vanessa de Paula Soares Rachetti, Katia Castanho Scortecci
Summary: This article introduces depression and the limitations of pharmacological treatment. The study suggests that phenolic acids from medicinal plants and their extracts have the potential to reduce depressive symptoms and modulate multiple molecular pathways associated with depression.
Article
Biochemistry & Molecular Biology
Rui Zhang, Caili Qiao, Qiuyan Liu, Jingwen He, Yifan Lai, Jing Shang, Hui Zhong
Summary: The study suggests that using zebrafish models in screening for antidepressants can replace rodents, with similarities in behavior and pathology. This could help shorten the drug screening cycle and achieve high-throughput screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Li-Tao Yi, Man-Man Zhang, Jie Cheng, Hui-Qi Wan, Cheng-Fu Li, Ji-Xiao Zhu, Qiu-Ping Zhang, Qing Liu, Guang-Hui Xu
Summary: Degraded porphyran extracted from Porphyra haitanensis has shown potential antidepressant effects by inhibiting neuroinflammation and enhancing neurogenesis in the central nervous system.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Psychiatry
Hyewon Kim, You-Bin Lee, Jungkuk Lee, Dongwoo Kang, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Kyu Yeon Hur, Hong Jin Jeon
Summary: The study found that individuals with depression have a reduced risk of developing type 2 diabetes. However, this risk varies depending on the age at onset, comorbidity, and type of antidepressants used.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Philip Boyce, Rebecca Anglin, Elizabeth McKinnon, Andrew J. Lewis
Summary: The study found that women with untreated depression during pregnancy had higher intake of unhealthy takeaway food throughout the postpartum period, while higher depressive symptoms in the postpartum were also associated with higher takeaway intake. However, there was no difference in fruit and vegetable intake among the three groups, and intake was highest for all women late in pregnancy and declined in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Elif Tunc-Ozcan, Sarah M. Brooker, Jacqueline A. Bonds, Yung-Hsu Tsai, Radhika Rawat, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler
Summary: Hippocampal BMP signaling is identified as a common pathway mediating the behavioral effects of multiple antidepressant classes and electroconvulsive therapy. Inhibition of hippocampal BMP signaling is shown to be both necessary and sufficient to mediate the effects of these treatments, involving a key role in neurogenesis in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Anastasiya Zaytseva, Evelina Bouckova, McKennon J. Wiles, Madison H. Wustrau, Isabella G. Schmidt, Hadassah Mendez-Vazquez, Latika Khatri, Seonil Kim
Summary: Ketamine enhances neuronal activity and synaptic strength by reducing calcineurin activity, leading to rapid antidepressant effects.
Article
Oncology
Eward J. Melis, Jeannette E. F. Zwart-van Rijkom, Toine C. G. Egberts, Bart J. F. van den Bemt, Petronella O. Witteveen, Helga Gardarsdottir
Summary: This study assesses the association between patient satisfaction with information about oral anticancer agents and adherence. The results showed no significant relationship between patient satisfaction with information and adherence, despite the high level of satisfaction with the information. However, 35.5% of patients were found to be non-adherent based on refill data.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Geriatrics & Gerontology
Lotte Gerritsen, Sigurdur Sigurdsson, Palmi Jonsson, Vilmundur Gudnason, Lenore J. Launer, Mirjam Geerlings
Summary: Late-life depression (LLD) may increase the risk of dementia, with severe LLD, mild LLD, and apathy being the main symptoms associated with higher risk. The increase in white matter lesions over time may partially mediate the relationship between mild LLD and dementia.
NEUROBIOLOGY OF AGING
(2022)
Article
Pharmacology & Pharmacy
Carline J. van den Dries, Romin Pajouheshnia, Hendrika A. van den Ham, Patrick Souverein, Karel G. M. Moons, Arno W. Hoes, Geert-Jan Geersing, Sander van Doorn
Summary: This study investigates the effects of off-label non-vitamin K oral anticoagulant (NOAC) dose reduction compared with on-label standard dosing in atrial fibrillation (AF) patients. The results show that there is no significant difference in the risk of ischemic stroke and major bleeding between patients receiving off-label reduced NOAC dose and those receiving on-label standard dose, while the risk of non-major bleeding is lower and the risk of mortality is higher in the off-label group.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Editorial Material
Clinical Neurology
Rashid Ghaznawi, Ina Rissanen, Jeroen de Bresser, Hugo J. Kuijf, Nicolaas P. A. Zuithoff, Jeroen Hendrikse, Mirjam Geerlings
Summary: This study examined the association between carotid artery stenosis (CAS) and progression of hemispheric brain atrophy. The results showed that severe CAS on the right side was associated with a greater decrease in volume of both the left and right hemispheres, while increasing degrees of CAS on the left side were not associated with greater volume loss.
CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter B. van Dijk, Ewoud Schuit, Rieke van der Graaf, Rolf H. H. Groenwold, Sara Laurijssen, Barbara Casadei, Marco Roffi, Seye Abimbola, Martine C. de Vries, Diederick E. Grobbee
Summary: This study evaluated the feasibility of implementing ESC guidelines on general cardiology in 102 countries and found that compliance varied based on the country's income level. High-income countries had better compliance, while low-income countries had lower compliance, largely due to lack of reimbursement and financial barriers.
EUROPEAN HEART JOURNAL
(2023)
Article
Neurosciences
Emma L. Twait, Kim Blom, Huiberdina L. Koek, Maarten H. T. Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I. Geerlings
Summary: This study used high-field 7T MRI to explore the association between psychosocial factors and hippocampal (subfield) volumes. The results showed that depression and anxiety were not associated with specific hippocampal (subfield) volumes, while childhood maltreatment and recent stressful life events may have an impact on hippocampal volume. Additionally, low social support was associated with smaller CA3 volume.
HUMAN BRAIN MAPPING
(2023)
Review
Computer Science, Information Systems
Britt W. M. van de Burgt, Arthur T. M. Wasylewicz, Bjorn Dullemond, Rene J. E. Grouls, Toine C. G. Egberts, Arthur Bouwman, Erik M. M. Korsten
Summary: This review examines the use of text mining and clinical decision support in clinical practice, discussing their potential benefits, implementation challenges, and barriers. The findings suggest that combining text mining and clinical decision support can improve diagnostic and therapeutic processes, leading to increased patient safety. However, there are still barriers to implementation that need to be addressed through further research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Genetics & Heredity
Corine de Jong, Gerarda J. M. Herder, Simone W. A. van Haarlem, Femke S. van der Meer, Anne S. R. van Lindert, Alexandra ten Heuvel, Jan Brouwer, Toine C. G. Egberts, Vera H. M. Deneer
Summary: This study investigated the genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN) in non-small cell lung cancer (NSCLC) patients. It revealed that the GG genotype of TRPV1 gene (rs879207) is associated with an increased risk of severe neuropathy. Additionally, concomitant use of paclitaxel and GG genotype also showed a significant association with severe CIPN.
Article
Biophysics
T. (Tim) Bognar, J. S. (Jurjen) Kingma, E. H. (Erin) Smeijsters, K. C. M. (Kim) van der Elst, C. T. M. (Klaartje) de Kanter, C. A. (Caroline) Lindemans, A. C. G. (Toine) Egberts, I. H. (Imke) Bartelink, A. (Arief) Lalmohamed
Summary: This observational study assessed the impact of therapeutic drug monitoring on busulfan exposure in pediatric patients undergoing hematopoietic cell transplantation. The results showed no significant difference in achieving therapeutic busulfan exposure between the two monitoring regimens, suggesting that day 1-guided dosing may be sufficient with subsequent monitoring if needed.
BONE MARROW TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Nicholas B. Hunt, Romin Pajouheshnia, Allan Salih, Sander van Doorn, Patrick C. Souverein, Marloes T. Bazelier, Olaf H. Klungel, Helga Gardarsdottir
Summary: This study aimed to describe the prescription trends of low-dose rivaroxaban in ASCVD patients and compare the trends before and after guideline changes in two European countries. The results showed a significant increase in the use of low-dose rivaroxaban in the management of ASCVD after guideline changes in the UK and the Netherlands, but it has not been widely adopted.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Marjon V. Verschueren, Talitha Dijs, Judith L. Gulikers, Ard van Veelen, Sander Croes, Lizza E. L. Hendriks, Adrianus A. J. Smit, Lourens T. Bloem, Antoine C. G. Egberts, Ewoudt M. W. van de Garde, Bas J. M. Peters
Summary: Real-world stage III NSCLC patients who received durvalumab after CRT had better outcomes than those who received CRT alone. Longer PFS in real-world versus trial may be due to follow-up differences.
Article
Genetics & Heredity
Marleen E. Jansen, Tessel Rigter, Thom M. C. Fleur, Patrick C. Souverein, W. M. Monique Verschuren, Susanne J. Vijverberg, Jesse J. Swen, Wendy Rodenburg, Martina C. Cornel
Summary: Pharmacogenomic testing is used to prevent adverse drug reactions, particularly in statin treatment. This study aimed to investigate the usefulness of pre-emptive pharmacogenomic screening in primary care, focusing on the SLCO1B1 c.521T>C genotype as a risk factor for adverse drug reactions. However, the study did not find an association between the SLCO1B1 c.521T>C genotype and changes in statin therapy in primary care. Prospective data collection is needed to better evaluate the predictive value of the SLCO1B1 c.521T>C genotype on adverse drug reactions.
Review
Cardiac & Cardiovascular Systems
Salisu Mohammed Ishaku, Kwame Adu-bonsaffoh, Natasha Housseine, Roberta Lamptey, Arie Franx, Diederick Grobbee, Charlotte E. Warren, Joyce L. Browne
Summary: This article aims to generate consensus-based recommendations for the prevention and screening of cardiometabolic and kidney diseases following hypertensive disorders in pregnancy (HDP) in low- and middle-income countries (LMICs). The recommendations provide practical and scalable approaches for effective screening and prevention of cardiometabolic disease following HDP in LMICs. Monitoring and evaluation of implementation of these recommendations provide opportunities for reducing the escalating burden of noncommunicable diseases in LMICs.
Article
Hematology
Anouk A. M. T. Donners, Konrad van der Zwet, Carin M. A. Rademaker, Toine C. G. Egberts, Roger E. G. Schutgens, Kathelijn Fischer
Summary: This study evaluated the efficacy of entire-vial dosing of emicizumab in a real-world setting. The results demonstrated that this dosing method can achieve therapeutic plasma concentrations, effectively control bleeding, and reduce drug waste.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter B. van Dijk, Artuur M. Leeuwenberg, Diederick E. Grobbee, Sabrina Siregar, Saskia Houterman, Edgar J. Daeter, Martine C. de Vries, Rolf H. H. Groenwold, Ewoud Schuit
Summary: A study in the Netherlands revealed that the EuroSCORE II model has good discriminative performance but consistently overestimates mortality risks in all types of major cardiothoracic surgical procedures. The values of individual predictors varied widely over time.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
