Article
Economics
Kamilla Koszoru, Krisztina Hajdu, Valentin Brodszky, Alex Bato, L. Hunor Gergely, Aniko Kovacs, Zsuzsanna Beretzky, Miklos Sardy, Andrea Szegedi, Fanni Rencz
Summary: In adult patients with AD, EQ-5D-5L demonstrated superiority over EQ-5D-3L in terms of ceiling effects, informativity, and convergent validity. Therefore, we recommend the use of EQ-5D-5L to measure health outcomes in clinical settings and for QALY calculations in AD.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Economics
Ben A. van Hout, James W. Shaw
Summary: This research developed algorithms to map EQ-5D-3L responses to EQ-5D-5L value sets and found that including indicants of problems for other dimensions as regressors in the model improved prediction accuracy. Adding age and gender lowered AIC without improving predictions, while including a latent factor slightly improved predictive accuracy. Models conditioning on problems in other dimensions yielded more accurate predictions than an alternative copula-based approach.
Article
Multidisciplinary Sciences
Chun-Hsiang Yu, Sheng-Mao Chang, Chih-Hui Hsu, Sheng-Han Tsai, Xin-Min Liao, Chang-Wei Chen, Ching-Hsiung Lin, Jung-Der Wang, Tzuen-Ren Hsiue, Chiung-Zuei Chen
Summary: This study predicts the utility of the European Quality of Life-5 Dimensions (EQ-5D-3L) questionnaire from the chronic obstructive pulmonary disease (COPD) assessment test (CAT) using a multinomial logistic regression (MLR) model and response mapping. The MLR model performs as well as other models in terms of prediction accuracy. Bubble chart analysis suggests that the model developed in this study and the Mean Rank Method (MRM) may be better predictive models.
SCIENTIFIC REPORTS
(2022)
Article
Management
Mosleh Amiri, Hamid Farvaresh
Summary: This paper addresses a problem in collaborative logistics related to the formation of a coalition by carriers with transferable and non-transferable utilities. Mathematical models are proposed to formulate cooperation and non-cooperation as multi-objective optimization problems, where carriers aim to maximize profit and increase customer coverage. Conditions to define a generalized core solution concept and a generalized form of the Shapley value are developed to allocate the coalition outcomes. Two methods for reaching a compromise among coalition members are proposed, and heuristic and full-enumeration methods are developed to find Pareto-optimal solutions. Computational results demonstrate the effectiveness of cooperation in improving profit without compromising customer coverage.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Nikolaos Kontodimopoulos, Eleni Stamatopoulou, Sousana Gazi, Dimitra Moschou, Michail Krikelis, Michael A. Talias
Summary: This study compared the utilities of EQ-5D-3L, EQ-5D-5L, and SF-6D in patients with different musculoskeletal disorders, and classified them according to disease severity. The results showed higher agreement between EQ-5D-5L and SF-6D, compared to EQ-5D-3L and SF-6D. These discrepancies could have implications on economic evaluations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Nasrin Moradi, Thomas G. Poder, Hossein Safari, Mohammad M. Mojahedian, Hosein Ameri
Summary: This study aimed to test the validity and reliability of the EQ-5D-5L (5L) in cancer patients compared to EQ-5D-3L (3L). The results showed that compared to 3L, 5L performed better in terms of ceiling effect, inconsistency, discriminatory power, convergent validity, and relative efficiency.
FRONTIERS IN ONCOLOGY
(2022)
Article
Economics
Fanni Rencz, Valentin Brodszky, Mathieu F. Janssen
Summary: This study compares measurement properties of EQ-5D-5L, PROMIS-29+2, and PROMIS-GH-10, and provides comparative evidence for the choice of instruments in population health surveys and cost-utility analyses. Results show that most PROMIS items have enhanced distributional characteristics and good convergent validity with EQ-5D-5L. EQ-5D-5L utilities are higher than PROPr utilities.
Article
Economics
Chen-Wei Pan, Jun-Yi He, Yan-Bo Zhu, Chun-Hua Zhao, Nan Luo, Pei Wang
Summary: Utility scores derived from country-specific value sets of EQ-5D-5L and EORTC QLU-C10D in gastric cancer patients showed similar convergent and known-group validity, but EQ-5D-5L scores may have better discriminative power.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Economics
Takeru Shiroiwa, Shinichi Noto, Takashi Fukuda
Summary: This study established the Japanese population norms of the EQ-5D-5L and HUI3, revealing that values of both instruments are significantly influenced by age, sex, household income, and education level. The study also found that Parkinson's disease, dementia, and stroke were associated with the highest disutility, while depression had a relatively lower disutility.
Article
Multidisciplinary Sciences
Cesar Fernandez-de-las-Penas, Jorge Rodriguez-Jimenez, Paloma Moro-Lopez-Menchero, Ignacio Cancela-Cilleruelo, Alberto Pardo-Hernandez, Valentin Hernandez-Barrera, Angel Gil-de-Miguel
Summary: The study aimed to evaluate the psychometric properties of the EQ-5D-5L scale in COVID-19 survivors. The results showed good internal consistency, test-retest reliability, and construct validity of the scale, making it suitable for assessing health-related quality of life in long-COVID patients.
SCIENTIFIC REPORTS
(2022)
Article
Economics
Mihir Gandhi, Ru San Tan, Shir Lynn Lim, Kim Rand, Carolyn S. P. Lam, Nan Luo, Yin Bun Cheung
Summary: This study aimed to investigate the health preferences of patients with heart disease and develop a value set for the 5-level EQ-5D (EQ-5D-5L) based on these patient preferences. The value set could be used for patient-centric economic evaluation and health-related quality of life assessment for patients with heart disease.
Article
Health Care Sciences & Services
Alex Bato, Valentin Brodszky, L. Hunor Gergely, Krisztian Gaspar, Norbert Wikonkal, Agnes Kinyo, Akos Szabo, Zsuzsanna Beretzky, Andrea Szegedi, Eva Remenyik, Norbert Kiss, Miklos Sardy, Fanni Rencz
Summary: The study aimed to compare the measurement properties of two adult versions of EQ-5D in patients with Hidradenitis suppurativa (HS), with EQ-5D-5L outperforming EQ-5D-3L in terms of feasibility, informativity, and validity for important clinical characteristics. EQ-5D-5L was recommended for assessing HS patients across various settings.
QUALITY OF LIFE RESEARCH
(2021)
Article
Economics
Svenja Elkenkamp, Kristina Ludwig, Wolfgang Greiner
Summary: This research aimed to determine the robustness of the German EQ-5D-5L valuation data for the general population compared with those with health impairments. The results showed that people with self-reported health impairments do not have different EQ-5D-5L health state preferences compared with the German general population.
Article
Economics
Andrea L. Monteiro, Maja Kuharic, A. Simon Pickard
Summary: The EQ Health and Wellbeing Short (EQ-HWB-S) is a new measure of health and wellbeing that overlaps with, and expands upon, the EQ-5D-5L. The study found moderate to strong associations between the two measures and concluded that the EQ-HWB-S performs similarly or better than the EQ-5D-5L among patient groups, particularly in distinguishing caregivers and those closer to full health.
Article
Health Care Sciences & Services
Jie Jiang, Yanming Hong, Tiantian Zhang, Zhihao Yang, Tengfei Lin, Zhuoru Liang, Peiyao Lu, Lishun Liu, Binyan Wang, Yongmei Xu, Nan Luo
Summary: This study compared the measurement properties of EQ-5D-3L and EQ-5D-5L in hypertensive patients in rural China. The results showed that the 5L version had a lower ceiling effect and higher informativity compared to the 3L version, with good agreement between the two.
QUALITY OF LIFE RESEARCH
(2021)
Article
Economics
Jalal Dahham, Ingrid Kremer, Mickael Hiligsmann, Kamal Hamdan, Abdallah Nassereddine, Silvia M. A. A. Evers, Rana Rizk
Summary: This paper discusses the steps taken to overcome price fluctuations in cost valuation during times of financial and economic crisis and provides empirical recommendations on cost valuation that are particularly relevant in low- and middle-income countries (LMICs).
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Medicine, General & Internal
Lena Schnitzler, Aggie T. G. Paulus, Tracy E. Roberts, Silvia M. A. A. Evers, Louise J. Jackson
Summary: The objective of this study was to explore the intersectoral costs and benefits associated with sexual health issues and interventions, categorize them into sectors, and develop a preliminary framework for future research and policy-making. The study found that sexual health issues have wide-ranging impacts on other health sectors and non-health sectors. Therefore, these different sectors need to be considered when evaluating interventions and making policy decisions.
Article
Health Care Sciences & Services
I Pokhilenko, T. Kast, L. M. M. Janssen, S. M. A. A. Evers, A. T. G. Paulus, J. Simon, S. Mayer, M. Berger, A. Konnopka, L. Muntendorf, V Brodszky, L. Garcia-Perez, A. Park, L. Salvador-Carulla, R. M. W. A. Drost
Summary: In this study, a standardized unit cost calculation tool developed in the PECUNIA project was applied to calculate the reference unit costs (RUCs) of selected education services in five European countries. The RUCs of special education services and educational therapy were calculated using information collected via literature search and contact with service providers. There was variation in the RUCs across countries, highlighting the need for further research and efforts to improve data quality.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Economics
Irina Pokhilenko, Luca M. M. Janssen, Aggie T. G. Paulus, Ruben M. W. A. Drost, William Hollingworth, Joanna C. Thorn, Sian Noble, Judit Simon, Claudia Fischer, Susanne Mayer, Luis Salvador-Carulla, Alexander Konnopka, Leona Hakkaart van Roijen, Valentin Brodszky, A-La Park, Silvia M. A. A. Evers
Summary: This study provides a detailed description of the practical application of a stepwise approach to the development of a multi-sectoral Resource Use Measurement (RUM) instrument. It highlights the need for additional steps to ensure a uniform methodological basis, harmonization of questionnaire modules, and involvement of a broader range of stakeholders due to the complexity of developing a multi-sectoral RUM instrument.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Medicine, Research & Experimental
Sander L. Osstyn, Ron Handels, Lizzy M. M. Boots, Sanne C. E. Balvert, Silvia M. A. A. Evers, Marjolein E. de Vugt
Summary: This paper presents the design of a study evaluating the effectiveness, cost-effectiveness, and cost-utility of a blended self-management program for early-stage dementia caregivers. The study will be a pragmatic, cluster randomized controlled trial with a shared control group. The primary outcome for effectiveness is care management self-efficacy.
Review
Cardiac & Cardiovascular Systems
Isabell Wiethoff, Birgit Goversen, Michelle Michels, Jolanda van der Velden, Mickael Hiligsmann, Tom Kugener, Silvia M. A. A. Evers
Summary: This study systematically identified and reviewed cost-of-illness (COI) studies and economic evaluations (EEs) of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). The results showed that these inherited heart conditions have a significant societal and economic burden, but current knowledge is limited. Future research should consider a broader range of costs to optimize care for affected patients.
NETHERLANDS HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Isabell Wiethoff, Silvia M. A. A. Evers, Michelle Michels, Mickael Hiligsmann
Summary: Cardiovascular diseases impose a significant burden on patients and society. The Netherlands is increasingly using health technology assessment (HTA) to inform policy bodies and guide decision-making on healthcare funding. This paper aims to define HTA, discuss its relevance to healthcare policy, and provide an overview of economic evaluation methodology targeting health professionals and researchers with limited prior knowledge.
NETHERLANDS HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ute Linnenkamp, Veronika Gontscharuk, Katherine Ogurtsova, Manuela Bruene, Nadezda Chernyak, Tatjana Kvitkina, Werner Arend, Imke Schmitz-Losem, Johannes Kruse, Norbert Hermanns, Bernd Kulzer, Silvia M. A. A. Evers, Mickael Hiligsmann, Barbara Hoffmann, Andrea Icks, Silke Andrich
Summary: This study examined how different instruments identify depression among patients with diabetes and found that the choice of method is related to specific characteristics such as gender, antidepressant use, and previous depression.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Medicine, General & Internal
Ruud Droeghaag, Valerie N. E. Schuermans, Sem M. M. Hermans, Anouk Y. J. M. Smeets, Inge J. M. H. Caelers, Mickael Hiligsmann, Silvia Evers, Wouter L. W. van Hemert, Henk van Santbrink
Summary: This systematic review aims to evaluate the methodology and quality of clinical cost-effectiveness studies in spine surgery. The study found that there is a lack of comparability among existing economic evaluations in spine surgery, highlighting the need for uniformity in conducting and reporting such evaluations.
Article
Critical Care Medicine
N. A. C. van den Boom, A. A. van den Hurk, S. M. A. A. Evers, M. Poeze
Summary: The aim of this study was to measure the societal burden and quality of life in patients with Lisfranc fractures in the Netherlands. The study found that the total societal costs in the first 6 months after injury are approximately euro17,083, with approximately two thirds attributed to productivity losses. The study also found an improvement in quality of life after treatment and a long-lasting impact on quality of life.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Psychiatry
Ben Wijnen, Maud Jansen, Annelieke van Velthoven, Imke Hanssen, Marloes Huijbers, Silvia Evers, Anne Speckens
Summary: The cost-effectiveness and cost-utility of mindfulness-based cognitive therapy (MBCT) and treatment as usual (TAU) were assessed in adults with Bipolar disorder (BD) compared to TAU alone. The study found that MBCT + TAU had lower total costs and only significant differences in healthcare costs compared to TAU. Furthermore, MBCT + TAU showed small differences in QALYs and costs, resulting in a dominant incremental cost-utility ratio. Sensitivity analyses confirmed the robustness of the base case analyses.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Isabell Wiethoff, Maurits Sikking, Silvia Evers, Andrea Gabrio, Michiel Henkens, Michelle Michels, Job Verdonschot, Stephane Heymans, Mickael Hiligsmann
Summary: Dilated cardiomyopathy (DCM) is a major cause of heart failure, leading to low quality of life and high societal costs for patients, especially those with severe symptoms.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Psychology, Multidisciplinary
Brigitte Essers, Pei Wang, Elly Stolk, Marcel F. Jonker, Silvia Evers, Manuela Joore, Carmen Dirksen
Summary: The study aimed to explore the age dependency of health state values derived from trade-offs between HRQoL and life years, and found differences in consistency of health state values for different age groups between the Netherlands and China, as well as no clear patterns in the composition of QALYs.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Lena Schnitzler, Aggie T. G. Paulus, Silvia M. A. A. Evers, Tracy E. Roberts, Louise J. Jackson
Summary: The study sought experts' views on the development of a checklist for cost-of-illness (COI) studies. Interviews with 21 experts from 11 countries confirmed the relevance of COI studies in estimating disease burden, identifying cost components, guiding decision making, and providing input for economic evaluations. A lack of standardized critical appraisal tools for COI studies was mentioned, with experts primarily relying on guidelines and checklists for full economic evaluations. Themes discussed during the interviews included the need for a critical appraisal tool, format and practicality, assessing questions, addressing subjectivity, and guidance requirements.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2023)
Article
Health Care Sciences & Services
Damon Willems, Eva-Lotta Hinzpeter, Hessel H. Van der Zee, Christopher J. Sayed, John R. Ingram, Charlotte Beaudart, Silvia M. A. A. Evers, Mickael Hiligsmann
Summary: This study investigated the treatment preferences of adult patients with HS in Europe. The results revealed that effectiveness was the most important attribute, followed by pain reduction, risk of mild adverse events, risk of serious infection, mode of administration, and duration of treatment benefit. Future HS treatments should be designed to offer higher levels of effectiveness and pain improvement without increasing the risk of adverse events.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)