Article
Biochemistry & Molecular Biology
Xin Li, Mengyi Zhu, Min Zang, Dandan Cao, Zhengyao Xie, Haibo Liang, Zexin Bian, Tingting Zhao, Zhibin Hu, Eugene Yujun Xu
Summary: The study highlights the essential role of PUM1 in regulating cell cycle progression in ovarian somatic cells, which is crucial for follicular development and female fertility. PUM1 targets key cell cycle regulators and its loss leads to reduced granulosa cell proliferation, affecting follicular growth and fertility. This translational control mechanism mediated by PUM1 is implicated in mammalian female reproduction and may have implications in human cancer biology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Oncology
Jinbowen Yan, Fangzhi Xu, Dan Zhou, Shuo Zhang, Bo Zhang, Qingwei Meng, Qiubo Lv
Summary: Metabolic reprogramming is the alteration of metabolic pathways in cancer cells to support their growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle, leading to the production of metabolic intermediates for cellular component biosynthesis and energy homeostasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Changhao Wu, Chenglong Zheng, Shiyu Chen, Zhiwei He, Hao Hua, Chengyi Sun, Chao Yu
Summary: Pancreatic cancer (PC) is a gastrointestinal tract malignant tumor with a poor prognosis. FOXQ1 has been found to be overexpressed in PC tissues and associated with poor prognosis. FOXQ1 overexpression promotes PC cell proliferation, tumor stemness, invasion, and metastasis, while FOXQ1 silencing shows the reverse effect. Mechanistic studies reveal that FOXQ1 promotes LDHA transcription to enhance aerobic glycolysis, contributing to the progression of PC.
CELL DEATH & DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Linjia Su, Zhe Sun, Fangzheng Qi, Huishan Su, Luomeng Qian, Jing Li, Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li, Zhinan Chen, Sihe Zhang
Summary: This study highlights the use of Tat/pDNA-Ca2+ nanoparticles for tumor-targeted suicide gene therapy. These nanoparticles show improved delivery efficiency and utilize macropinocytosis for intercellular delivery. The mitochondrial chaperone GRP75 plays a dual role in cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles. The targeting of GRP75 combined with cell-cycle or macropinocytosis inhibitors demonstrates distinct suicide gene therapy efficiency.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yannick Audet-Delage, Michele Rouleau, Lyne Villeneuve, Chantal Guillemette
Summary: Nucleotide sugar-dependent glycosyltransferases (UGTs) play critical roles in cellular metabolism, and this study reveals the impact of UGT expression on cellular metabolism. The expression of UGTs leads to modifications in multiple biochemical pathways, affecting glycolysis, pyrimidine pathways, and precursors of UDP-glucuronic acid metabolism. Furthermore, alternative splicing-derived isoforms of UGTs induce unique metabolic perturbations and extensive connectivity with other metabolic processes.
Article
Oncology
Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini, Claudio Stefanelli, Romana Fato, Laura Gramantieri, Francesca Fornari
Summary: This study aims to prove the involvement of miR-494 in the metabolic reprogramming of HCC, identify novel therapeutic combinations, and evaluate miR-494 potential as a circulating biomarker. The results showed that miR-494 induced metabolic shift in HCC cells, leading to cell survival under harsh conditions and sorafenib resistance. MiR-494 could be a potential biomarker for predicting the response to sorafenib treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Sarah A. Best, Patrick M. Gubser, Shalini Sethumadhavan, Ariena Kersbergen, Yashira L. Negron Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L. Garnham, Jackson A. McDonald, Clare E. Weeden, Dovile Anderson, David Pirman, Thomas P. Roddy, Darren J. Creek, Axel Kallies, Gillian Kingsbury, Kate D. Sutherland
Summary: The tumor microenvironment in KRAS-mutant lung adenocarcinoma plays a crucial role in the activation of CD8 T cells, and the inhibition of glutaminase negatively impacts CD8 T cells activated by anti-PD1 immunotherapy.
Article
Biochemical Research Methods
Mallory I. Frederick, Owen F. J. Hovey, Jenica H. Kakadia, Trevor G. Shepherd, Shawn S. C. Li, Ilka U. Heinemann
Summary: This study investigated the cellular signaling dynamics during epithelial ovarian cancer (EOC) metastasis using cellular models. The results showed that spheroid cells in the metastatic process exhibited hypoxia and cell cycle arrest, and stimulated Rho-associated kinase 1 (ROCK1)-mediated signaling related to cytoskeletal organization. Aurora kinase B and ROCK1 were identified as major drivers of metastatic behavior in EOC cells.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Oncology
Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Vivek Anand, Bin Yuan, Fouad El-Dana, Yuanqing Yan, Zoe Arvanitis, Danthasinghe Waduge Badrajee Piyarathna, Nagireddy Putluri, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, V. Lokesh Battula
Summary: This study demonstrates that metabolic stress induces the GD2(+) BCSC phenotype in triple-negative breast cancer (TNBC) and highlights the role of glutamine in this phenotype. Inhibiting glutamine transporters can reduce BCSC characteristics in TNBC cells, suggesting a potential complementary approach to conventional chemotherapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Zied Boudhraa, Kossay Zaoui, Hubert Fleury, Maxime Cahuzac, Sophie Gilbert, Guergana Tchakarska, Jennifer Kendall-Dupont, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson
Summary: The study demonstrates a new approach to target epithelial ovarian cancer survival by inhibiting Ran. There is an inverse correlation between Ran and NR1D1, playing a crucial role in aneuploid cells. Ran affects DNA repair pathways by destabilizing NR1D1 mRNA through miR4472 interference.
Article
Biochemistry & Molecular Biology
Mingyu Kang, Joon H. H. Kang, In A. Sim, Do Y. Seong, Suji Han, Hyonchol Jang, Ho Lee, Sang W. Kang, Soo-Youl Kim
Summary: Previous work has shown that cancer cells rely on fatty acid oxidation rather than glycolysis for ATP production. However, this study found that some cancer cells undergo cell death when deprived of glucose, resulting in a decrease in ATP production. The response to glucose deprivation was different between glucose insensitive cancer cells (GIC) and glucose sensitive cancer cells (GSC). Glucose deprivation induced cell death in GSC, but not GIC, indicating that GIC have a higher tolerance for decreased NADPH levels. The findings suggest that glucose deprivation-induced cancer cell death is independent of ATP depletion, but rather caused by a failure of ROS regulation by the antioxidant system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Stephanie L. E. Compton, Joseph P. Grieco, Benita Gollamudi, Eric Bae, Jennifer H. Van Mullekom, Eva M. Schmelz
Summary: During the metastasis of ovarian cancer, spheroids undergo changes in metabolism and fuel utilization as they adhere to secondary sites. The adhesion triggers a metabolic switch, where spheroids primarily use glutamine and glucose as fuel sources to support growth and successful metastasis. Understanding this process can help identify drug targets that can inhibit these metabolic signaling pathways and prevent ovarian cancer metastases from growing and invading other tissues.
Review
Cell Biology
Carmen Rodriguez, Noelia Puente-Moncada, Russel J. Reiter, Ana M. Sanchez-Sanchez, Federico Herrera, Jezabel Rodriguez-Blanco, Cristina Duarte-Olivenza, Maria Turos-Cabal, Isaac Antolin, Vanesa Martin
Summary: Multiple oncogenic pathways and local microenvironmental conditions converge on regulating cancer cell metabolism, with melatonin considered a therapeutic target due to its reported antitumor effects. High concentrations of melatonin have shown effectiveness in reducing cell growth and inducing cell death in certain types of tumors, suggesting its potential role in regulating glucose metabolism in cancer cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Pingping Su, Lirui Yu, Xiaodan Mao, Pengming Sun
Summary: Oxygen is crucial for energy metabolism in tumors, which often occur in a hypoxic microenvironment. The interaction between HIF-1 alpha and ERR alpha plays a key role in regulating the metabolic and functional changes in cancer cells. This review gives an overview of the tumor metabolic reprogramming involving HIF-1 alpha/ERR alpha and explores their role in promoting tumor growth adaptation and pyroptosis resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng
Summary: This study reveals that ENO2 is highly expressed in head and neck squamous cell carcinoma (HNSCC) and promotes cell proliferation and glycolysis by controlling PKM2 protein stability and nuclear translocation. Treatment with the ENO inhibitor AP-III-a4 significantly induces HNSCC remission in a preclinical mouse model.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
