Review
Pharmacology & Pharmacy
Usman Sabir, Hafiz Muhammad Irfan, Alamgeer, Ihtisham Umer, Zahid Rasul Niazi, Hafiz Muhammad Mazhar Asjad
Summary: Literature evidence suggests that natural compounds have the potential to improve obesity-associated non-alcoholic fatty liver disease (NAFLD) by targeting the forkhead box O1 (FOXO1) transcription factor. Certain phytochemicals, such as polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins, can modulate FOXO1 and its associated signaling pathways, making them potential therapeutic agents for NAFLD and related complications.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Geriatrics & Gerontology
Sichao Guo, Ruchi Mangal, Chaitu Dandu, Xiaokun Geng, Yuchuan Ding
Summary: Stroke is a prevalent cause of death worldwide, leading to severe cellular dysfunction and long-term disability. FoxO1 plays a role in regulating cellular processes like gluconeogenesis and glycogenolysis. During stroke, FoxO1 modifications are linked to various functions such as inducing cell death and inflammation, affecting BBB, and regulating hepatic gluconeogenesis.
Article
Oncology
Kaixiang Xu, Wanyun Zhu, Anyong Xu, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei, Hong-Ye Zhao
Summary: This study elucidated the mechanism of paclitaxel (PTX) inducing autophagy in triple-negative breast cancer (TNBC) cells, providing a potential clinical chemotherapy strategy. It was found that PTX induced both apoptosis and autophagy in MDA-MB-231 cells, and inhibition of autophagy promoted apoptotic cell death. FOXO1 was identified as a transcription factor that enhanced PTX-induced autophagy by activating several downstream target genes. Knocking down FOXO1 attenuated the survival of MDA-MB-231 cells in response to PTX treatment. These findings may improve the treatment efficacy of PTX and contribute to the development of autophagic targeted therapy for TNBC.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chao Chen, Yu'e Liu, Hongxiang Wang, Xu Zhang, Yufeng Shi, Juxiang Chen
Summary: We investigated the role of FOXO1 and miR-506 in the progression and drug resistance of GBM. Through in vitro and in vivo experiments, we found that the FOXO1-miR-506 axis suppresses GBM cell invasion and migration and promotes chemosensitivity to TMZ, mediated by autophagy. We also discovered a negative feedback loop of FOXO1/miR-506/ETS1/FOXO1 in regulating invasiveness and chemosensitivity in GBM.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Cell Biology
Yixuan Jiang, Wenqiong Luo, Feng Zhou, Ping Gong, Yi Xiong
Summary: This study found that FOXO1 plays an important regulatory role in bone formation, and autophagy may be one of its underlying mechanisms.
Review
Pharmacology & Pharmacy
Yan Wang, Weichun He
Summary: A significant proportion of diabetes patients will develop kidney disease, with Diabetic Kidney Disease (DKD) being a major complication and leading cause of end-stage kidney disease worldwide. FoxO1 transcription factor plays a crucial role in the pathogenesis of DKD and may be a potential clinical target for prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-liang Sun, Ling-yan He, Li Liang, Si-yu Liu, Jie Luo, Mei-ling Lv, Zheng-wen Cai
Summary: This study identifies a novel pathway, Ambra1-Akt-FoxO1-Bim, which regulates apoptosis and chemosensitivity in breast cancer cells by modulating the expression of the key protein Bim.
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Yow Keat Tham, Suzan G. Yildiz, Yonali Alexander, Daniel G. Donner, Helen Kiriazis, Claudia A. Harmawan, Amy Hsu, Bianca C. Bernardo, Aya Matsumoto, Ronald A. DePinho, E. Dale Abel, Elizabeth A. Woodcock, Julie R. McMullen
Summary: This study found that the transcription factor FoxO1 is a critical mediator of exercise-induced cardiac hypertrophy, which has important implications when considering FoxO1 as a target for treating the diseased heart. Given that exercise-induced hypertrophy is protective, this finding is significant in the context of treating heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Environmental Sciences
Tae Hong Kang, Kyung Soo Kang, Sang In Lee
Summary: Research has found that DON can induce apoptosis in intestinal epithelial cells through the FOXO3a-signaling pathway, leading to the translocation of FOXO3a into the nucleus. Inhibiting FOXO3a can alleviate apoptosis and the expression of apoptosis-related genes. Additionally, treatment with an ERK1/2 inhibitor can suppress the translocation of FOXO3a into the nucleus.
Article
Cardiac & Cardiovascular Systems
Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos
Summary: The study revealed that diabetic cardiomyopathy (DbCM) is associated with increased cardiac expression of KLF5, which is regulated by FOXO1. KLF5 induces DbCM by promoting oxidative stress through NOX4 and ceramide accumulation in the heart. Inhibiting KLF5 could alleviate superoxide formation and improve cardiac function in diabetic mice.
CIRCULATION RESEARCH
(2021)
Review
Oncology
Shaojie Yang, Liwei Pang, Wanlin Dai, Shuodong Wu, Tengqi Ren, Yunlong Duan, Yuting Zheng, Shiyuan Bi, Xiaolin Zhang, Jing Kong
Summary: Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, with surgical resection being the main treatment. Foxo proteins play crucial roles in HCC and are considered multifunctional targets for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Liangfeng Jiang, Pinger Li, Shengjun Chen
Summary: AT-I enhances cisplatin sensitivity in renal cell carcinoma cells through activation of the FOXO1-ATG5 pathway-mediated excessive autophagy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Xiaoling Zhang, Tao Li, Shiying Shao
Summary: This study found that exenatide can restore the Th17/Treg balance in obese diabetic mice by regulating the FoxO1 pathway, thereby improving the progression of diabetes and protecting pancreatic beta-cell function.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yanan Hu, Lu Yi, Yeyi Yang, Zhixiang Wu, Min Kong, Zhijuan Kang, Zuocheng Yang
Summary: Viral myocarditis is a major cause of sudden cardiac death in children and young adults, with coxsackievirus B3 being the most common causative agent. Signaling pathways play a key role in the pathogenesis of viral myocarditis, offering potential therapeutic targets. This study reveals that CVB3 infection induces apoptosis through the FOXO1 acetylation-Bim pathway, suggesting new insights for potential therapeutic targets in enteroviral myocarditis.
