Article
Pharmacology & Pharmacy
Upendra Chitgupi, Yiru Qin, Sanjana Ghosh, Breandan Quinn, Kevin Carter, Xuedan He, Ulas Sunar, Jonathan F. Lovell
Summary: This study developed folic acid-decorated light-sensitive liposomes for targeted delivery of chemotherapeutic drugs and demonstrated the efficacy of chemophototherapy in treating tumors. In vitro and in vivo experiments showed that the light treatment could delay tumor growth and improve survival rates. Additionally, the results suggested that the folic acid decoration was not essential for the anti-tumor response.
Article
Chemistry, Multidisciplinary
Andrew S. Choi, Taylor J. Moon, Walid Abuhashim, Anubhuti Bhalotia, Huikang Qian, Kai E. Paulsen, Morgan Lorkowski, Crystal Ndamira, Ramamurthy Gopalakrishnan, Animesha Krishnamurthy, William P. Schiemann, Efstathios Karathanasis
Summary: Targeted nanoparticles are unable to distinguish cancer metastasis from general inflammation, which has clinical implications for nanoparticle-mediated delivery of cancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Jiawen Zhao, Liang Zhang, Yingjie Qi, Kui Liao, Zhigang Wang, Ming Wen, Di Zhou
Summary: The study successfully developed multifunctional nanoparticles with targeted therapeutic and diagnostic imaging capabilities for combination therapy of ovarian cancer. These nanoparticles showed excellent dispersity, stability, and optical properties, with a combination of photothermal conversion and chemotherapy achieving highly efficient therapy both in vitro and in vivo. The nanoparticles have the potential for therapeutic guidance and monitoring, with outstanding imaging capabilities for both photoacoustic and X-ray computed tomography imaging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Maria Anzengruber, Lisa Marie Nepustil, Fatlinda Kurtaj, Ammar Tahir, Katharina Skoll, Haider Sami, Michael Wirth, Franz Gabor
Summary: In this study, a one-step method was proposed for the preparation of nanoparticles with tailored functionalities. The results showed that the strategy could effectively control the targeting and stealth effects of the nanoparticles, and the initial ratio of the building blocks could easily fine-tune the ligand density and cell association.
Article
Medicine, Research & Experimental
M. A. Sanzhakov, V. A. Kudinov, K. K. Baskaev, G. E. Morozevich, D. S. Stepanova, T. I. Torkhovskaya, Yu. A. Tereshkina, E. I. Korotkevich, E. G. Tikhonova
Summary: The study focused on constructing composite phospholipid-gold nanoparticles using soy phosphatidylcholine and a targeted ligand to enhance specific delivery into tumor cells and visualization of malignant neoplasms. In vitro and in vivo experiments demonstrated a significant increase in accumulation of the nanoparticles with a targeted fragment, showing promising potential for early diagnosis and treatment of various types of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Londiwe Simphiwe Mbatha, Fiona Maiyo, Aliscia Daniels, Moganavelli Singh
Summary: Messenger RNA (mRNA) has been overlooked for gene therapy due to its instability, but recent studies have shown its advantages over DNA in cancer immunotherapy and vaccine development. This study successfully formulated folic-acid-(FA)-modified, poly-amidoamine-generation-5 (PAMAM G5D)-grafted gold nanoparticles (AuNPs) and demonstrated higher transgene expression in FA receptor-overexpressing cells, highlighting the importance of AuNP delivery system.
Article
Biochemistry & Molecular Biology
Elena Bellotti, Maria Grazia Cascone, Niccoletta Barbani, Daniela Rossin, Raffaella Rastaldo, Claudia Giachino, Caterina Cristallini
Summary: Chemotherapeutics are commonly used for cancer treatment, but often have off-target effects on healthy cells. Gene therapy is becoming a trend in oncotherapy, aiming to safely deliver genetic material to target cells using non-viral carriers. Using terpolymer-based nanocapsules decorated with folic acid for active targeting shows potential for more effective cancer therapies.
Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Varsha Shetty, Alok Jakhade, Kavita Shinde, Rajeev Chikate, Ruchika Kaul-Ghanekar
Summary: Cinnamaldehyde loaded magnetic nanoparticles functionalized with FITC and folic acid showed promising potential for imaging and active drug targeting in breast cancer, with increased uptake in cancer cells and reduced tumor burden in mouse models. Further safety studies are warranted before potential clinical applications.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiaosheng Bai, Yan Lin, Lingyi Gong, Junfeng Duan, Xiaoduan Sun, Changguang Wang, Zerong Liu, Jun Jiang, Xiangyu Zhou, Meiling Zhou, Zhirong Zhang, Zhongbing Liu, Pei Jing, Zhirong Zhong
Summary: Researchers have developed a novel nanoparticle system that inactivates the mitochondria of tumor cells to provide adequate local oxygen concentrations for photodynamic therapy. The nanoparticles solubilize the photosensitizer, prolong its circulation, and enhance its antitumor effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Pedram Ebrahimnejad, Arezoo Sodagar Taleghani, Kofi Asare-Addo, Ali Nokhodchi
Summary: Targeted nanocarriers, modified with folate ligands, can deliver drugs to cancer cells at the right time and reduce drug doses to minimize side effects. This review highlights the latest developments and discusses the toxicity, biocompatibility, and efficacy of folate-conjugated nanoparticles in cancer diagnosis and treatment.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Vellingiri Yasothamani, Laxmanan Karthikeyan, Selvaraj Shyamsivappan, Yuvaraj Haldorai, Dayakar Seetha, Raju Vivek
Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.
Article
Materials Science, Biomaterials
Vellingiri Yasothamani, Raju Vivek
Summary: This study presents a strategy of combining immune checkpoint blockade with nanoparticles for targeted breast cancer treatment. The nanoparticles can activate an immune response and develop immune resistance based on PD-L1 checkpoint, resulting in tumor eradication and inhibition of tumor recurrence.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Borhaneh Hasan-Nasab, Pedram Ebrahimnejad, Pouneh Ebrahimi, Faezeh Sharifi, Maryam Salili, Fatemeh Shahlaee, Ali Nokhodchi
Summary: Nanoparticles loaded with irinotecan and targeted to folate receptors in colorectal tumors were efficiently synthesized, exhibiting prolonged release and high anti-tumor activity. The chemical structure of polymers, optimization of formulation using Box-Behnken design, and characterization of nanoparticles were crucial steps in proving the suitability of targeted delivery of irinotecan in folate positive cancers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Su-Hyun Kwon, Hasan Al Faruque, Hyeonwoo Kee, Eunjoo Kim, Sukho Park
Summary: The study introduces an exosome-based hybrid nanostructure with improved targeting ability and therapeutic efficacy against colorectal cancer. By utilizing exosomes as a carrier and adding a tumor-targeting ligand, the structure exhibits enhanced targeting performance. Through in vitro and in vivo experiments, it was found that the structure could induce increased apoptosis and effectively inhibit tumor growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Medical Laboratory Technology
Angel San Miguel-Rodriguez, Alicia Armentia, Sara Martin-Armentia, Blanca Martin-Armentia, Alfredo Corell, Ma Carmen Lozano-Estevan, Irene Iglesias Peinado
CLINICA CHIMICA ACTA
(2019)
Article
Health Care Sciences & Services
Maria Belen Marzal-Alfaro, Vicente Escudero-Vilaplana, Carmen Guadalupe Rodriguez-Gonzalez, Eva Gonzalez-Haba, Aitana Calvo, Santiago Osorio, Irene Iglesias-Peinado, Ana Herranz, Maria Sanfurjo
Summary: This study aimed to analyze the prevalence of errors and associated costs with the implementation of an image-based workflow management system during the antineoplastic compounding process. Results showed that Phocus Rx system effectively prevented errors reaching patients and was cost-effective from the hospital's perspective.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Pharmacology & Pharmacy
Maria Angeles Campos Fernandez de Sevilla, Marta Gallego Ubeda, Miriam Heredia Benito, Emilio Garcia-Cabrera, Beatriz Monje Garcia, Maria Tovar Pozo, Laura Delgado Tellez de Cepeda, Irene Iglesias-Peinado
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2019)
Article
Medical Informatics
Sara Ibanez-Garcia, Carmen Rodriguez-Gonzalez, Vicente Escudero-Vilaplana, Maria Luisa Martin-Barbero, Belen Marzal-Alfaro, Jose Luis De la Rosa-Trivino, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo Saez
APPLIED CLINICAL INFORMATICS
(2019)
Article
Pharmacology & Pharmacy
Maria Angeles Campos Fernandez de Sevilla, Marta Gallego Ubeda, Maria Tovar Pozo, Emilio Garcia-Cabrera, Beatriz Monje Garcia, Federico Tutau Gomez, Laura Delgado Tellez de Cepeda, Irene Iglesias-Peinado
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2019)
Article
Health Care Sciences & Services
Mbelen Marzal-Alfaro, Carmen Guadalupe Rodriguez-Gonzalez, Vicente Escudero-Vilaplana, Jose Luis Revuelta-Herrero, Eva Gonzalez-Haba, Sara Ibanez-Garcia, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo Saez
HEALTH INFORMATICS JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Rosa Romero Jimenez, Irene Iglesias Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2020)
Article
Pharmacology & Pharmacy
Estrella Diaz Gomez, David Suarez Del Olmo, Laura Corregidor Luna, Irene Iglesias-Peinado, Benito Garcia Diaz
Summary: This study evaluates the risk of bleeding in patients with renal insufficiency during treatment or prophylaxis with dalteparin and finds that patients with renal insufficiency are at a higher risk of bleeding than those with normal renal function.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Health Care Sciences & Services
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Cristina Gonzalez-Anleo, Maite Martin-Conde, Rosa Romero-Jimenez, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
JMIR MHEALTH AND UHEALTH
(2020)
Article
Pharmacology & Pharmacy
Lorena de Agustin Sierra, Jaime Rodriguez Salazar, Ana Belen Jimenez-Munoz, Maria Jesus Molina Hernandez, Paloma Bermejo Bescos, Irene Iglesias Peinado, Benito Garcia Diaz
Summary: Compared the prevalence of potentially inappropriate medication in the elderly using PRISCUS list, STOPP criteria, and Beers criteria. Found that explicit criteria are useful for identifying inappropriate medication use in elderly patients, with further research needed for adaptation and improvement of prescription practices.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Silvia Pena-Cabia, Ana Royuela Vicente, Ruth Ramos Diaz, Fernando Gutierrez Nicolas, Angela Penalver Vera, Isabel Siso Garcia, Ricardo Hitt Sabag, Concepcion Garcia Lacalle, Ana Pena-Cabia, Irene Iglesias-Peinado, Benito Garcia Diaz, Ana Lopez-Martin
Summary: Limited literature is available on the exposure-response relationship of bevacizumab, and no concentration threshold is associated with optimal disease control. This real-life observational study aimed to evaluate the relationship between bevacizumab concentrations at steady state and disease control in patients with metastatic colorectal cancer. While no positive association was found with clinical benefit, a higher median Ctrough, SS was associated with better overall survival. More controlled randomized studies are needed to confirm these findings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Ana Maria Martinez-Relimpio, Marta Benito, Elena Perez-Izquierdo, Cesar Teijon, Rosa Maria Olmo, Maria Dolores Blanco
Summary: Utilizing folate-targeted crosslinked nanoparticles based on BSA and alginate mixtures loaded with paclitaxel (PTX) has shown promising results in cancer treatment by enhancing the drug's antineoplastic activity against solid tumors. The sustained release of PTX from the nanoparticles led to a gradual decrease in cell viability, demonstrating the efficacy of the targeted nanocarriers in delivering the drug to cancer cells with overexpressed folate receptors.
Article
Immunology
Gonzalo Ruiz-Perez, Samuel Ruiz de Martin Esteban, Sharai Marques, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martinez-Relimpio, M. Andrea Arnanz, Rosa M. Tolon, Maria Posada-Ayala, Benjamin F. Cravatt, Jose A. Esteban, Julian Romero, Rocio Palenzuela
Summary: The study investigates the cellular and molecular mechanisms associated with improving neurodegeneration in 5xFAD mouse model by modulating the endocannabinoid system. The results demonstrate that increasing endocannabinoid tone rescues hippocampal synaptic plasticity and triggers augmented microglial activation and amyloid beta phagocytosis, leading to reversal of the neuronal phenotype associated with Alzheimer's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Samuel Ruiz de Martin Esteban, Irene Benito-Cuesta, Itziar Terradillos, Ana M. Martinez-Relimpio, M. Andrea Arnanz, Gonzalo Ruiz-Perez, Claudia Korn, Catarina Raposo, Roman C. Sarott, Matthias V. Westphal, Izaskun Elezgarai, Erick M. Carreira, Cecilia J. Hillard, Uwe Grether, Pedro Grandes, M. Teresa Grande, Julian Romero
Summary: The cannabinoid CB2 receptors are found to be significantly elevated in chronic neuroinflammatory states associated with neurodegenerative diseases such as Alzheimer's disease, suggesting a potential therapeutic target in modulating amyloid metabolism through microglial CB2 receptors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Elsa Izquierdo-Garcia, Ismael Escobar-Rodriguez, Jose Manuel Moreno-Villares, Irene Iglesias-Peinado
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2020)