Article
Polymer Science
Kevin Tobin, Jennifer Fiegel, Nicole K. Brogden
Summary: Transdermal delivery of naltrexone (NTX) can be enhanced by using thermosensitive polymer Poloxamer 407 (P407) gel, which may provide more sustained drug release. Microneedle treatment can enhance NTX permeation, and P407 gels show better permeability and more sustained release compared to aqueous solutions.
Article
Dermatology
Abayomi Tolulope Ogunjimi, Christine Lawson, Jamie Carr, Krishna Kumar Patel, Nkanyezi Ferguson, Nicole K. Brogden
Summary: This study investigated if differences exist in micropore closure timeframes at different anatomical sites (upper arm, volar forearm, and abdomen), and the results showed that anatomical site of application may not significantly affect micropore closure time.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Song Li, Youngeun Kim, Jeong Woo Lee, Mark R. Prausnitz
Summary: Single-use microneedle patches have been developed for painless and bloodless tattooing, which can provide medical information, respond to physiological changes, and encode personal health information. These patches offer increased safety and access to medical tattoos for improved cosmetic outcomes.
Article
Chemistry, Multidisciplinary
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: Microneedles have emerged as a promising platform for transdermal drug delivery. Recent research has shown the potential of using microneedles in combination with cell therapy to address localized conditions and improve treatment efficacy. This study provides an overview of the recent advances, applications, challenges, and future prospects of microneedle-assisted cell delivery.
Review
Pharmacology & Pharmacy
Lalitkumar K. Vora, Akmal H. Sabri, Yara Naser, Achmad Himawan, Aaron R. J. Hutton, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Mingshan Li, Aoife M. Rodgers, Alejandro J. Paredes, Eneko Larran, Raghu Raj Singh Thakur, Ryan F. Donnelly
Summary: The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active compound over a desired period. This review discusses various MN formulations loaded with different therapeutics, the design aspects such as polymer selection and MN geometry, as well as manufacturing and regulatory hurdles that need to be overcome to bring MN technology to the market.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Article
Pharmacology & Pharmacy
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han, Jing Han
Summary: Microneedle patch (MNP) is an alternative drug delivery method with unique advantages, and hyaluronic acid microneedle patch (HA MNP) is a prominent strategy with various applications. In this review, the benefits and applications of HA MNP are summarized, highlighting its potential in drug delivery and disease treatment.
Article
Energy & Fuels
Priya Sahu, Ranjit Mishra, Sonali Panigrahy, Prajnashree Panda, Sudip Barman
Summary: This study developed porous nitrogen-doped carbon materials through a specific method and evaluated their performance in electrochemical energy storage and CO2 adsorption. The results showed that the porous carbon materials exhibited excellent capacitance and CO2 capture capacity, likely due to nitrogen functional groups, high surface area, and micropore-rich structures.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Review
Environmental Sciences
Jonathan W. C. Wong, Uchenna O. Ogbonnaya
Summary: Biochar has the potential to retain nutrients, enhance soil properties, and promote beneficial microbial growth in agricultural soils. However, further research is needed to understand the interactions between biochar and soil microbes, as well as its effects in practical applications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Biomedical
Lindsay Barnum, Jacob Quint, Hossein Derakhshandeh, Mohamadmahdi Samandari, Fariba Aghabaglou, Ali Farzin, Laleh Abbasi, Sidi Bencherif, Adnan Memic, Pooria Mostafalu, Ali Tamayol
Summary: A new drug delivery method combining microneedle arrays and hydrogels has been developed, which can penetrate the skin and control the release of drugs to different tissue depths.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Huiting Lu, Shah Zada, Lingzhi Yang, Haifeng Dong
Summary: The collection and analysis of biological samples play an important role in disease diagnosis and treatment. Traditional blood sampling methods are invasive and require professional intervention, while microneedle-based devices have gained attention due to their noninvasive nature. This review introduces the materials used for microneedle fabrication and discusses their applications in different categories.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Xuexiang Zhang, Mohammad Mahdi Hasani-Sadrabadi, Jana Zarubova, Erfan Dashtimighadam, Reihaneh Haghniaz, Ali Khademhosseini, Manish J. Butte, Alireza Moshaverinia, Tara Aghaloo, Song Li
Summary: Periodontal diseases are caused by microbial infection and destructive immune cells. Researchers have developed a microneedle patch that delivers antibiotics and cytokines to the gingival tissue for immunomodulation and tissue regeneration.
Article
Multidisciplinary Sciences
Ester Caffarel-Salvador, Soyoung Kim, Vance Soares, Ryan Yu Tian, Sarah R. Stern, Daniel Minahan, Raissa Yona, Xiaoya Lu, Fauziah R. Zakaria, Joy Collins, Jacob Wainer, Jessica Wong, Rebecca McManus, Siddartha Tamang, Shane McDonnell, Keiko Ishida, Alison Hayward, Xiewen Liu, Frantisek Hubalek, Johannes Fels, Andreas Vegge, Morten Revsgaard Frederiksen, Ulrik Rahbek, Tadayuki Yoshitake, James Fujimoto, Niclas Roxhed, Robert Langer, Giovanni Traverso
Summary: A highly drug-loaded microneedle patch was developed for rapid delivery of human insulin and growth hormone to the buccal cavity of swine, with the hard palate identified as the preferred application site. This study suggests that microneedle patches could increase medication adherence and provide painless delivery for pediatric and elderly populations.
Review
Pharmacology & Pharmacy
Hiep X. Nguyen, Chien N. Nguyen
Summary: Transdermal delivery has limitations due to the barrier function of the stratum corneum layer, but microneedle technology provides a promising platform for delivering macromolecules by creating microchannels in the skin. This review article summarizes the recent research on microneedle-mediated delivery of macromolecules, covering various topics such as skin introduction, transdermal delivery, microneedles, biopharmaceuticals, safety, manufacturing, and the future of microneedle technology.
Article
Medicine, Research & Experimental
Abhay U. Andar, Ram Karan, Wolf T. Pecher, Priya DasSarma, William D. Hedrich, Audra L. Stinchcomb, Shiladitya DasSarma
MOLECULAR PHARMACEUTICS
(2017)
Article
Chemistry, Multidisciplinary
Soo Hyeon Shin, Priyanka Ghosh, Bryan Newman, Dana C. Hammell, Sam G. Raney, Hazem E. Hassan, Audra L. Stinchcomb
PHARMACEUTICAL RESEARCH
(2017)
Article
Biochemical Research Methods
Mingming Yu, Inas A. Abdallah, Soo Hyeon Shin, Dana C. Hammell, Audra L. Stinchcomb, Hazem E. Hassan
Article
Chemistry, Multidisciplinary
Soo Hyeon Shin, Sherin Thomas, Sam G. Raney, Priyanka Ghosh, Dana C. Hammell, Samer S. El-Kamary, Wilbur H. Chen, M. Melissa Billington, Hazem E. Hassan, Audra L. Stinchcomb
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Neurosciences
Gustavo Gonzalez-Cuevas, Remi Martin-Fardon, Tony M. Kerr, David G. Stouffer, Loren H. Parsons, Dana C. Hammell, Stan L. Banks, Audra L. Stinchcomb, Friedbert Weiss
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Soo Hyeon Shin, Jukkarin Srivilai, Sarah A. Ibrahim, Caroline Strasinger, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb
Article
Biochemical Research Methods
Sheniqua Brown, Paige N. Zambrana, Xudong Ge, Dayanand Bagdure, Audra L. Stinchcomb, Govind Rao, Leah Tolosa
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Sherin Thomas, Soo Hyeon Shin, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Soo Hyeon Shin, Elena Rantou, Sam G. Raney, Priyanka Ghosh, Hazem Hassan, Audra Stinchcomb
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Paige N. Zambrana, Peng Hou, Dana C. Hammell, Tonglei Li, Audra L. Stinchcomb
Summary: This study investigated the mechanism of dermal absorption kinetics from different topical products through experiments and simulation models. The results showed that drug transport kinetics are influenced by various factors, including drug formulation and environmental temperature. Additionally, the drug diffusion coefficient and water content play important roles in drug transport kinetics.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Sagar Shukla, Annette L. Bunge, Hazem E. Hassan, Audra L. Stinchcomb
Summary: The study evaluated the impact of different investigators in studies using a tape stripping protocol to minimize investigator variability. The results showed that the measurements of different investigators are reproducible within the limitations of measurement variability, which can be managed by increasing volunteer numbers.
PHARMACEUTICAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Paige N. Zambrana, Dana C. Hammell, Audra L. Stinchcomb
Summary: Due to high variability during clinical pharmacokinetic (PK) evaluation, it has historically been challenging to predict in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products. This study aimed to establish accurate in vitro/in vivo correlations (IVIVC) by harmonizing experimental parameters and performed in vivo human serum PK evaluation using excised human skin. The results showed excellent IVIVC for four different sunscreen formulations with controlled application time, occlusion, temperature, and humidity, indicating reduced inter-subject variability and reliable testing of complex topical formulations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Sherin Thomas, Dana. C. C. Hammell, Hazem. E. E. Hassan, Audra. L. L. Stinchcomb
Summary: The purpose of this study was to evaluate the correlation between in vitro and in vivo data by conducting permeation studies at normal and elevated temperature conditions. The results showed that external heat using a heating pad can increase systemic levels of buprenorphine, and the in vitro permeation studies were able to predict this enhancement reasonably well.
PHARMACEUTICAL RESEARCH
(2023)
Article
Neurosciences
Daniel J. Liput, James R. Pauly, Audra L. Stinchcomb, Kimberly Nixon
Article
Biochemical Research Methods
Cristina Tiangco, Abhay Andar, Juliana Quarterman, Xudong Ge, Fortunato Sevilla, Govind Rao, Audra Stinchcomb, Annette Bunge, Leah Tolosa
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2017)