RNA Interference and Cancer Therapy

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

PDX-1

(2010) Shi-He Liu et al.   CANCER

Promising human brain tumors therapy with interference RNA intervention (iRNAi)

(2010) Katarzyna Rolle et al.   CANCER BIOLOGY & THERAPY

Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference

(2010) D D Rao et al.   CANCER GENE THERAPY

Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models

(2010) A. Santel et al.   CLINICAL CANCER RESEARCH

A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo

(2010) Q Shi et al.   GENE THERAPY

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

(2010) Xi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

(2010) Li Ma et al.   NATURE BIOTECHNOLOGY

Effect of biological matrix and sample preparation on qPCR quantitation of siRNA drugs in animal tissues

(2010) Jessica Seitzer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Uncovering Growth-Suppressive MicroRNAs in Lung Cancer

(2009) X. Liu et al.   CLINICAL CANCER RESEARCH

Gastrosplenic Fistula From Hodgkin's Lymphoma

(2009) Carolyn D. Seib et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

(2009) Marc T Abrams et al.   MOLECULAR THERAPY

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer

(2009) Junfang Ji et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells

(2009) Takeshi Haraguchi et al.   NUCLEIC ACIDS RESEARCH

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer

(2009) Shihe Liu et al.   PANCREAS

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues

(2009) Guy A Tremblay et al.   Bioanalysis

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

(2008) A. Singh et al.   CANCER RESEARCH

Stathmin 1: a novel therapeutic target for anticancer activity

(2008) Shushan Rana et al.   Expert Review of Anticancer Therapy

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

(2008) Marko Pesu et al.   NATURE

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

(2008) Yvonne Tay et al.   NATURE

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell–mediated suppression

(2008) Xiao-Tong Song et al.   NATURE MEDICINE

An Analysis of Human MicroRNA and Disease Associations

(2008) Ming Lu et al.   PLoS One

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA