Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention

Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells

(2015) Hong-Chao Pan et al.   NEUROCHEMISTRY INTERNATIONAL

Quercetin Regresses Dalton's Lymphoma Growth via Suppression of PI3K/AKT Signaling Leading to Upregulation of p53 and Decrease in Energy Metabolism

(2015) Akhilendra Kumar Maurya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Ellagic Acid Induces Novel and Atypical PKC Isoforms and Promotes Caspase-3 Dependent Apoptosis by Blocking Energy Metabolism

(2014) Sudha Mishra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

(2013) Anatoly Samoylenko et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia

(2013) Fuling Zhou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century

(2013) Soodabeh Saeidnia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Protein Kinase Cδ in Apoptosis: A Brief Overview

(2012) Meng Zhao et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The role of TRADD in death receptor signaling

(2012) Yelena L. Pobezinskaya et al.   CELL CYCLE

Protein kinase Cα protects against multidrug resistance in human colon cancer cells

(2012) Se-Kyoung Lee et al.   MOLECULES AND CELLS

Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2

(2011) Chi-Tan Hu et al.   CLINICAL & EXPERIMENTAL METASTASIS

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing mice

(2011) Sudha Mishra et al.   LEUKEMIA & LYMPHOMA

Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

(2010) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting of Tumor Necrosis Factor Receptor 1 to Low Density Plasma Membrane Domains in Human Endothelial Cells

(2010) Alessio D'Alessio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Hallmarks for senescence in carcinogenesis: novel signaling players

(2009) M. Cecilia Caino et al.   APOPTOSIS

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells

(2009) Chi-Hao Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Protein kinase Cα: disease regulator and therapeutic target

(2009) Olga Konopatskaya et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C  Limits Fc  Receptor-Mediated Phagocytosis in Macrophages

(2008) K. Hazeki et al.   JOURNAL OF BIOCHEMISTRY

Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells

(2008) Ana Belén Granado-Serrano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease

(2008) Anumantha G Kanthasamy et al.   Molecular Brain

TNFα acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-κB-dependent pathways

(2007) Martín A. Rivas et al.   EXPERIMENTAL CELL RESEARCH

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS