期刊
PHARMACEUTICAL RESEARCH
卷 25, 期 7, 页码 1723-1729出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-008-9572-9
关键词
camptothecin; oral drug delivery; PAMAM dendrimer; SN-38
资金
- NIBIB NIH HHS [R01 EB007470-02, R01 EB007470-01A2, R01 EB007470-03, R01EB07470, R01 EB007470] Funding Source: Medline
Purpose. To investigate potential application of poly(amidoamine) (PAMAM) dendrimers for improving the delivery of SN-38. Methods. Complexes of SN-38 with generation 4 amine terminated PAMAM dendrimers were synthesized with varying amounts of drug. Stability of the complexes as well as influence of complexation on permeability across and cellular uptake by Caco-2 cells was evaluated. Results. The complexes were stable at pH 7.4 and drug was released at pH 5. A tenfold increase in permeability and more than hundredfold increase in cellular uptake of the complexes with respect to free SN-38 was observed. Conclusions. Studies suggest that complexation with PAMAM dendrimers has the potential to improve the oral bioavailability of SN-38.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据