Article
Pharmacology & Pharmacy
Zubida M. Al-Majdoub, Daniel Scotcher, Brahim Achour, Jill Barber, Aleksandra Galetin, Amin Rostami-Hodjegan
Summary: Translation modeling of local drug concentrations has seen a significant increase in the past decade. In relation to the kidney, these models serve as a bridge for understanding drug disposition. This study identified multiple enzymes and transporters in human kidney cortex samples, establishing an open database and revealing correlations between enzyme and transporter abundance and activity.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ian E. Templeton, Karen Rowland-Yeo, Hannah M. Jones, Christopher J. Endres, Ariel R. Topletz-Erickson, Hao Sun, Anthony J. Lee
Summary: A physiologically-based pharmacokinetic (PBPK) model was developed to simulate plasma concentrations of tucatinib. The model accurately predicted tucatinib concentrations and drug-drug interactions in different scenarios after refinement and validation with clinical data.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Joanna Lapczuk-Romanska, Maria Drozdzik, Stefan Oswald, Marek Drozdzik
Summary: The kidney is not only involved in metabolite elimination, but also plays a critical role in pharmacotherapy. Membrane carriers and transporters expressed in kidney tubule epithelial cells are important in drug elimination, determining drug nephrotoxicity and drug-drug interactions, as well as serving as direct drug targets. This review discusses these aspects of kidney transport proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marek Drozdzik, Maria Drozdzik, Stefan Oswald
Summary: Chronic kidney disease may affect the expression and function of membrane carriers and transporters, leading to impaired drug elimination and clinical consequences. Understanding the function of these proteins is crucial for characterizing drug pharmacokinetics, drug actions in the kidney, and defining organ pathophysiology.
Article
Chemistry, Medicinal
Zifei Qin, Peile Wang, Shuyi Duan, Xiaoying Wan, Han Xing, Jing Yang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao
Summary: Isobavachalcone, a naturally occurring chalcone in Psoralea corylifolia, possesses various biological properties such as anticancer, antiplatelet, and antifungal effects. However, there is still unclear about its glucuronidation, glucuronides excretion, and drug-drug interaction involving human cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT) enzymes, and efflux transporters (BCRP and MRPs), which require further investigation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Marek Drozdzik, Stefan Oswald, Agnieszka Drozdzik
Summary: Recent studies indicate that kidney pathology can impact membrane transporters not only in the kidney, but also in the gastrointestinal tract and liver. Alterations in drug transporter function in liver and intestines of kidney failure patients may affect drug metabolism and local drug effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Sedzikowska, Leszek Szablewski
Summary: The kidney plays a crucial role in glucose homeostasis by releasing glucose into the blood stream using carrier proteins for transport. Mutations in genes encoding glucose transporters can lead to renal disorders, impacting glucose transport and renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Peripheral Vascular Disease
Xiaohan Lu, Steven D. Crowley
Summary: Dr Lewis Dahl's observations on renal mechanisms of hypertension are still relevant, as recent experiments show that immune system dysfunction contributes to hypertension. Inflammatory cytokines and reactive oxygen species can alter kidney functions and lead to sustained hypertension. Targeting immune-mediated mechanisms while considering the kidney's importance in blood pressure regulation poses a challenge.
Article
Immunology
Cheng Yang, Charith U. B. Wijerathne, Guo-wei Tu, Connie W. H. Woo, Yaw L. Siow, Susara Madduma Hewage, Kathy K. W. Au-Yeung, Tongyu Zhu, O. Karmin
Summary: Acute kidney injury downregulates renal folate transporter expression, leading to reduced folate uptake by tubular cells and contributing to low folate status in AKI patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pien Rawee, Daan Kremer, Ilja M. M. Nolte, Henri G. D. Leuvenink, Daan J. J. Touw, Martin H. H. De Borst, Stephan J. L. Bakker, Mark R. R. Hanudel, Michele F. F. Eisenga
Summary: Heavy metal exposure has been linked to an increased risk of chronic kidney disease (CKD) and its progression. Iron deficiency, another common problem in CKD patients, is hypothesized to play a crucial role in the damaging effects of heavy metal exposure. Iron receptors upregulated by iron deficiency may lead to increased uptake of heavy metals in the intestine, while iron deficiency may also contribute to the retention of heavy metals in the kidney. Iron supplementation might be a strategy to combat these detrimental processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Deepak Ahire, Mitesh Patel, Sujal V. Deshmukh, Bhagwat Prasad
Summary: In this study, a novel conserved-plus-surrogate peptide (CPSP) approach was developed to determine the absolute compositions and total abundance of UGTs in human liver, intestine, and kidney. The CPSP approach addresses the issue of data inconsistency caused by surrogate peptide-specific digestion. The results of this study can be applied to the in vitro-to-in vivo extrapolation of UGT-mediated drug metabolism.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Multidisciplinary Sciences
Morgan C. Panitchpakdi, Kelly Weldon, Alan Jarmusch, Emily Gentry, Arianna Choi, Yadira D. Sepulveda, Shaden C. Aguirre, Kunyang M. Sun, Jeremiah Momper, Pieter Dorrestein, Shirley Tsunoda
Summary: This study demonstrates the kinetics and metabolism of diphenhydramine in healthy volunteers using skin swab samples in combination with mass spectrometry. The results show that diphenhydramine and its metabolites can be detected on the skin surface non-invasively.
Editorial Material
Cell Biology
Matthew Gilliham, Maria Hrmova
Summary: The recent study by Wang et al. revealed the structure of ALMT1, shedding light on its function and presenting new research opportunities in the field of plant tolerance to aluminum.
Article
Clinical Neurology
Lynne M. Bird, Cesar Ochoa-Lubinoff, Wen-Hann Tan, Gali Heimer, Raun D. Melmed, Amit Rakhit, Jeannie Visootsak, Matthew J. During, Christina Holcroft, Rebecca D. Burdine, Alexander Kolevzon, Ronald L. Thibert
Summary: This study evaluated the safety, tolerability, and exploratory efficacy of Gaboxadol in individuals with Angelman syndrome. Gaboxadol was found to be generally well-tolerated and showed some efficacy in improving symptoms, warranting further studies.
Article
Chemistry, Organic
Megan K. Fraser, Aleksandra Gorecka, Edwin A. Yates, Jonathan A. Iggo, Krzysztof Baj, Andrew V. Stachulski
Summary: The two isomeric monoglucuronides of resveratrol are believed to have valuable biological activities similar to resveratrol itself. Through selective deacylation and subsequent glucuronidation, the desired products were obtained. The stability of these glucuronides in aqueous solution was found to vary significantly, especially the 3-glucuronide's propensity for E/Z isomerisation.
ORGANIC CHEMISTRY FRONTIERS
(2023)