Article
Instruments & Instrumentation
Nahed Mohamed Sallam, Rania Abdel Basset Sanad, Mahgoub Mohamed Ahmed, El-Sayed Khafagy, Mamdouh Ghorab, Shadeed Gad
Summary: The study demonstrates that the nano-spanlastic-based wafer offers a promising improvement in trans-buccal carvedilol delivery system, showing considerable improvement in treating hypertension compared to traditional delivery methods.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Marica B. Ericson, Johan Engblom
Summary: Research has shown that porous particles of appropriate size and porosity can accumulate in hair follicles and furrows on the skin, providing a potential area for drug delivery. The combination of follicle orifices and furrows can cover up to 20% of the skin surface, making them valuable for optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Medicinal
Mohammad Adnan, Md. Faheem Haider, Nazish Naseem, Tanweer Haider
Summary: Skin is a formidable barrier to drug delivery, but the development of transethosomes has enabled drugs to penetrate deeper into the skin for targeted delivery. This review covers the preparation methods, comparison with other lipid vesicles, characterization, and application of transethosomes.
Article
Biochemistry & Molecular Biology
Jannik Rousel, Mahdi Saghari, Lisa Pagan, Andreea Nadaban, Tom Gambrah, Bart Theelen, Marieke L. de Kam, Jorine Haakman, Hein E. C. van der Wall, Gary L. Feiss, Tessa Niemeyer-van der Kolk, Jacobus Burggraaf, Joke A. Bouwstra, Robert Rissmann, Martijn B. A. van Doorn
Summary: This study evaluated the effectiveness of omiganan in the treatment of facial seborrheic dermatitis. The results showed that omiganan did not significantly improve clinical symptoms or other biomarkers. In contrast, ketoconazole significantly reduced disease severity and had positive effects on Malassezia abundances, microbial diversity, and skin barrier function. The importance of evaluating omiganan in the treatment of facial seborrheic dermatitis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Mingyue Cui, Christian Wiraja, Sharon Wan Ting Chew, Chenjie Xu
Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
MOLECULAR PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Mohd Danish Ansari, Zoya Saifi, Jayamanti Pandit, Iram Khan, Pavitra Solanki, Yasmin Sultana, Mohd Aqil
Summary: Nanotechnology-based drug delivery systems have revolutionized drug delivery. Spanlastics, an elastic nanovesicle, has the ability to carry a wide range of drug molecules and is suitable for various routes of administration. This review provides an overview of the composition, structure, advantages, and mechanism of drug penetration of spanlastics.
Review
Pharmacology & Pharmacy
Vaibhavi Srivastava, Vivek Singh, Dharmendra Kumar Khatri, Neelesh Kumar Mehra
Summary: Elastic vesicles serve as effective ocular drug delivery vehicles due to their unique squeezability and deformability, allowing them to overcome ocular barriers and achieve reliable delivery to the eye.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Nivedita Pant, Sarika Wairkar
Summary: Bioflavonoids are naturally derived compounds with various pharmacological actions. However, their low solubility and poor skin penetration limit their therapeutic applications for skin ailments. Nanocrystals of bioflavonoids have been developed to overcome these limitations. This review focuses on the preparation methods, in vitro evaluation, and animal studies of topical nanocrystals of bioflavonoids for different skin ailments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang, Katerina Vavrova, Jonathan F. Lovell, Yumiao Zhang
Summary: This study finds that cabazitaxel (CTX) can be dissolved in alpha-tocopherol at high concentrations exceeding 100 mg mL(-1). The addition of 30% dimethyl sulfoxide (DMSO) to the alpha-tocopherol/CTX solution improves its permeation through human skin. Topical application of CTX using a DMSO and alpha-tocopherol solvent shows significant suppression of tumor growth in nude mice bearing skin cancer xenografts.
Article
Pharmacology & Pharmacy
Fotis Iliopoulos, Chun Fung Tang, Ziyue Li, Annisa Rahma, Majella E. Lane
Summary: The evaluation of bioequivalence (BE) for topical dermatological drug products is challenging, and the aim of this study was to evaluate the use of Confocal Raman Spectroscopy (CRS) for BE assessment. Two commercially available formulations were found to deliver similar amounts of drug across the skin in vitro and resulted in comparable skin uptake values in vivo. This is the first study to demonstrate the capability of CRS for the evaluation of BE for topical products.
Article
Chemistry, Physical
Myoung Jin Ho, Hyun Jin Park, Myung Joo Kang
Summary: A neutral oil-incorporated liposomal system (LOS) was developed to enhance the skin absorption of ascorbic acid (Vit C). Sodium deoxycholate as an edge activator and camellia oil as a neutral oil were found to significantly improve the absorption of Vit C. This optimized lipid nanocarrier shows promise in promoting the skin absorption and dermatological functions of Vit C.
Article
Pharmacology & Pharmacy
Bassant Atef, Rania A. H. Ishak, Sabry S. Badawy, Rihab Osman
Summary: In this study, novel fatty acid vesicles loaded with magnolol were prepared using 10-hydroxy decanoic acid (HDA) and oleic acid (OA) for skin cancer treatment. The performance of different formulations was statistically evaluated in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. Both in vitro and in vivo experiments demonstrated that HDA-based vesicles exhibited better drug permeation and skin deposition, and showed superior efficacy in attenuating DMBA-induced skin cancer.
Article
Chemistry, Multidisciplinary
Carlos Asensio-Regalado, Rosa Maria Alonso-Salces, Blanca Gallo, Luis A. Berrueta, Benedetta Era, Francesca Pintus, Carla Caddeo
Summary: Polyphenols extracted from grape pomace and formulated in transfersomes exhibit significant antioxidant activity and no cytotoxic effects, highlighting their potential for promoting human health.
Review
Biochemistry & Molecular Biology
Janaina Artem Ataide, Julia Cedran Coco, Erica Mendes dos Santos, Viviane Beraldo-Araujo, Jessica Ribeiro Alves Silva, Karine Cappuccio de Castro, Andre Moreni Lopes, Nina Filipczak, Satya Siva Kishan Yalamarty, Vladimir P. P. Torchilin, Priscila Gava Mazzola
Summary: The main goal of medicine is to achieve the best possible outcome for therapy. Nanocarriers and co-delivery strategies have been invented to meet this need, benefiting not only cancer treatment but also many other clinical issues, especially skin diseases. This review aims to summarize the research state of nanocarriers and co-delivery strategies for topical agents' applications targeting skin diseases. The challenge for future medicine lies in delivering drugs with spatial and temporal control, and the co-encapsulation of drugs and appropriate administration forms are important and unmet needs.
