期刊
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 17, 期 1, 页码 40-47出版社
INFORMA HEALTHCARE
DOI: 10.3109/10837450.2010.513986
关键词
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The design of a film coating technology which allows a tablet to deliver the drug in the ileocolonic segment would offer new treatment possibilities. The objective is to develop a platform technology that is suitable for a broad range of drug compounds. We developed a coated tablet with a delayed, pulsatile release profile based on a pH-sensitive coating technology (ColoPulse). The production process was validated, and the effect of core composition on the in vitro release and water uptake investigated. The release profile of the standard tablet core composition, based on the use of cellulose as a filler, was independent of the coat thickness in a range of 9.0-13.2 mg/cm
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