期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 46, 期 12, 页码 715-719出版社
SPRINGER
DOI: 10.1007/s11094-013-0876-7
关键词
[3+2]-cycloaddition and condensation reactions; carbamate-functionalized spiro compounds; antimicrobial and antifungal activity
A series of carbamate-functionalized spiro compounds were synthesized by [3+2]-cycloaddition and condensation reactions based on methyl {4(3)-[2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetyl]phenyl}carbamates. The antimicrobial activity with respect to E. coli, S. aureus 209, and Micrococcus and antifungal activity with respect to Microsporum canis, Trichophyton rubrum, and Candida albicans were investigated. The most active of the synthesized compounds were spiro compounds with isoxazoline and pyrazole fragments.
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