Article
Chemistry, Multidisciplinary
Lukas Christian Sebeke, Juan Daniel Castillo Gomez, Edwin Heijman, Pia Rademann, Alexandra Claudia Simon, Sandra Ekdawi, Susan Vlachakis, Dennis Toker, Ben Lasse Mink, Claudia Schubert-Quecke, Sin Yuin Yeo, Patrick Schmidt, Christina Lucas, Susanne Brodesser, Martin Hossann, Lars H. Lindner, Holger Gruell
Summary: In this article, the localized release of doxorubicin (DOX) from thermosensitive liposomes was achieved using MR-HIFU mediated hyperthermia in a swine model. The study showed a significant increase in DOX concentration in the muscle tissue after hyperthermia treatment, and there was a correlation between the pharmacokinetics of DOX in the bloodstream and its accumulation in the target tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Stefan Nitica, Ionel Fizesan, Roxana Dudric, Felicia Loghin, Constantin Mihai Lucaciu, Cristian Iacovita
Summary: This paper presents a simple method for preparing thermosensitive magnetoliposomes loaded with doxorubicin. The liposomes showed no toxicity against cancer cells at low concentrations, but when the drug was released and the cells were exposed to a magnetic field, their viability significantly decreased.
Article
Pharmacology & Pharmacy
Mohamad Alawak, Alice Abu Dayyih, Gihan Mahmoud, Imran Tariq, Lili Duse, Nathalie Goergen, Konrad Engelhardt, Shashank Reddy Pinnapireddy, Jarmila Jedelsk, Muhannad Awak, Alexander M. Konig, Jana Bruessler, Joerg W. Bartsch, Udo Bakowsky
Summary: The overexpression of ADAM8 in TNBC cells can be exploited for targeted therapy, with specific drug delivery resulting in increased intracellular accumulation and enhanced cytotoxic effects at the cellular target site.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Elsaid Nasr Elghobary, Masayuki Munekane, Kenji Mishiro, Takeshi Fuchigami, Kazuma Ogawa
Summary: Thermosensitive liposomes (TSLs) encapsulating I-125-labeled doxorubicin (DOX) were developed for Auger electron therapy, targeting cancer cell DNA. The radioiodinated DOX derivative [I-125]5 accumulated in the nuclei of cancer cells and showed potent cytotoxicity against Colon 26 cancer cells by Auger electrons. TSLs encapsulating [I-125]5 demonstrated efficient release at 42 degrees C and high uptake in the nuclei, suggesting their potential as an effective cancer therapy.
Article
Chemistry, Medicinal
Hamzah Maswadeh, Arif Khan, Mohammed S. Alorainy, Naser A. Al-Wabel, Costas Demetzos
Summary: Thermosensitive liposomes loaded with cisplatin and doxorubicin were prepared and their effects on cellular proliferation and IC50 in breast and prostate cancer cell lines were studied. The results showed that the drugs loaded in thermosensitive liposomes had higher inhibitory effects at high temperatures and were more effective than free drugs. In vivo experiments also demonstrated better tumor growth inhibition with thermosensitive liposomes.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2022)
Article
Oncology
Hamzah M. Maswadeh, Arif Khan, Mohammed S. Alorainy, Naser A. Al-Wabel, Costas Demetzos
Summary: The potential of concomitant delivery of cisplatin and doxorubicin containing thermosensitive liposomes in mild hyperthermia was investigated in this study. The results showed that the thermosensitive liposomes had a diameter of 120 nm and exhibited changes in drug-phospholipid interaction and compatibility. Cis-Dox-TSL demonstrated higher efficacy in inhibiting tumor growth under hyperthermic conditions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Materials Science, Biomaterials
Shanzhou Huang, Zuyi Ma, Chengjun Sun, Qi Zhou, Zhenchong Li, Shujie Wang, Qian Yan, Chunsheng Liu, Baohua Hou, Chuanzhao Zhang
Summary: In this study, a local injectable hydrogel delivery system was used to construct a platform for synergistic chemo-photothermal therapy for multi-drug resistant hepatocellular carcinoma. The prepared hydrogel had injectable properties and stable photothermal conversion, and could release therapeutic agents on demand for up to 14 days. The platform showed promising results in improving the antitumor efficacy for multi-drug resistant cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Xia Cao, Qi Liu, Wenwan Shi, Kai Liu, Tianwen Deng, Xuedi Weng, Siting Pan, Qingtong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Gao Xiao, Ximing Xu
Summary: A microfluidic chip device was used to load BDMC into a lipid bilayer, forming BDMC thermosensitive liposomes. The addition of glycyrrhizin improved the solubility of BDMC. The fabricated liposomes showed strong inhibitory effects on cancer cells, with a dose-dependent inhibitory effect on cell migration. Further enhancement of anti-tumor effects was achieved by combining with mild local hyperthermia.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Spectroscopy
Sulistiawati, Cindy Kristina Enggi, Hansel Tridatmojo Isa, Stevens Wijaya, Komang Agus Rai Ardika, Rangga Meidianto Asri, Ryan F. Donnelly, Andi Dian Permana
Summary: This study provides analytical method support for the development of a new drug delivery system for CAB. The UV-visible spectrophotometry method was validated for the quantification of CAB in gel preparations, in vitro, and ex vivo studies. The results showed uniformity of drug release in the thermosensitive and mucoadhesive vaginal gels, which maintained controlled release for 24 hours.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Pharmacology & Pharmacy
Nicholas Borys, Mark W. Dewhirst
Summary: LTLD is the first heat-activated formulation of a liposomal drug carrier utilized in human clinical trials, designed to release therapeutic drugs at heated tumors. The drug has shown some successes in preclinical and clinical trials, but also encountered challenges in the development process.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Eduard Preis, Alice Abu Dayyih, Mohamed Alawak, Hassan Mohamed El-Said Azzazy, Udo Bakowsky, Tamer Shoeib
Summary: Thermosensitive liposomes have been designed to release chemotherapeutics in a temperature-responsive manner, showing significant anticancer activity in human breast cancer cells.
Article
Pharmacology & Pharmacy
Shirleide Santos Nunes, Juliana de Oliveira Silva, Renata Salgado Fernandes, Sued Eustaquio Mendes Miranda, Elaine Amaral Leite, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Geovanni Dantas Cassali, Danyelle M. Townsend, Monica Cristina Oliveira, Andre Luis Branco de Barros
Summary: PEGylated liposomes are widely studied as drug delivery systems, but their interaction with cells may be hindered by the addition of PEG. This study compared the characteristics and drug delivery capabilities of PEGylated and non-PEGylated liposomes. The results showed that non-PEGylated liposomes had better cellular uptake and were more effective in controlling tumor growth.
Article
Polymer Science
Waad H. Abuwatfa, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Temperature changes can be used to release drugs from thermosensitive nanoparticles. Combining hyperthermia with smart drug delivery systems can effectively inhibit tumor growth. Thermoresponsive drug delivery systems enhance drug bioavailability and improve therapeutic effects by targeting specific anatomical sites.
Article
Pharmacology & Pharmacy
Alice Abu Dayyih, Mohamad Alawak, Abdallah M. Ayoub, Muhammad U. Amin, Wael Abu Dayyih, Konrad Engelhardt, Lili Duse, Eduard Preis, Jana Bruessler, Udo Bakowsky
Summary: Optimized Hyp thermosensitive liposomes (HypTSL) demonstrated good colloidal stability and high encapsulation efficiency, exhibiting thermal sensitivity at 42 degrees Celsius. The uptake of Hyp-TSL by MDA-MB-231 cells and cellular reactive oxygen species production were significantly enhanced at 42 degrees Celsius, leading to improved tumor drug availability and therapeutic outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Hua Zhang, Wei-Lun Tang, Azadeh Kheirolomoom, Brett Z. Fite, Bo Wu, Kenneth Lau, Mo Baikoghli, Marina Nura Raie, Spencer K. Tumbale, Josquin Foiret, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, R. Holland Cheng, Alexander D. Borowsky, Katherine W. Ferrara
Summary: A formulation using R848-loaded thermosensitive liposomes (TSLs) was developed for intravenous delivery, showing efficacy in tumor regression and enhanced survival when combined with alpha PD-1 in mouse models of breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
