期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 43, 期 5, 页码 242-244出版社
SPRINGER
DOI: 10.1007/s11094-009-0287-y
关键词
benzofuran; hydrazide; isothiocyanate; thiosemicarbazide; mercaptotriazole; S-alkylation; benzyl chlorides; alpha-haloacids
A series of 3-benzofuryl-4-phenyl(allyl)-5-mercapto-1,2,4-triazoles have been synthesized by cyclization of the corresponding substituted thiosemicarbazides of benzofuran-2-carboxylic acid. S-alkylation of 5-mercaptotriazoles with various alkyl-, alkenyl-, and benzyl-substituted benzyl chlorides; chloroacetamides; and chloroacetic-, 2-bromopropionic-, and 2-bromocaproic acids has been studied. The antitumor activity of the synthesized compounds was tested.
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