Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

Long-term use of low-dose spironolactone in spontaneously hypertensive rats: Effects on left ventricular hypertrophy and stiffness

(2014) Marcelo P. Baldo et al.   Pharmacological Reports

Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism

(2013) Adam P. McGraw et al.   Journal of the American Heart Association

Effects of Aldosterone on Human Atherosclerosis: Plasma Aldosterone and Progression of Carotid Plaque

(2012) Omar de Rita et al.   CANADIAN JOURNAL OF CARDIOLOGY

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Contribution of Endogenous Glucocorticoids and Their Intravascular Metabolism by 11β-HSDs to Postangioplasty Neointimal Proliferation in Mice

(2012) Javaid Iqbal et al.   ENDOCRINOLOGY

Altered Functioning of Both Renal Dopamine D1 and Angiotensin II Type 1 Receptors Causes Hypertension in Old Rats

(2012) Gaurav Chugh et al.   HYPERTENSION

Eplerenone Reduced Lesion Size in Early but Not Advanced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2012) Ayelet Raz-Pasteur et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

SM-368229, a Novel Promising Mineralocorticoid Receptor Antagonist, Shows Antihypertensive Efficacy With Minimal Effect on Serum Potassium Level in Rats

(2012) Tetsuro Nariai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Vascular Disturbances in Primary Aldosteronism: Clinical Evidence

(2012) J. Widimsky Jr. et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II–induced cardiac, renal, and vascular injury

(2012) James M. Luther et al.   KIDNEY INTERNATIONAL

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Antihypertensive and Cardiorenal Protective Effects of SM-368229, a Novel Mineralocorticoid Receptor Antagonist, in Aldosterone/Salt-Treated Rats

(2012) Tetsuro Nariai et al.   PHARMACOLOGY

Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat

(2012) Wei Luo et al.   PLoS One

Nongenomic actions of aldosterone and progesterone revisited

(2012) Alexandra Wendler et al.   STEROIDS

Initiation of Angiogenesis in Atherosclerosis: Smooth Muscle Cells as Mediators of the Angiogenic Response to Atheroma Formation

(2012) Benoît Ho-Tin-Noé et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Measuring and targeting aldosterone and renin in atherosclerosis—A review of clinical data

(2011) Marieke A. Hillaert et al.   AMERICAN HEART JOURNAL

Reduced Dietary Salt for the Prevention of Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials (Cochrane Review)

(2011) R. S. Taylor et al.   AMERICAN JOURNAL OF HYPERTENSION

Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress–Dependent and –Independent Pathways

(2011) Brenna G. Newfell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

(2011) Xiaoyan Zhou et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure

(2011) Fabrice Ivanes et al.   EUROPEAN HEART JOURNAL

Endogenous aldosterone is involved in vascular calcification in rat

(2011) Sheng-Ying Wu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion

(2011) Katarzyna Stolarz-Skrzypek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mineralocorticoid receptors in vascular function and disease

(2011) Amy McCurley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Progenitor cell-derived smooth muscle cells in vascular disease

(2010) Augusto Orlandi et al.   BIOCHEMICAL PHARMACOLOGY

Expanding view of aldosterone action, with an emphasis on rapid action

(2010) Gavin P. Vinson et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A Randomized, Double-Blind, Placebo-Controlled Trial of Spironolactone on Carotid Intima-Media Thickness in Nondiabetic Hemodialysis Patients

(2010) A. Vukusich et al.   Clinical Journal of the American Society of Nephrology

11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium inApoe−/−Mice

(2010) Graeme A. Deuchar et al.   ENDOCRINOLOGY

Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

(2010) Alexander W. Krug et al.   HYPERTENSION

Placental growth factor mediates aldosterone-dependent vascular injury in mice

(2010) Iris Z. Jaffe et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human IL-8 Regulates Smooth Muscle Cell VCAM-1 Expression in Response to Endothelial Cells Exposed to Atheroprone Flow

(2009) Nicole E. Hastings et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions

(2009) C. Roncal et al.   CARDIOVASCULAR RESEARCH

Blood pressure control in the elderly: Can you have too much of a good thing?

(2009) David J. Hyman et al.   CURRENT HYPERTENSION REPORTS

Role of Angiotensin II Type 1 Receptor Antagonists in the Treatment of Hypertension in Patients Aged ≥65 Years

(2009) Alan H. Gradman   DRUGS & AGING

Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells

(2009) Bradley A. Maron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Aldosterone Signaling and Vascular Reactivity: Relax or Donʼt Do It

(2009) Jane A Leopold   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

Complex Regulation and Function of the Inflammatory Smooth Muscle Cell Phenotype in Atherosclerosis

(2009) Anthony Wayne Orr et al.   JOURNAL OF VASCULAR RESEARCH

Angiotensin receptors as determinants of life span

(2009) Paola Cassis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src-Regulated Redox-Sensitive RhoA Pathways

(2008) A.C. Montezano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism

(2008) Giampaolo Bernini et al.   JOURNAL OF HYPERTENSION

Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology

(2008) John W. Funder et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY