Article
Neurosciences
Alejandro Torrado Pacheco, Juliet Bottorff, Ya Gao, Gina G. Turrigiano
Summary: Homeostatic plasticity can bidirectionally regulate neuronal firing rates around a stable set point, and downward firing rate homeostasis (FRH) does not require NMDAR signaling and occurs during sleep.
Article
Multidisciplinary Sciences
Tomoko Yamagata, Martin C. Kahn, Jose Prius-Mengual, Elise Meijer, Merima Sabanovic, Mathilde C. C. Guillaumin, Vincent van der Vinne, Yi-Ge Huang, Laura E. McKillop, Aarti Jagannath, Stuart N. Peirson, Edward O. Mann, Russell G. Foster, Vladyslav V. Vyazovskiy
Summary: The inhibitory neurons in the lateral preoptic area (LPO) of the hypothalamus play a role in regulating arousal levels, impacting both the quality of sleep and the accumulation of sleep pressure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Andrey Kostin, Md Aftab Alam, Dennis McGinty, Md Noor Alam
Summary: Adult neurogenesis in the hypothalamus plays a crucial role in regulating functions such as sleep-wake cycles, but declines with aging, potentially contributing to sleep-wake disturbances. Stimulating endogenous neural stem cells in hypothalamic neurogenic niches may be a promising approach to mitigate hypothalamic dysfunctions in aging.
Article
Biochemical Research Methods
Quinton M. Skilling, Bolaji Eniwaye, Brittany C. Clawson, James Shaver, Nicolette Ognjanovski, Sara J. Aton, Michal Zochowski
Summary: Sleep plays a critical role in memory consolidation, with neuromodulatory changes mediating the process. During NREM sleep, there is a remapping of neural firing order based on previous wake firing rates, mediated by ACh-gated potassium current. Learning-dependent reordering of firing rates during NREM sleep can reconfigure neuronal firing patterns across the network, ultimately biasing neural networks towards phase-based information encoding for memory consolidation.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biology
Jyoti Tiwari, Sayantan Sur, Anupama Yadav, Raj Kumar, Niraj Rai, Sangeeta Rani, Shalie Malik
Summary: The study investigated the molecular regulation of sleep in migratory redheaded buntings. It was found that during migration, there was increased night-time activity and reduced daytime activity. The recordings showed increased night-time active wakefulness with reduced sleep during migratory phase. Gene expression studies revealed increased expression of glucocorticoid receptor and pro-inflammatory cytokines in pre-migratory and migratory states, and upregulation of Ca2+/calmodulin-dependent protein kinase 2 in the migratory state. Melatonin receptors were increased in the pre-migratory state, while growth hormone-releasing hormone was reduced during migration.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Audiology & Speech-Language Pathology
J. A. Cook, K. M. Barry, J. W. Zimdahl, K. Leggett, W. H. A. M. Mulders
Summary: Research suggests that in guinea pigs with tinnitus, there is a significant increase in the spontaneous firing rate of pure-tone responsive neurons in the medial geniculate nucleus, while burst firing parameters remain unchanged. Monitoring physiological status is crucial for obtaining reliable data when recording at higher levels of the auditory pathway.
Review
Pharmacology & Pharmacy
Gratia Nguyen, Svetlana Postnova
Summary: General anaesthesia is widely used in surgery and interventional medical procedures, and computational modelling has provided valuable insights into the neural circuitry involved in generating unconsciousness from administering an anaesthetic drug. Current research focuses on the EEG features under GABAergic anaesthetic drugs in the brain activity, proposing theories for the origin of these features. Recent empirical findings suggest that anaesthetic drugs may act directly on the hypothalamic neural circuitry, which regulates sleep-wake states and circadian rhythms.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Dhanush Haspula, Zhenzhong Cui
Summary: Precise neural regulation is essential for maintaining energy homeostasis. Hypothalamic and brainstem nuclei adjacent to the circumventricular organs play important roles in regulating energy balance. These nuclei receive inputs from other brain regions and circulating signals, allowing them to exert multi-tier control over metabolism. This review focuses on summarizing the mechanisms by which different neuronal subpopulations in the hypothalamus and brainstem regulate key metabolic functions.
Article
Multidisciplinary Sciences
Roberto De Luca, Stefano Nardone, Kevin P. Grace, Anne Venner, Michela Cristofolini, Sathyajit S. Bandaru, Lauren T. Sohn, Dong Kong, Takatoshi Mochizuki, Bianca Viberti, Lin Zhu, Antonino Zito, Thomas E. Scammell, Clifford B. Saper, Bradford B. Lowell, Patrick M. Fuller, Elda Arrigoni
Summary: This study investigates the mechanisms by which orexin neurons contribute to arousal maintenance and state stability through silencing sleep-promoting neurons. The findings provide alternate insights into the role of orexin neurons in maintaining wakefulness.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Tatiana D. Viena, Robert P. Vertes, Stephanie B. Linley
Summary: The nucleus reuniens (RE) is strongly connected with the hippocampus and medial prefrontal cortex, playing a critical role in affective and cognitive functioning. Studies on behaving rats showed heterogeneity in discharge properties of RE neurons across sleep-wake states, with most cells exhibiting state-related changes and classified into distinct cell types. The diverse set of RE neurons are likely modulated by key brainstem and hypothalamic nuclei, influencing waking and REM sleep activities in cortical targets.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Chemistry, Medicinal
Eric Murillo-Rodriguez, Cristina Carreon, Mario Eduardo Acosta-Hernandez, Fabio Garcia-Garcia
Summary: This article reviews the role of stimulants and depressor compounds in sleep regulation and discusses the neurobiological mechanisms involved.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Psychiatry
Christopher W. Thomas, Cristina Blanco-Duque, Benjamin J. Breant, Guy M. Goodwin, Trevor Sharp, David M. Bannerman, Vladyslav V. Vyazovskiy
Summary: Serotonergic psychedelic drugs, such as psilocin, affect sleep and vigilance state by delaying REM sleep onset, reducing NREM sleep maintenance, and enhancing 4 Hz cortical oscillation. However, these drugs do not significantly affect sleep-wake quantity and sleep recovery following sleep deprivation. Nevertheless, psilocin inhibits the recovery rate of sleep slow-wave activity in specific areas.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jose Manuel Duhart, Sho Inami, Kyunghee Koh
Summary: The two-process model of sleep regulation has been a dominant conceptual framework for sleep research. In addition to the circadian and homeostatic processes, sleep is influenced by various factors such as essential behaviors, sensory inputs, and memory consolidation.
Article
Clinical Neurology
Siobhan Banks, Christopher W. Jones, Mark E. Mccauley, Jillian Dorrian, Mathias Basner, Greg Maislin, Hans P. A. Van Dongen, David F. Dinges
Summary: This laboratory study investigates the dynamics of neurobehavioral impairment caused by chronic sleep restriction. The experiment involves two periods of sleep restriction, with a 1-day dose-response intervention sleep opportunity in between. The results show that the neurobehavioral impairment accumulates across the two sleep restriction periods, and the intervention sleep opportunity has only a slight and short-lived effect. The findings highlight the profound and enduring influence of long-term sleep-wake history on the neurobehavioral response to sleep loss.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lei Li, Meng-Qi Zhang, Xiao Sun, Wen-Ying Liu, Zhi-Li Huang, Yi-Qun Wang
Summary: Good sleep quality is essential for maintaining attention during wakefulness. Through experiments on mice, it was found that gamma-aminobutyric acid (GABA)ergic neurons in the dorsomedial hypothalamus (DMH) play an important role in regulating sleep-wake behaviors in response to changes in ambient temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Babak Khodaie, Ahmad Ali Lotfinia, Milad Ahmadi, Mahmoud Lotfinia, Maryam Jafarian, Fariba Karimzadeh, Philippe Coulon, Ali Gorji
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Pharmacology & Pharmacy
Manuela Cerina, Hanna J. Szkudlarek, Philippe Coulon, Patrick Meuth, Tatyana Kanyshkova, Xuan Vinh Nguyen, Kerstin Goebel, Thomas Seidenbecher, Sven G. Meuth, Hans-Christian Pape, Thomas Budde
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Cell Biology
Christina Neyer, David Herr, Denise Kohmann, Thomas Budde, Hans-Christian Pape, Philippe Coulon
Article
Neurosciences
Denise Kohmann, Annika Luettjohann, Thomas Seidenbecher, Philippe Coulon, Hans-Christian Pape
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Review
Pharmacology & Pharmacy
Philippe Coulon, Ali Gorji
TRENDS IN PHARMACOLOGICAL SCIENCES
(2016)
Review
Neurosciences
Philippe Coulon, Carole E. Landisman
Article
Clinical Neurology
Sven G. Meuth, Kerstin Goebel, Tatyana Kanyshkova, Petra Ehling, Martin A. Ritter, Wolfram Schwindt, Martina Bielaszewska, Pia Lebiedz, Philippe Coulon, Alexander M. Herrmann, Wiebke Storck, Denise Kohmann, Johannes Muething, Hermann Pavenstaedt, Tanja Kuhlmann, Helge Karch, Georg Peters, Thomas Budde, Heinz Wiendl, Hans-Christian Pape
ANNALS OF NEUROLOGY
(2013)
Article
Biology
Ednan Gerard, Peter Hochstrate, Paul-Wilhelm Dierkes, Philippe Coulon
JOURNAL OF EXPERIMENTAL BIOLOGY
(2012)
Article
Neurosciences
Fariba Karimzadeh, Maryam Jafarian, Marzieh Gharakhani, Soodeh Razeghi Jahromi, Elham Mohamadzadeh, Behzad Khallaghi, Peir Hossein Kolivand, Hadi Kazemi, Philippe Coulon, Ali Gorji
NUTRITIONAL NEUROSCIENCE
(2013)
Article
Physiology
Petra Ehling, Manuela Cerina, Patrick Meuth, Tatyana Kanyshkova, Pawan Bista, Philippe Coulon, Sven G. Meuth, Hans-Christian Pape, Thomas Budde
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2013)
Article
Multidisciplinary Sciences
Gesche Born, Dorothee Breuer, Shaopeng Wang, Astrid Rohlmann, Philippe Coulon, Puja Vakili, Carsten Reissner, Friedemann Kiefer, Martin Heine, Hans-Christian Pape, Markus Missler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Jan Deubner, Philippe Coulon, Ilka Diester
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2019)
Article
Biochemical Research Methods
David Eriksson, Megan Schneck, Artur Schneider, Philippe Coulon, Ilka Diester
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Review
Biochemical Research Methods
Brice De La Crompe, Philippe Coulon, Ilka Diester
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Meeting Abstract
Physiology
M. Cerina, H. Szkudlarek, T. Kanyshkowa, P. Meuth, K. Goebel, P. Coulon, S. G. Meuth, C. Pape, T. Budde