Article
Medicine, General & Internal
Ke Qian, Jie Tang, Yue-Juan Ling, Ming Zhou, Xin-Xin Yan, Yu Xie, Lu-Jia Zhu, Koju Nirmala, Kang-Yun Sun, Zheng-Hong Qin, Rui Sheng
Summary: NADPH exhibits positive inotropic effects and improves energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure.
Article
Multidisciplinary Sciences
Shouyan Fan, Lingfeng Gao, Annie Christel Bell, Joseph Akparibila Azure, Yang Wang
Summary: Force enhancement in cardiac muscles can cause muscle decompensation and affect the development of diastolic dysfunction. The synchronization of force enhancement with intracellular Ca2+ transfer leads to a reduction in tension-time integral.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Andrew O. Jo, Monika Lakk, Christopher N. Rudzitis, David Krizaj
Summary: This study reveals that Muller glia cells are mechanosensitive and their response to tensile loading is mediated through the activation of TRPV4 and TRPC1 channels.
Article
Cardiac & Cardiovascular Systems
Alexandra Rhoden, Thomas Schulze, Niels Pietsch, Torsten Christ, Arne Hansen, Thomas Eschenhagen
Summary: The study found that the effects of OM on contractility and diastolic tension are complex and influenced by concentration, time, species, and loading conditions. Further research is needed to explore the effects on mitochondrial function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Melissa J. Bukowski, Benjamin Cavanaugh, Anita Abbo, Charles S. Chung
Summary: Diastolic dysfunction is a common phenotype in cardiovascular diseases. Modifying the strain rate of a stretch, rather than blood pressure, can modify the subsequent relaxation rate of myocardial tissue. The mechanical control of relaxation (MCR) can be assessed using intact cardiac trabeculae and may provide new approaches for the treatment of heart failure.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Physiology
Zeynep Melike Isilay Zeybek, Vittorio Racca, Antonio Pezzano, Monica Tavanelli, Marco Di Rienzo
Summary: Cardiac mechanics can be derived from cardiac time intervals, traditionally estimated by ultrasound techniques. However, specific fiducial points in the waveform of the seismocardiogram can also be used for assessment. This study found that not every cardiac patient has an SCG waveform suitable for CTI estimation, thus a preliminary check is advisable before using SCG-based monitoring.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jie Gao, Guanyin Yuan, Zhan Xu, Luyao Lan, Wenkuan Xin
Summary: Bile acids, endogenous steroids derived from cholesterol metabolism, may be involved in cardiopathy of cholestatic liver diseases. Chenodeoxycholic acid and deoxycholic acid are associated with colon cancer, gallstones, and gastrointestinal disorders, while their effects on the heart are less understood. Experimental findings suggest that these bile acids exhibit positive inotropic effects and negative chronotropic effects on rat hearts.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ilaria Stadiotti, Rosaria Santoro, Alessandro Scopece, Sergio Pirola, Anna Guarino, Gianluca Polvani, Angela Serena Maione, Flora Ascione, Qingsen Li, Domenico Delia, Marco Foiani, Giulio Pompilio, Elena Sommariva
Summary: The study reveals that persistent pressure overload in patients with severe aortic stenosis and HFpEF-like syndrome leads to DNA damage and activation of DNA damage response (DDR) not only in cardiomyocytes but also in cardiac stromal cells. In cardiac stromal cells, DDR activation promotes inflammation and fibrosis, which can be prevented by specific DDR targeting.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Irene Lucia Ennis, Nestor Gustavo Perez
Summary: Current evidence suggests that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays a crucial physiological role, while clinical evidence indicates a detrimental role in severe cardiac diseases like congestive heart failure. Recent discoveries on locally triggered cardiac MR signals shed light on its potential physiological and pathological consequences in the heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Anatomy & Morphology
Leslie Donoghue, Caleb Graham, Palaniappan Sethu
Summary: This study aimed to create a system to subject engineered cardiac tissue to specific hemodynamic stresses and evaluate acute tissue remodeling. The results confirmed that both pressure and stretch mediate acute stress responses in the engineered cardiac tissue.
CELLS TISSUES ORGANS
(2023)
Article
Cell Biology
Hiroshi Matsuura, Akiko Kojima, Yutaka Fukushima, Yu Xie, Xinya Mi, Ravshan Z. Sabirov, Yasunobu Okada
Summary: The study found that endogenous ATP released through Maxi-Cl channels has a significant impact on the left ventricular contractile function of Langendorff-perfused mouse hearts, contributing to the transient positive inotropy observed during reperfusion after short-term hypoxia/ischemia in the heart.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Diego Candia-Rivera, Vincenzo Catrambone, Julian F. Thayer, Claudio Gentili, Gaetano Valenza
Summary: The century-long debate on bodily states and emotions continues, with this study investigating the brain-heart interplay during emotional experiences. Using a computational model, the researchers found that sympathetic-vagal activity plays a leading and causal role in initiating the emotional response, and the subsequent dynamic interplay between the central and autonomic nervous systems sustains the processing of emotional arousal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Anatomy & Morphology
Yin He, Zhifu Sun, Xiaonan He, Yuhong Mi
Summary: Patients with long-lasting hypertension often suffer from atrial or ventricular arrhythmias. A short-term increase in blood pressure leads to a rise in tachyarrhythmias in patients with hypertension. The increased stiffness of ventricular myocytes caused by hypertension leads to hypersensitivity of cellular calcium flow to mechanical stimuli, which is one of the mechanisms that cause arrhythmias. This study provides new techniques and ideas for developing new anti-arrhythmic drugs.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Cardiac & Cardiovascular Systems
Nikolaos Makris, Georgios Georgiopoulos, Aggeliki Laina, Maria-Eirini Tselegkidi, Despoina Fotiou, Nikolaos Kanellias, Evaggelos Eleftherakis-Papaiakovou, Magda Migkou, Eleni Dimitra Papanagnou, Konstantinos Katogiannis, Ioannis Petropoulos, Hector Anninos, Dimitrios Bampatsias, Eleni Maneta, Elisabeth Samouilidou, Dimitris Nikas, Giorgia Ciliberti, Konstantinos Stellos, Evaggelos Terpos, Maria Gavriatopoulou, Ioannis P. Trougakos, Ignatios Ikonomidis, Meletios-Athanasios Dimopoulos, Efstathios Kastritis, Kimon Stamatelopoulos
Summary: This study aimed to investigate the effect of proteasome inhibition on myocardial mechanics and found that inhibition of the ubiquitin-proteasome system led to global deterioration of cardiac function, which was also associated with cardiotoxicity.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Pediatrics
Xiuxia Ye, Shumei Dong, Yujiao Deng, Chuan Jiang, Yanting Kong, Lili Tang, Yanlin Wang, Fei Bei, Haifa Hong
Summary: This study found that vitamin D deficiency in pediatric patients before cardiac surgery is associated with the need for increased postoperative inotropic support at 24 hours post operation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Simon-Chica, Marbely C. Fernandez, Eike M. Wuelfers, Achim Lother, Ingo Hilgendorf, Gunnar Seemann, Ursula Ravens, Peter Kohl, Franziska Schneider-Warme
Summary: This study characterized the electrophysiological properties of cardiac resident MΦ in mice and explored their potential impact on cardiomyocytes. The research findings provide insights into the involvement of MΦ in cardiac conduction and pave the way for further understanding their role in the heart.
CARDIOVASCULAR RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Oleg Lookin, Daniil Kuznetsov, Yuri Protsenko
Summary: The cardiac-specific myosin activator omecamtiv mecarbil has differential effects on active force and Ca2+ kinetics in healthy and diseased myocardium, with the higher concentration showing significant suppression of active tension-length relationships in healthy rats but not in rats with heart failure. This suggests that the drug may have different impacts on cardiac function depending on the underlying health of the myocardium.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Editorial Material
Neurosciences
Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cell Biology
Joachim Greiner, Teresa Schiatti, Wenzel Kaltenbacher, Marica Dente, Alina Semenjakin, Thomas Kok, Dominik J. Fiegle, Thomas Seidel, Ursula Ravens, Peter Kohl, Remi Peyronnet, Eva A. Rog-Zielinska
Summary: Freshly isolated primary cardiomyocytes (CM) are essential for cardiac research, but their short viability limits their use. This study presents a method of multi-day CM isolation, which prolongs cell viability and allows for exploration of regional differences in the heart.
Article
Biochemistry & Molecular Biology
Oleg Lookin, Elena Mukhlynina, Yuri Protsenko
Summary: There is a lack of data about the contractile behavior of the right atrial myocardium in chronic pulmonary heart disease. In this study, we found noticeable differences in the contractility and Ca transient of isolated right atrial strips between healthy rats and rats with monocrotaline-induced pulmonary hypertension, suggesting a potential compensatory effect of atrial myocardium in systolic deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Svetlana Klinova, Ilzira A. Minigalieva, Yuri L. Protsenko, Marina P. Sutunkova, Vladimir B. Gurvich, Julia Ryabova, Irene E. Valamina, Oksana P. Gerzen, Salavat R. Nabiev, Alexander A. Balakin, Oleg N. Lookin, Ruslan Lisin, Daniil A. Kuznetsov, Larisa Privalova, Vladimir G. Panov, Leonid B. Katsnelson, Larisa Nikitina, Boris A. Katsnelson
Summary: This study found that exercise can attenuate the damage caused by lead intoxication on the cardiovascular system. Rats injected with lead and forced to exercise showed normalization of calcium levels and angiotensin-converting enzyme activity in the blood serum, improvement in electrocardiogram indicators, increased creatine kinase-MB levels, and decreased respiratory rate. Furthermore, the sliding velocity of regulated thin filaments and myosin heavy chain ratio were partly normalized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Peter Kohl, Joachim Greiner, Eva A. Rog-Zielinska
Summary: This Review discusses the latest insight into the 3D nanostructure of the heart and its impact on cellular function during contraction and relaxation. Technological breakthroughs in biological sample preparation, 3D imaging, and data analysis have provided access to new data and driven the development of smart image-analysis algorithms. The authors highlight the scientific discovery and potential clinical relevance of understanding 3D cardiac nanodynamics, as well as predict further progress in the next decade.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Physiology
Oleg Lookin, Anastasia Khokhlova, Tatiana Myachina, Xenia Butova, Olivier Cazorla, Pieter de Tombe
Summary: There are transmural differences in sarcomere length distribution between subepi- and subendocardial cardiomyocytes, and the intracellular variability in sarcomere length is affected by the state of contraction.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Neurosciences
T. Alexander Quinn, Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Oleg Lookin, Pieter de Tombe, Najlae Boulali, Csilla Gergely, Thierry Cloitre, Olivier Cazorla
Summary: Cardiomyocyte sarcomere length variability can be accurately assessed using second-harmonic generation microscopy, which provides a direct visualization of A-band sarcomeric structures. This method allows for a more precise evaluation of sarcomere length variability compared to confocal fluorescence microscopy. It has the potential to be a valuable tool for studying sarcomere variability in both in vitro and in vivo conditions, and its role in the functional behavior of living myocardium.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oleg Lookin, Alexander Balakin, Yuri Protsenko
Summary: The differences in contractility regulation and calcium handling between atrial and ventricular myocardium were poorly studied. This study found that the right atrial muscles were stiffer, faster, and weaker in active force compared to the right ventricular muscles. The length-dependent effects and passive/active force relationships were similar in both muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Neurosciences
Yoshihiro Kubo, Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cardiac & Cardiovascular Systems
Ana Simon-Chica, Eike M. Wuelfers, Peter Kohl
Summary: This review provides an overview of heterocellular electrical communication in the heart, highlighting the roles of cardiac fibroblasts and macrophages in cardiac electrophysiology and arrhythmogenesis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Physiology
Oleg Lookin, Najlae Boulali, Olivier Cazorla, Pieter de Tombe
Summary: The contractility of cardiac muscle is strongly influenced by preload through the Frank-Starling mechanism. Recent findings indicate that sarcomere length in resting cardiomyocytes displays natural variability that is altered during active contraction. However, it is still unknown whether the change in sarcomere length variability is regulated by the activation process or changes in overall cell stretch.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
O. Lookin, Y. Protsenko
Summary: The Slow Force Response (SFR) is an important mechanism for myocardial contractility adaptation. The discrepancies between atrial and ventricular SFR and the correlation between mechanical response and Ca2+ transient changes are poorly characterized. Our study found that the extent of SFR was higher in failing myocardium, and the changes in Ca2+ transient characteristics were smaller compared to the extent of SFR.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2022)
