Article
Medical Laboratory Technology
Kun-Lin Wu, Che-Yi Chou, Hui-Yin Chang, Chih-Hsun Wu, An-Lun Li, Chien-Lung Chen, Jen-Chieh Tsai, Yi-Fan Chen, Chiung-Tong Chen, Chin-Chung Tseng, Jin-Bor Chen, I-Kuan Wang, Yu-Juei Hsu, Shih-Hua Lin, Chiu-Ching Huang, Nianhan Ma
Summary: This study developed a novel noninvasive miRNA test for diagnosing EPS. By screening miRNA profiles and combining clinical characteristics, machine learning models were able to accurately predict the occurrence of EPS.
CLINICA CHIMICA ACTA
(2022)
Article
Veterinary Sciences
So-Jeong Nam, Sun-Hye Song, Seung-Hyun Lee, So-Young Jeung, Jae Gon Ah, Su-Hyung Lee, Min-Ok Ryu
Summary: A 13-year-old neutered male Korean short-hair cat presented with symptoms of anorexia, lethargy, and severe abdominal distension. After a series of tests, it was diagnosed with sclerosing peritoneal carcinomatosis, a rare condition characterized by peritoneal thickening, fat stranding, and calcification.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Transplantation
Mitsuhiro Tawada, Yasuhiko Ito, Masataka Banshodani, Masahiro Yamashita, Sadanori Shintaku, Ting Sun, Yasuhiro Suzuki, Hiroshi Kinashi, Yoko Kubo, Masahiko Ando, Makoto Yamaguchi, Takayuki Katsuno, Masashi Mizuno, Hideki Kawanishi
Summary: The study found that patients in the conventional PD solution group had less angiogenesis but more severe vasculopathy, while those in the pH-neutral solution group had milder vasculopathy. The L/V ratio was significantly associated with the relapse rate of EPS.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Kanako Watanabe-Kusunoki, Yoshihiro Kusunoki, Junichi Goto, Kazutaka Kukita
Summary: A case of advanced liver cirrhosis with end-stage renal disease (ESRD) developed encapsulating peritoneal sclerosis (EPS) after 4 years of peritoneal dialysis (PD), and was successfully recovered by surgery.
Article
Medicine, General & Internal
Yongwang Hou, Weidong Zhao, Zhicong Yang, Bin Zhang
Summary: This study aims to investigate SAA and IL-6 as potential diagnostic biomarkers for gastric cancer, and finds that these two markers are closely related to the severity and prognosis of GCa.
Review
Urology & Nephrology
Shingai Pepereke, Ankur D. Shah, Edwina A. Brown
Summary: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome characterized by the formation of fibrous encapsulation around the abdominal organs, leading to increased morbidity and mortality. While most patients undergoing peritoneal dialysis (PD) will not develop EPS, risk factors include duration of PD, peritonitis, and discontinuation of PD. Due to its rarity, knowledge of EPS is mostly based on case series and registries, and treatment methods are extrapolated from low-quality evidence. Malnutrition plays a significant role in mortality, emphasizing the importance of nutritional support in management.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Hematology
Yaxuan Fang, Xin Chen, Ke Zhong, Qingying Ni, Zhenyang He, Yanheng Qiao, Yanru Zhao, Jie Li, Hongtao Yang, Bo Yang
Summary: Encapsulating peritoneal sclerosis (EPS) is a rare and harmful complication that can lead to destructive outcomes. Matrix metalloproteinase-2 (MMP-2), as a protease, plays a crucial role in the progression of EPS by reducing constituents of the extracellular matrix. As a new biomarker, MMP-2 may enhance the detection rate of EPS patients in clinical practice. This review summarizes the recent studies on MMP-2 in different etiologies, assesses its application value, and highlights future directions.
BLOOD PURIFICATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Xue Yu, Lu Yan, Xin Li, Anqi Duan, Chenhong An, Xiuping Ma, Changming Xiong, Qin Luo, Zhihong Liu
Summary: The study demonstrated that CA 125 levels are associated with clinical, echocardiographic, hemodynamic parameters, and prognosis in patients with pulmonary hypertension. Higher CA 125 levels were linked to worse disease progression and prognosis among pulmonary hypertension patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Chemistry, Analytical
Mehrab Pourmadadi, Ali Moammeri, Amin Shamsabadipour, Yasamin Farahanian Moghaddam, Abbas Rahdar, Sadanand Pandey
Summary: Diagnosing early-stage cancers is crucial for saving lives and reducing mortality rates. Detection of the cancer antigen CA-125 is a key step in the treatment of certain cancers, such as ovarian cancer. This review discusses various optical and electrochemical methods for detecting CA-125, compares their performance and sensitivity, investigates commercial detection kits, and evaluates their applicability and accuracy.
Article
Medicine, General & Internal
Jin Long Liang, Zheng Quan Chen, Zhang Yi, Wen Kun Ming
Summary: This article reports a rare case of encapsulating peritoneal sclerosis (EPS) with intestinal obstruction following cesarean section. Intestinal obstruction caused by EPS lacks specificity and presents challenges in diagnosis and treatment. Surgery is an effective treatment for this condition.
Article
Urology & Nephrology
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study found that the combination therapy of PD and once-weekly hemodialysis is associated with lower infection-related mortality but not with a lower incidence of EPS in the short term. Patients on combination therapy had a decreasing D/P Cr ratio over time, while those on PD alone had an increasing ratio.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Augustine Joshua Devasahayam, Liam Patrick Kelly, John Bradley Williams, Craig Stephen Moore, Michelle Ploughman
Summary: The study found that individuals with higher fitness levels in progressive MS tend to show a shift towards a repair phenotype, with higher levels of IL-6. Progressive MS patients had significantly lower maximal oxygen consumption, and higher (V)over dotO(2max) was associated with a shift in the balance of blood biomarkers towards a repair phenotype from inflammation.
Article
Medicine, General & Internal
Kensei Taguchi, Yuta Mitsuishi, Sakuya Ito, Tomofumi Moriyama, Kei Fukami
Summary: Glucocorticoids may mask peritoneal inflammation in patients undergoing peritoneal dialysis, leading to the development of encapsulating peritoneal sclerosis.
Article
Biochemistry & Molecular Biology
Anca Cardoneanu, Alexandra Maria Burlui, Luana Andreea Macovei, Ioana Bratoiu, Patricia Richter, Elena Rezus
Summary: Systemic sclerosis (SS) is a chronic autoimmune disorder characterized by cutaneous and systemic clinical manifestations. Interleukin-6 (IL-6) plays a critical role in the development of vascular damage and fibrosis in SS. Tocilizumab, an anti-IL-6 therapy, shows promising results in improving skin and lung damage in SS patients.
Article
Multidisciplinary Sciences
Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakano
Summary: Peritoneal calcification is a prominent characteristic of the later stage of encapsulating peritoneal sclerosis in patients on long-term peritoneal dialysis. This study found that calcifying medium accelerates peritoneal cell calcification, which can be prevented by magnesium supplementation.
SCIENTIFIC REPORTS
(2023)
Review
Urology & Nephrology
Alena Parikova, Kristyna Michalickova, Anouk T. N. van Diepen, Ludek Voska, Ondrej Viklicky, Raymond T. Krediet
Summary: Several studies have shown that low glucose degradation product neutral pH dialysis solutions can mitigate and delay peritoneal alterations compared to conventional solutions, emphasizing better mesothelial preservation and reduced functional changes.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Rheumatology
Elke Theodora Antonia Maria van Delft, Deirisa Lopes Barreto, Annette Helena Maria van der Helm-van Mil, Celina Alves, Johanna Maria Wilhelmina Hazes, Tjallingius Martijn Kuijper, Angelique Elisabeth Adriana Maria Weel-Koenders
Summary: The aim of this study was to evaluate the performance of the REACH and CARE referral rules in diagnosing inflammatory arthritis and IRD in a primary care population. The results showed that CARE had a higher area under the curve compared to REACH and had greater clinical value compared to usual care. Additionally, the composite referral rule for IRD using 10 parameters also demonstrated good diagnostic performance.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Urology & Nephrology
Raymond T. Krediet, Deirisa Lopes Barreto, Anouk T. N. van Diepen
Summary: This study focused on the transport of serum proteins to peritoneal dialysate in peritoneal dialysis patients, specifically individual proteins. The researchers determined the concentrations of four individual proteins with different molecular weights in the serum and effluent of the patients. The results showed that the transport of these proteins depended on their molecular weight and diffusion coefficient. The peritoneal protein restriction coefficient (PPRC), which represents the size restriction to transport, was developed based on the relationship between the clearances of these proteins and their diffusion coefficients. Long-term follow-up of patients revealed an increase in PPRC, possibly due to venous vasculopathy of the peritoneal microcirculation.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Review
Urology & Nephrology
Raymond T. Krediet, Alena Parikova
Summary: Long-term peritoneal dialysis can cause alterations in peritoneal function, such as high small solute transfer rates and impaired ultrafiltration, which are driven by peritoneal inflammation. A new hypothesis suggests that high glucose-induced pseudohypoxia plays a role in the development of these alterations. The high NADH-NAD1 ratio induced by glucose upregulates the expression of various profibrotic genes, leading to peritoneal fibrosis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Physiology
Raymond T. Krediet
Summary: This review summarizes the structural and functional alterations of the peritoneal dialysis membrane caused by long-term peritoneal dialysis, and discusses the pseudohypoxia hypothesis and glucose-induced conditions as explanations for these alterations. The upregulation of GLUT-1 in interstitial fibroblasts is highlighted as a key factor in ultrafiltration failure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Rheumatology
Marijke van den Dikkenberg, Nathalie Luurssen-Masurel, Tjallingius Martijn Kuijper, Marc-Redwart Kok, Johanna Maria Wilhelmina Hazes, Pascal Hendrik Pieter de Jong, Deirisa Lopes-Barreto, Angelique Elisabeth Adriana Maria Weel-Koenders
Summary: This systematic review aims to evaluate the effects of disease-modifying antirheumatic drugs (DMARDs) on patient-reported outcomes in rheumatoid arthritis. The results showed that DMARDs reduce the burden of pain, fatigue, and activity limitation compared to placebo and methotrexate.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
E. T. A. M. van Delft, D. Lopes Barreto, K. H. Han, I Tchetverikov, A. Evertse, T. M. Kuijper, J. M. W. Hazes, A. E. A. M. Weel-Koenders
Summary: Introducing rheumatologists for triaging in primary care improves the accuracy of referrals, reduces healthcare utilization, and improves patient quality of life.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Review
Medicine, General & Internal
E. T. A. M. van Delft, Maha Jamal, Hannah den Braanker, T. M. Kuijper, J. M. W. Hazes, Deirisa Lopes Barreto, A. E. A. M. Weel-Koenders
Summary: This study aims to evaluate whether the incidence of rheumatoid arthritis has increased after the introduction of the updated ACR/EULAR classification criteria. A systematic review found that the incidence of rheumatoid arthritis has increased over time since the implementation of the new criteria. However, due to significant heterogeneity among the included studies, no definitive conclusions can be drawn regarding this time effect.
FRONTIERS IN MEDICINE
(2022)
Article
Economics
Fiona Koster, Marc R. Kok, Jaco van der Kooij, Geeke Waverijn, Angelique E. A. M. Weel-Koenders, Deirisa Lopes Barreto
Summary: Time-driven activity-based costing (TDABC) using fuzzy logic (FL-TDABC) provides a more precise and efficient estimate of healthcare cycle costs, considering the subjective nature of time estimates. The FL-TDABC methodology estimated the annual costs of the rheumatoid arthritis (RA) care cycle to be euro1497 per patient, with a 22% cost variation. The main cost drivers were consultations with rheumatologists and pharmacy costs. FL-TDABC offers insights for transitioning from a volume-based system to a value-based healthcare (VBHC) system.
PHARMACOECONOMICS-OPEN
(2023)
Article
Rheumatology
M. Jamal, T. M. Kuijper, J. M. W. Hazes, D. Lopes Barreto, A. E. A. M. Weel
Summary: This study assessed the cost-utility of the digital CaFaSpA referral strategy for axSpA in primary care patients with CLBP. The results showed that the CS group had lower total costs and did not decrease the overall healthcare status of patients, indicating that CS is a cost-effective primary care referral model.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Fiona Koster, Pieter L. H. Bakx, Marc R. Kok, Deirisa Lopes Barreto, Angelique E. A. M. Weel-Koenders
Summary: The prevalence of multimorbidity is increasing among patients with rheumatoid arthritis (RA) and is associated with worse outcomes. This study examines the importance of a multidisciplinary, integrated approach in managing multimorbid patients and assesses the association between expenditures and multimorbidity using real-life data.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Rheumatology
Maha Jamal, Elke Theodora Antonia Maria van Delft, Hannah den Braanker, Tjallingius Martijn Kuijper, Johanna Mieke Wilhelmina Hazes, Deirisa Lopes Barreto, Angelique Elisabeth Adriana Maria Weel
Summary: This study aimed to investigate the proportion of axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) diagnoses among newly referred patients visiting rheumatology outpatient clinics, as well as the impact of ASAS and CASPAR classification criteria. The study found that the proportion of newly referred patients with axSpA was 19% and with PsA was 18%. However, due to high heterogeneity, the findings should be interpreted with caution.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Fiona Koster, Deirisa Lopes Barreto, Sandhya C. Nair, Marc R. Kok, Angelique E. A. M. Weel-Koenders
Summary: The study aimed to establish a validated process map of the care cycle for patients with Rheumatoid Arthritis (RA) in order to improve the quality of care and identify areas for improvement. By systematically documenting activities and resources and conducting interviews with medical staff, a comprehensive process map was created. This approach increased transparency, optimized care delivery, and resulted in improvement actions on both outcome and process levels.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Primary Health Care
Elke van Delft, Ruben Bos, Patricia Pennings, Mieke Hazes, Deirisa Lopes Barreto, Angelique Weel-Koenders
Summary: This study aims to understand the context of implementing a digital referral algorithm and explore the potential barriers and facilitators to implementation. Both patients and caregivers recognize the need for early referral and perceive the benefits of the digital algorithm. However, the complexity of the currently included questions and the lack of information on managing no risk of IRD are potential barriers. In order for successful implementation, the inclusivity, accessibility, content, and outcome of the algorithm are considered important themes.