Article
Immunology
Qi Chen, Hao Li, Yusi Liu, Min Zhao
Summary: This study comprehensively analyzed the epigenetic regulation in rheumatoid arthritis (RA) using differential analysis and cross-analysis. The results identified differentially methylated sites, differentially expressed genes, and differentially expressed miRNAs associated with RA. A comprehensive epigenetic regulatory network was constructed, and core regulatory genes were identified. This study provides a new direction for future research on the epigenetic mechanisms of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Yingyi Chen, Siyan Liu, Lili Wu, Yitong Liu, Juan Du, Zhenhua Luo, Junji Xu, Lijia Guo, Yi Liu
Summary: Appropriate responses to inflammation are important for pathogen elimination and tissue repair, while uncontrolled inflammation can lead to tissue damage. CCL2, a chemokine and activator of monocytes, macrophages, and neutrophils, plays a key role in amplifying and accelerating the inflammatory cascade and is closely related to chronic non-controllable inflammation. Understanding the regulatory mechanisms of CCL2 can provide potential targets for the treatment of inflammatory diseases.
CELL PROLIFERATION
(2023)
Review
Environmental Sciences
Dong Li, Yan Yang, Youping Li, Xiaohua Zhu, Zeqin Li
Summary: Environmental exposure can lead to changes in epigenetic regulation, affecting gene expression. Studies have shown that histone modifications, DNA methylation, RNA modifications, and non-coding RNA expression play important roles in this process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Plant Sciences
Xiuming Li, Xuemei Wang, Yi Zhang, Aihong Zhang, Chun-Xiang You
Summary: This review summarizes the various mechanisms involved in regulating fruit ripening, including transcription factors, hormones, and epigenetic modifications. The research progress in tomato and other fleshy fruits is discussed, with a focus on the critical role of epigenetic regulation.
HORTICULTURE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Byung Chul Jung, Sona Kang
Summary: Obesity is strongly associated with insulin resistance, and chronic low-grade tissue inflammation and systemic inflammation are proposed as major mechanisms. Adipose tissue serves as a crucial link between inflammation and metabolism, while epigenetic modifications play a key role in gene regulation in response to environmental changes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Biochemistry & Molecular Biology
Zengde Chi, Yan Lu, Yinlong Yang, Bingqing Li, Peiyuan Lu
Summary: PD-1 serves as a crucial co-inhibitory receptor in regulating T cell immunity and peripheral tolerance. It plays a dual role in preventing T cell overactivation and maintaining T cell exhaustion. Additionally, the PD-1 signaling pathway is exploited by tumor cells to evade immune responses and is essential for maintaining peripheral tolerance and preventing autoimmune diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Yueqi Qiu, Delong Feng, Wenjuan Jiang, Tingting Zhang, Qianjin Lu, Ming Zhao
Summary: Three-dimensional (3D) genomics investigates the relationship between gene regulatory function and the spatial structure of chromatin. It uses technologies like chromosome conformation capture (3C) to study chromatin folding and its impact on gene function. Integration of multi-omics data is crucial for a comprehensive analysis of the relationships between regulatory components and gene function. 3D genome folding plays a role in immune cell differentiation, activation, and dysfunction, and is involved in various diseases including autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Elly I. Lewerissa, Nael Nadif Kasri, Katrin Linda
Summary: Autophagy is a crucial metabolic process for maintaining cellular homeostasis and survival. Recent studies have shown the importance of autophagy in brain function, particularly in neuronal development and functioning. Mutations in autophagy-related genes as well as genes involved in epigenetic regulation have been linked to neurodevelopmental disorders (NDDs). This suggests that aberrant autophagic regulation may contribute to nervous system impairments in NDDs with disturbed epigenetic regulation.
Article
Biochemistry & Molecular Biology
Jilu Wang, Aiai Shi, Jie Lyu
Summary: This study presents a comprehensive list of epigenetic regulator genes based on evolutionary analysis across 23 species. The researchers observe a consistent tissue-specific expression pattern of duplicated genes across different species, and suggest a link between expression specificity, gene evolution, and gene function. The study further suggests that gene duplication can generate tissue-specific genes with the same epigenetic substrates, which may be closely related to their regulatory specificity in tissue development.
Review
Biochemistry & Molecular Biology
David Nunez-Corona, Estefania Contreras-Sanzon, Jonathan Puente-Rivera, Rodrigo Arreola, Minerva Camacho-Nuez, Jose Cruz Santiago, Edgar Antonio Estrella-Parra, Julio Cesar Torres-Romero, Cesar Lopez-Camarillo, Maria Elizbeth Alvarez-Sanchez
Summary: Testicular cancer is the most common tumor in males aged 15 to 35, with a high number of new cases and deaths each year. Non-coding RNAs (ncRNAs) play a crucial role in the regulation of cellular processes and pathologies, including testicular cancer. Epigenetic modifications, such as histone modifications and DNA methylation, along with microRNA (miRNA) regulation, are also associated with testicular tumor progression and treatment response. This review focuses on the latest discoveries in the epigenetic aspect of testicular cancer, particularly the involvement of proteins and ncRNAs like miRNAs and lncRNA, highlighting their relevance in pathogenesis and potential for prognostic evaluation and targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Fen Feng, Peng Jiao, Jinpeng Wang, Yanxia Li, Binwu Bao, Zhuoma Luoreng, Xingping Wang
Summary: This article summarizes the regulatory role of lncRNAs in immune responses and their association with various diseases, providing references for the molecular regulation, genetic diagnosis, and treatment of inflammatory diseases.
Review
Neurosciences
Amy Loughman, Christina J. Adler, Helen Macpherson
Summary: While advancing age is the primary risk factor for Alzheimer's disease, approximately one third of dementia cases can be attributed to modifiable risk factors. Recent research has found a link between oral health, the oral microbiome, and the risk and pathophysiology of Alzheimer's disease. The oral microbiome plays a role in the cerebrovascular and neurodegenerative pathology of Alzheimer's disease through inflammatory, vascular, neurotoxic, and oxidative stress pathways. The oral microbiome may have interactions with certain lifestyle risk factors of dementia. Future clinical studies may identify specific oral microbial targets and optimal oral health practices to reduce the risk of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Jiaping Zhu, Xiaofeng Cao, Xian Deng
Summary: Temperature is a major environmental factor affecting plant growth and development, and plants have developed various mechanisms to sense and adapt to high temperature. Recent research has shown the importance of transcription factors, epigenetic factors, and their coordination in plant temperature responses and phenotypic adaptation. This article summarizes recent advances in understanding the molecular and cellular mechanisms of plant acclimation to high temperature, explores how plant meristems sense and integrate environmental signals, and suggests future directions for studying heterogeneous responses in different cell types to improve plant environmental plasticity.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Aileen Julia Riesle, Meijiang Gao, Marcus Rosenblatt, Jacques Hermes, Helge Hass, Anna Gebhard, Marina Veil, Bjorn Gruening, Jens Timmer, Daria Onichtchouk
Summary: This study investigates the combinatorial mechanisms of genome activation and shows that zebrafish genome activators Pou5f3 and Nanog exhibit different roles in the activation process. They act as pioneer-like transcription factors on synergistic enhancers, promoting histone acetylation and transcription activation. However, on antagonistic enhancers, one of the factors acts as a non-pioneer-like transcription factor, competing with the activator and blocking its effects. This activator-blocker mechanism restricts widespread transcriptional activation and prevents premature expression of late developmental genes in early embryos.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hongyan Sun, Naying Li, Jishuang Tan, Huan Li, Jibin Zhang, Lujiang Qu, Susan J. Lamont
Summary: This study found that overexpression of NFIB accelerates APEC-induced apoptosis and inflammation through up-regulation of RIP2 mediated downstream pathways in chicken HD11 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
