Review
Biochemistry & Molecular Biology
Joanna Tokajuk, Piotr Deptula, Ewelina Piktel, Tamara Daniluk, Sylwia Chmielewska, Tomasz Wollny, Przemyslaw Wolak, Krzysztof Fiedoruk, Robert Bucki
Summary: The mechanisms for maintaining oral cavity homeostasis are influenced by environmental factors, and the oral microbiota and immune molecules play important roles. The LL-37 peptide is involved in maintaining microbial balance and is associated with the development of oral pathologies and systemic diseases.
Review
Engineering, Biomedical
Albert Donald Luong, Alyah Buzid, John H. T. Luong
Summary: Epithelial cells and leukocytes release AMPs as a defense mechanism against oral pathogens. However, the concentrations of AMPs are low and they are unstable under physiological conditions. Efforts have been made to synthesize stable and low-cytotoxicity AMPs and improve their antimicrobial activity using nanomaterials and biomolecules. Future research should focus on developing AMPs that promote remineralization and antibacterial adhesion. Nanostructured AMPs are a promising alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis and modification.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Davide Mancino, Naji Kharouf, Francesco Scavello, Sophie Helle, Fouad Salloum-Yared, Angela Mutschler, Eric Mathieu, Philippe Lavalle, Marie-Helene Metz-Boutigue, Youssef Haikel
Summary: Resistance to antifungal therapy is increasing, and host-defense peptides are emerging as promising candidates. This study assessed the effectiveness of Catestatin-derived peptides against Candida species and the synergistic effect with serum albumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ariuntsetseg Khurelchuluun, Osamu Uehara, Durga Paudel, Tetsuro Morikawa, Yutaka Kawano, Mashu Sakata, Hiroshi Shibata, Koki Yoshida, Jun Sato, Hiroko Miura, Hiroki Nagayasu, Yoshihiro Abiko
Summary: The study revealed that a bee pollen diet can have beneficial effects on oral and systemic health by modulating the oral microbiome and antimicrobial peptides. Significant changes were observed in the oral bacterial population and mRNA levels of antimicrobial peptides in the bee pollen group compared to the control group. Further research is needed to clarify the impact of a bee pollen diet on overall human health.
Review
Dentistry, Oral Surgery & Medicine
John Yun Niu, Iris Xiaoxue Yin, May Lei Mei, William Ka Kei Wu, Quan-Li Li, Chun Hung Chu
Summary: Antimicrobial peptides are naturally occurring protein molecules with antibacterial activity. They play important roles in oral health and diseases by killing pathogenic microorganisms, promoting tissue healing, and serving as biomarkers.
MOLECULAR ORAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gergo Kallo, Petra Magdolna Bertalan, Ildiko Marton, Csongor Kiss, Eva Csosz
Summary: Oral squamous cell carcinoma (OSCC) is associated with microbial infections and/or dysbiosis. OSCC can alter the protein composition of saliva, affecting the chemical barrier function of the oral cavity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Immunology
Sergio Gonzalez-Acosta, Victoria Baca-Gonzalez, Patricia Asensio-Calavia, Andrea Otazo-Perez, Manuel R. Lopez, Antonio Morales-delaNuez, Jose Manuel Perez de la Lastra
Summary: Microbial resistance is a growing global health problem, and advancements in insect antimicrobial peptides (AMPs) provide a new approach to combat this issue. This study explores a priming method for mealworms that simulates natural infection via oral administration. The results show that oral priming with inactivated microorganisms can enhance the survival rate of mealworm larvae and induce antimicrobial activity in their hemolymph.
Article
Materials Science, Biomaterials
Haijun Fu, Jiayu Yang, Zongshan Shen, Yong Zhang, Shuhong Kuang, Lifeng Li, Zhengmei Lin, Xuetao Shi
Summary: Antimicrobial peptides (AMPs)-modified polycaprolactone (PCL)-collagen nanosheets (APCNs) were developed to enhance the adhesion of drug-loaded patches in the oral cavity. The APCNs exhibited strong and continuous adhesion to irregular buccal mucosa surfaces and showed high antibacterial activity against different types of bacteria. They also demonstrated good biocompatibility and promoted ulcer healing in a rat model.
BIOMATERIALS SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Wayne Tsang, Annika Linde, Janina A. Krumbeck, Guangxi Wu, Young J. Kim, Gerald H. Lushington, Tonatiuh Melgarejo
Summary: Oral disease in cats is a significant concern in small animal practice, with antimicrobial resistance genes being found commonly in the mouth of cats, potentially transferring to humans and making certain antibiotics less effective. Feline chronic gingivostomatitis is a severe immune-mediated inflammatory disease where antimicrobial-resistant bacteria and fungi coexist, highlighting the need for concern in both feline and human medicine.
Review
Immunology
Yuying Jiang, Chuqiang Yin, Jianning Mo, Xiaoyu Wang, Ting Wang, Guotai Li, Qihui Zhou
Summary: The recent advances in carbon dots (CDs) against diverse oral pathogens and their potential in the treatment of oral microbial infections are discussed in this review. The antimicrobial abilities of CDs against oral planktonic bacteria, intracellular bacteria, oral pathogenic biofilms, and fungi are highlighted. The prospects of CDs in early diagnosis of oral infection and pathogen microbiological examination are also proposed. The current limitations of CDs in the treatment of oral microbial infections are discussed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Infectious Diseases
Waqas Ali, Ahmad Elsahn, Darren S. J. Ting, Harminder S. Dua, Imran Mohammed
Summary: One of the major challenges in the medical community today is the increasing antimicrobial resistance (AMR) coupled with the reduction in available antimicrobial treatments. The overuse of antibiotics has led to a significant rise in AMR, with estimates suggesting over 10 million lives could be lost by 2050. Host Defence Peptides (HDPs) have shown promise as an alternative to traditional antibiotics, demonstrating efficacy against currently resistant microbial variants. In light of the global COVID-19 pandemic, the potential use of HDPs as a therapeutic option and preventive measure against the spread of the SARS-CoV-2 variant has been examined.
Article
Food Science & Technology
Jose J. L. Silva, Maria R. A. de Miranda, Pedro F. N. Souza
Summary: Fungal contamination is a major cause of food spoilage, posing serious risks to human health and economic losses. This review discusses the recent advances in using synthetic peptides as agents to address foodborne fungal resistance and their applications in food preservation.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Michal Otreba, Lukasz Marek, Natalia Tyczynska, Jerzy Stojko, Anna Kurek-Gorecka, Michal Gorecki, Pawel Olczyk, Anna Rzepecka-Stojko
Summary: Periodontal diseases and oral cavity diseases are common chronic inflammatory diseases worldwide. Propolis has been shown to exhibit antimicrobial activity against bacteria responsible for these diseases. Further research is needed before propolis can be widely used.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Natalia Surin Hudakova, Jana Kacirova, Miriam Sondorova, Svetlana Selianova, Rastislav Mucha, Marian Mad'ar
Summary: Bacillus licheniformis is a widely used bacterium in human and veterinary health, known for producing bioactive substances with antimicrobial and antibiofilm effects. This study evaluated the inhibitory effect of B. licheniformis strains from canine dental biofilm on pathogenic oral bacteria. The cell-free supernatants of B. licheniformis showed significant antimicrobial activity against specific oral bacteria, and the antimicrobial effect was not affected by enzyme treatment. Further research is needed to identify the antimicrobial substances.
