Article
Oncology
Xinyue Qin, Yinhao Chen, Shuo Ma, Lei Shen, Shaoqing Ju
Summary: TM4SF18 is a promising biomarker for gastric cancer, promoting proliferation, migration, and invasion abilities of GC cells, and being associated with immune response.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Chia-Lang Fang, Yu-Feng Tian, Shiau-Shiuan Lin, Shih-Ting Hung, You-Cheng Hseu, Chun-Chao Chang, Chia-Lin Chou, Li-Chin Chen, Wen-Ching Wang, Kai-Yuan Lin, Ding-Ping Sun
Summary: Gastric cancer is the 4th most common and 3rd deadliest cancer worldwide. This study investigated the relationship between GRK3 and gastric cancer prognosis and explored the role of GRK3 in gastric cancer development. The researchers found that GRK3 overexpression was significantly associated with metastasis, TNM stage, and vascular invasion. High GRK3 expression was also linked to shorter disease-free survival and overall survival in patients. Knocking down GRK3 in gastric cancer cells inhibited cell proliferation, migration, and invasion. The findings suggest that GRK3 could potentially serve as a biomarker for gastric cancer prognosis and a target for therapy.
Article
Immunology
Jing Yang, Hui Wei, Mengxiao Liu, Taobi Huang, Xidong Fang, Xiangqing Ren, Hao Yuan, Ya Zheng, Yuping Wang, Yongning Zhou
Summary: This study found that high expression of HAMP is associated with poor prognosis in gastric cancer, and HAMP affects the survival rate of patients with gastric cancer through immune cell infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Shuo Ma, Shan Kong, Xinliang Gu, Yanhua Xu, Mei Tao, Lei Shen, Xianjuan Shen, Shaoqing Ju
Summary: CircPTPN22 is upregulated in gastric cancer tissues, cells, and plasma, and positively correlated with metastasis. It can serve as a diagnostic marker and predict patient prognosis. CircPTPN22 inhibits cell proliferation and metastasis through competitive binding of miRNAs to regulate the EMT pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jun-Yan Liu, Jing Yao, Jia-Jia Liu, Tao He, Fang-Jie Wang, Tian-Yu Xie, Jian-Xin Cui, Xiao-Dong Yang
Summary: In this study, a novel survival-related ferroptosis-related lncRNA (FRlncRNA), LASTR, was identified in gastric cancer (GC). High expression of LASTR was associated with shorter overall survival and progression-free survival of GC patients. Knocking down LASTR had a significant effect on reducing the proliferation of GC cells. Additionally, the expression of LASTR was negatively associated with certain immune cells. These findings suggest that LASTR may serve as a novel prognostic biomarker for predicting response to cancer immunotherapy and therapeutic target for GC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Shaohua Huang, Liping Ma, Biyang Lan, Ning Liu, Wenwei Nong, Zhihu Huang
Summary: Through bioinformatic analyses, key dysregulated genes associated with the development of gastric cancer were identified, showing potential prognostic value. High expression of LRFN4 and LOC100506388 was linked to a higher risk of gastric cancer, while tumor infiltration levels were associated with overall survival in patients.
Article
Oncology
Secil Demirkol Canli, Meral Uner, Baris Kucukkaraduman, Diren Arda Karaoglu, Aynur Isik, Nesrin Turhan, Aytekin Akyol, Ismail Gomceli, Ali Osmay Gure
Summary: By analyzing the transcriptomic data from primary gastric tumors, a novel list of 20 prognostic genes was identified, and gastric tumors were classified into two subgroups based on stromal gene expression (Stromal-UP and Stromal-DOWN). The Stromal-UP subgroup showed a more mesenchymal profile and a poor prognosis. It was also found that a higher stromal content in FFPE tissues was associated with shorter overall survival.
Article
Biotechnology & Applied Microbiology
Diqun Chen, Rouxin Zhang, Aosi Xie, Jinpeng Yuan, Jinhai Zhang, Yongjian Huang, Hongxia Zhang, Feiran Zhang
Summary: Gastric cancer is among the most common and deadly cancers globally. This study reveals that NUDT10 expression is significantly reduced in GC tissues compared to normal tissues, and high expression is associated with worse prognosis in terms of tumor malignancy and survival outcomes. NUDT10 shows potential as an independent biomarker for GC prognosis.
Article
Oncology
Zhengxin Wu, Jinshui Tan, Yifan Zhuang, Mengya Zhong, Yubo Xiong, Jingsong Ma, Yan Yang, Zhi Gao, Jiabao Zhao, Zhijian Ye, Huiwen Zhou, Yuekun Zhu, Haijie Lu, Xuehui Hong
Summary: The study revealed dysregulation of pyrimidine metabolism in GC and established a prognostic model based on differentially expressed genes in pyrimidine metabolism, confirming the reliability and independence of the model. Additionally, nomograms were created to visually depict the survival rate of GC patients according to important clinical factors, including the risk model.
CANCER CELL INTERNATIONAL
(2021)
Article
Genetics & Heredity
XiongHui Rao, JianLong Jiang, ZhiHao Liang, JianBao Zhang, ZheHong Zhuang, HuaiYu Qiu, Huixing Luo, Nuoqing Weng, Xiaobin Wu
Summary: Down-regulated CLDN10 in gastric cancer is associated with better overall survival and may serve as a potential prognostic biomarker, correlating to immune infiltration levels in gastric cancer.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Yan Hu, Jingjing Li, Haifeng Luo, Wenli Song, Jiyuan Yang
Summary: The study identified COL1A1, COL1A2, COL6A3, and SULF1 as significantly upregulated genes in stomach adenocarcinomas through ONCOMINE analysis, with a strong correlation between their expression and TNM stage. Low transcriptional levels of these genes were associated with longer overall survival in gastric cancer patients according to Kaplan-Meier analysis. Additionally, there was a close relationship between the expression of these genes and immune cell infiltration, indicating their potential as prognostic biomarkers and indicators of immune status in gastric cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shuo Ma, Yuming Yao, Yanhua Xu, Mingyuan Zou, Meiling Zhou, Gulinaizhaer Abudushalamu, Yaya Chen, Shijie Cai, Chen Zhang, Guoqiu Wu
Summary: The expression level of circHAS2 in gastric cancer patients is correlated with clinical pathological parameters and can be used as an effective diagnostic and prognostic marker.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Biao Fan, Ke Ji, Zhaode Bu, Ji Zhang, Heli Yang, Jialin Li, Xiaojiang Wu
Summary: The study found that ARHGAP11A is elevated in various cancers, including gastric cancer. In gastric cancer, high expression of ARHGAP11A is significantly correlated with better prognosis. The expression of ARHGAP11A is negatively associated with infiltration levels of CD8(+) T cells, CD4(+) T cells, macrophages and dendritic cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemical Research Methods
Yuan Gu, Ying Gao, Xiaodan Tang, Huizhong Xia, Kunhe Shi
Summary: The study found that CPZ is overexpressed in multiple types of cancer, including gastric cancer, and its overexpression is significantly associated with poor prognosis in STAD. CPZ expression levels are correlated with immune infiltration and diverse immune marker sets in STAD, indicating its potential role as a biomarker for GC.
CURRENT BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Wenfang Zhao, Jiahui Lin, Sha Cheng, Huan Li, Yufeng Shu, Canxia Xu
Summary: This study found that COMMD10 was highly expressed in gastric adenocarcinoma (STAD) and was associated with poor prognosis. Additionally, COMMD10 was related to m6A modification and immune infiltration in STAD.
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.
