期刊
PEPTIDES
卷 48, 期 -, 页码 134-136出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2013.08.005
关键词
Apelin; Cholecystokinin; Glucagon-like peptide 1; STC-1 cells; Rat
资金
- French Ministry of Higher Education and Research
Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1. (C) 2013 Elsevier Inc. All rights reserved.
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