Article
Medicine, General & Internal
Lukasz Wolowiec, Joanna Banach, Jacek Budzynski, Anna Wolowiec, Mariusz Kozakiewicz, Maciej Bielinski, Albert Jasniak, Agata Olejarczyk, Grzegorz Grzesk
Summary: The study aimed to assess the prognostic value of plasma catestatin concentration in patients with heart failure with reduced ejection fraction (HFrEF) in predicting unplanned hospitalization and all-cause death at a 2-year follow-up. The study included 122 hospitalized Caucasian patients in NYHA classes II to IV. Patients who died during the follow-up period had higher levels of CST, NT-proBNP, troponin T, creatinine, and glucose, and lower TAPSE, hemoglobin concentration, hematocrit, and platelet count compared to survivors. Plasma catestatin concentration was positively associated with NYHA class and blood NT-proBNP concentration. Higher plasma catestatin concentration increased the risk of all-cause death by more than five times. Plasma CST concentration is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in patients with HFrEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Josko Bozic, Marko Kumric, Tina Ticinovic Kurir, Hrvoje Urlic, Dinko Martinovic, Marino Vilovic, Nada Tomasovic Mrcela, Josip A. Borovac
Summary: Cardiovascular diseases account for a significant portion of global mortality, with traditional mechanistic explanations being questioned and the dysregulation of the sympathetic nervous system emerging as a key player in their pathophysiology.
Review
Cardiac & Cardiovascular Systems
Ewa Zalewska, Piotr Kmiec, Krzysztof Sworczak
Summary: Catestatin is a multifunctional peptide that regulates the cardiovascular and immune systems as well as metabolic homeostasis. It has been shown to reduce adipose tissue, inhibit inflammatory response, and prevent atherosclerosis. Clinical studies indicate that catestatin may influence the development of hypertension and cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zeping Qiu, Yingze Fan, Zhiyan Wang, Fanyi Huang, Zhuojin Li, Zhihong Sun, Sha Hua, Wei Jin, Yanjia Chen
Summary: This study found that catestatin has a protective effect on cardiac function in HFpEF by inhibiting reactive oxygen species generation from mitochondrial electron transport chain. The serum concentration of catestatin is elevated in patients with HFpEF, probably as a relatively insufficient but self-compensatory mechanism.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Magdalena Dudek, Marta Kaluzna-Oleksy, Jacek Migaj, Filip Sawczak, Helena Krysztofiak, Maciej Lesiak, Ewa Straburzynska-Migaj
Summary: New parameters and markers, such as the ST2 protein, are being explored to better assess patients with heart failure. This protein is involved in cardioprotection and provides information on myocardial remodeling and fibrosis. A study on hospitalized patients with heart failure with reduced ejection fraction found that higher levels of sST2 were associated with increased risk of all-cause deaths. sST2 could serve as an independent risk factor for mortality in HFrEF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Chenlong Jiang, Xiangde Lai, Feng Han, Zhijun Gao, Haixia Yang, Xuan Zhao, Huajie Pang, Bin Qiao, Hua Pei, Qiang Wu
Summary: Heart failure (HF) is a major public health problem caused by heart circulation disorders. Early detection and diagnosis are important for HF prevention and treatment, so it is necessary to establish a simple and sensitive method to monitor the diagnostic biomarkers of HF. In this study, a visual detection method using gold nanorods (AuNRs) and double-antibody-sandwich ELISA was developed for the detection of NT-proBNP, which is a sensitive biomarker for HF. The method showed a wide concentration range and low detection limit, with negligible cross-reactivity and high sample recovery rates.
Article
Medicine, Research & Experimental
Lu Qian, Qian Zhao, Ping Yu, Jinhui Lu, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng, Zuoren Yu
Summary: Heart failure is a leading cause of death worldwide, and its incidence is increasing due to the aging population. In this study, circulating miRNAs were analyzed to identify diagnostic biomarkers for heart failure. Two miRNAs, miR-30a-5p and miR-654-5p, were found to be significantly changed in the plasma of heart failure patients. A two-circulating miRNA model was developed for diagnosis and prognosis of heart failure, which showed promising potential in an independent validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Clemens Wittenbecher, Fabian Eichelmann, Estefania Toledo, Marta Guasch-Ferre, Miguel Ruiz-Canela, Jun Li, Fernando Aros, Chih-Hao Lee, Liming Liang, Jordi Salas-Salvado, Clary B. Clish, Matthias B. Schulze, Miguel Angel Martinez-Gonzalez, Frank B. Hu
Summary: This study identified and validated two lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF risk. Lipid profiling may capture preclinical molecular alterations that predispose to incident HF.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Walter J. Paulus, Michael R. Zile
Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Dongyu Wang, Emily S. Lau, Juhi K. Parekh, Norrina Allen, Bruce M. Psaty, Emelia J. Benjamin, Daniel Levy, Thomas J. Wang, Sanjiv J. Shah, John S. Gottdiener, James L. Januzzi, Jennifer E. Ho
Summary: This study compares the prevalence and prognosis of heart failure (HF) stages according to the 2013 and 2022 ACC/AHA/HFSA definitions. The new standards result in a substantial shift of individuals from stage A to stage B, and those in stage B have a higher risk of progression to symptomatic HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizua, Daishi Nakagawa, Kimi Sato, Tomoko Machino-Ohtsuka, Isao Nishi, Yoshie Hamada-Harimura, Seika Sai, Akinori Sugano, Masako Baba, Haruhiko Higuchi, Kazutaka Aonuma, Nobuyuki Ohte, Masaki Ieda
Summary: This study showed that sST2 can predict cardiovascular events in patients with heart failure, especially in those with preserved ejection fraction. Other biomarkers such as PTX3, Gal-3, and high-sensitivity troponin T did not demonstrate significant predictive value after adjustment for clinical variables.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Job A. J. Verdonschot, Joao Pedro Ferreira, Pierpaolo Pellicori, Hans-Peter Brunner-La Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Nicolas Girerd, Beatrice Mariottoni, Johannes Petutschnigg, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Stephane R. B. Heymans
Summary: Among patients at risk for heart failure, diabetic individuals have higher levels of proteins related to inflammation and proteolysis in their plasma compared to non-diabetic patients. Treatment with spironolactone has similar effects on protein biomarkers in diabetic and non-diabetic patients, producing anti-fibrotic, anti-remodelling, blood pressure, and natriuretic peptide lowering effects regardless of diabetes status.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Health Care Sciences & Services
Agata Zdanowicz, Szymon Urban, Barbara Ponikowska, Gracjan Iwanek, Robert Zymlinski, Piotr Ponikowski, Jan Biegus
Summary: Heart failure is a major public health issue and early diagnosis and risk stratification tools are crucial. Congestion and renal dysfunction are markers of heart failure, impacting cardiovascular homeostasis. Early detection of congestion and assessment of renal function are important for tailored therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Suriya Prausmueller, Georg Spinka, Henrike Arfsten, Stefanie Stasek, Rene Rettl, Philipp Emanuel Bartko, Georg Goliasch, Guido Strunk, Julia Riebandt, Julia Mascherbauer, Diana Bonderman, Christian Hengstenberg, Martin Huelsmann, Noemi Pavo
Summary: This study aimed to investigate the relationship between neutrophil transmembrane neprilysin (mNEP) and disease severity, adverse remodeling, and outcome in HFrEF patients. The findings suggest that lower neutrophil mNEP was associated with increasing disease severity and adverse remodeling markers, while higher neutrophil mNEP was associated with reduced risk for mortality and cardiovascular hospitalizations. The results highlight the potential significance of neutrophil mNEP in predicting outcomes in HFrEF patients.
Article
Cardiac & Cardiovascular Systems
Sarina Schaefer, Muhammet Ali Aydin, Sebastian Appelbaum, Kari Kuulasmaa, Tarja Palosaari, Francisco Ojeda, Stefan Blankenberg, Pekka Jousilahti, Veikko Salomaa, Mahir Karakas
Summary: The study found a strong association between low testosterone levels and future heart failure in men, but this association became non-significant after full adjustment. In contrast, testosterone levels were not significantly associated with incident heart failure in women.
Article
Cardiac & Cardiovascular Systems
Song-Yun Chu, Jie Jiang, Yu-Ling Wang, Qin-Hui Sheng, Jing Zhou, Yan-Sheng Ding
Article
Biochemistry & Molecular Biology
Song-Yun Chu, Fen Peng, Jie Wang, Lin Liu, Lei Meng, Jing Zhao, Xiao-Ning Han, Wen-Hui Ding
Article
Cardiac & Cardiovascular Systems
Song-Yun Chu, Qin-Hui Sheng, Er-Dong Chen, Han Jin, Jie Jiang, Yu-Ling Wang, Peng-Kang He, Jing Zhou, Yan-Sheng Ding
Summary: In patients requiring a high percentage of ventricular pacing, His-bundle pacing may be an alternative to biventricular pacing, with LBB pacing offering lower threshold and maintaining synchrony. For patients with high-grade atrioventricular block and RBBB, LBB pacing could be a safe and effective procedure.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Song-Yun Chu, Pei-Wen Li, Xiao-Ning Han, Lin Liu, Xiao-Jin Ye, Jie Wang, Jing Zhao, Wen-Hui Ding
Summary: Advanced age is associated with increased perioperative cardiac risk, but this association differs by sex. Tailored strategies should be considered with respect to the patient's sex.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Li-Bin Shi, Yu-Chuan Wang, Song-Yun Chu, Alessandro De Bortoli, Peter Schuster, Eivind Solheim, Jian Chen
Summary: This study demonstrates that a contact force of at least 5 g is necessary for adequate ablation. With a certain level of contact force, increasing power output or prolonging ablation time can enhance lesion formation. Impedance drop is positively correlated with CF level at different power outputs. HPSD ablation with 50 W for 10 s is equivalent to conventional ablation with 25 W for 40 s or 30-35 W for 20-30 s in terms of lesion formation.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Songyun Chu, Pengfei Sun, Yan Zhang, Jianping Li, Lin Liu, Ying Shi, Haibo Wang, Hu Chen, Michael Fu, Yong Huo
Summary: In a nationwide registry of cardiogenic shock patients in China, the use of IABP did not show improved survival but increased healthcare consumption. However, IABP appears to be protective in patients with myocarditis or those who did not receive early PCI treatment.
Article
Cardiac & Cardiovascular Systems
Song-Yun Chu, Jie Jiang, Yu-Ling Wang, Qin-Hui Sheng, Jing Zhou, Yan-Sheng Ding
Summary: Atrial fibrillation detected by pacemakers is common and higher AF burden predicts more adverse cardiac outcomes, suggesting the need for rhythm control intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Songyun Chu
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Songyun Chu, Pengkang He, Jing Zhou, Yuling Wang, Ying Yang
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Bei-Ning Wang, Yu-Xi Li, Wei Ma, Song-Yun Chu, Zhi-Hao Liu, Wen-Hui Ding, Jian-Ping Li
JOURNAL OF GERIATRIC CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Songyun Chu, Han Jin, Erdong Chen, Qinhui Sheng, Ying Yang, Jianxing Qiu, Jing Zhou, Jie Jiang, Yansheng Ding
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jinglin Gu, Yuxi Li, Lan Gao, Pengkang He, Dan Liu, Changsong Qi, Jifang Gong, Xi Cao, Wei Ma, He Wang, Songyun Chu, Yueyuan Li, Wenhui Ding, Lin Shen, Jianping Li
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Songyun Chu, Eivind Solheim, Jian Chen, Per Ivar Hoff, Peter Schuster
JOURNAL OF ARRHYTHMIA
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Y. Songyun Chu, Q. H. Sheng, J. Jiang, J. Zhou, Y. S. Ding
EUROPEAN JOURNAL OF HEART FAILURE
(2018)
Article
Oncology
Jing Zhao, Hui-Ping Gu, Jie Jiang, Jie-Wang, Lin-Liu, Xiao-Ning Han, Song-Yun Chu, Lin Xue, Wen-Hui Ding
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.