期刊
PEPTIDES
卷 42, 期 -, 页码 70-77出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2012.12.022
关键词
ACTH; Anxiety; Autonomic nervous system; Catecholamines; CRF; Food intake; Gastrointestinal motility; Octreotide; ODT8-SST; Stress
资金
- German Research Foundation [STE 1765/3-1]
- Charite university [89441 176]
- Sonnenfeld foundation
- VA Research Career Scientist Award
- VA Merit Award
- NIH R01 [DK 33061, DK57238]
Somatostatin-14 was discovered in 1973 in the hypothalamus as a peptide inhibiting growth hormone release. Somatostatin interacts with five receptor subtypes (sst(1-5)) which are widely distributed in the brain with a distinct, but overlapping, expression pattern. During the last few years, the development of highly selective peptide agonists and antagonists provided new insight to characterize the role of somatostatin receptor subtypes in the pleiotropic actions of somatostatin. Recent evidence in rodents indicates that the activation of selective somatostatin receptor subtypes in the brain blunts stress-corticotropin-releasing factor (CRF) related ACTH release (sst(2/5)), sympathetic-adrenal activaton (sst(5)), stimulation of colonic motility (sst(1)), delayed gastric emptying (sst(5)), suppression of food intake (sst(2)) and the anxiogenic-like (sst(2)) response. These findings suggest that brain somatostatin signaling pathways may play an important role in dampening CRF-mediated endocrine, sympathetic, behavioral and visceral responses to stress. Published by Elsevier Inc.
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